ABSTRACT
Adenovirus infections are a frequent cause of severe complications in the post allogeneic bone marrow transplantation period, and to date, no established form of treatment exists. We report the case of an autologous bone marrow transplant recipient who developed adenovirus pneumonitis which was successfully treated with intravenous ribavirin.
Subject(s)
Adenoviridae Infections/drug therapy , Antiviral Agents/administration & dosage , Bone Marrow Transplantation/adverse effects , Leukemia, Myeloid/therapy , Pneumonia, Viral/drug therapy , Ribavirin/administration & dosage , Acute Disease , Adenoviridae Infections/etiology , Adult , Humans , Injections, Intravenous , Male , Pneumonia, Viral/etiology , Transplantation, HomologousABSTRACT
We have identified silent amino acid substitutions in two alpha chain variants present in families from Iowa, USA, and Granada, Spain. Both involve an alanine residue in the core peptide, namely Ala-->Val at position 111 (codon change in the alpha 2 gene; GCC->GTC; Hb Anamosa) and Ala-->Ser at position 123 (codon change in the alpha 1 gene; GCC-->TCC; Hb Mulhacen). The two variants are stable. Sequencing of the amplified alpha 2- and alpha 1-globin genes greatly facilitated the characterization of the two variants.