ABSTRACT
AIM: The purpose of the study was to analyze the potential capacity of a dietary supplement, based on gamma linolenic acid, vitamin E, vitamin C, beta-carotene, coenzyme Q10 and Vitis Vitifera, to reduce side effects, in particular the dry skin, erythema and desquamation, due to treatment with oral isotretinoin, and evaluate the ability of the product to increase adherence to therapy in patients with acne. METHODS: Forty-eight patients with nodular acne (32 females and 16 males) were randomly divided into 2 groups: 24 received isotretinoin therapy (20-30 mg/day) for 6 months associated to dietary supplement (twice a day), while the other 24 patients received only isotretinoin (20-30 mg/day) for 6 months. For all patients the degree of acne severity, through GAGS (Global Acne Grading System), the sebum production by Sebutape, the hydration by Corneometer and the erythema by Mexameter, were measured. We have also evaluated the adherence to treatment, asking to patients how many days a week they follow the therapy. RESULTS: Patients treated with dietary supplement had lower side effects, with a less degree of erythema and dryness, and greater degree of hydration; a greater adherence to therapy was also reported. CONCLUSION: Thanks to antioxidant and moisturizing properties, the dietary supplement containing gamma linolenic acid, vitamin E, vitamin C, betacarotene, coenzyme Q10 and Vitis Vitifera, can be considered a useful supplement in the treatment and prevention of dry skin associated with the use of oral isotretinoin.
Subject(s)
Acne Vulgaris/drug therapy , Dermatologic Agents/administration & dosage , Dermatologic Agents/adverse effects , Dietary Supplements , Erythema/prevention & control , Isotretinoin/administration & dosage , Isotretinoin/adverse effects , Skin/drug effects , Acne Vulgaris/diagnosis , Administration, Oral , Adolescent , Adult , Ascorbic Acid/therapeutic use , Dose-Response Relationship, Drug , Erythema/chemically induced , Female , Humans , Italy , Male , Severity of Illness Index , Treatment Outcome , Ubiquinone/analogs & derivatives , Ubiquinone/therapeutic use , Vitamin E/therapeutic use , Vitamins/therapeutic use , Vitis , beta Carotene/therapeutic use , gamma-Linolenic Acid/therapeutic useABSTRACT
The generalized form of lichen nitidus (LN) with oral and nail changes is extremely rare in childhood. We report a 10-year-old boy with generalized LN associated with oral involvement and onychodystrophy. Oral lesions showed yellowish papules on the gums. The nails had longitudinal striations and pits on the finger-nails, and transversal ridging of the big toes was found. Cutaneous and mucosal lesions as well as onychodystrophy spontaneously cleared within 8 months.
Subject(s)
Lichen Nitidus/complications , Nail Diseases/complications , Stomatitis/complications , Child , Diagnosis, Differential , Humans , Lichen Nitidus/diagnosis , Lichen Nitidus/pathology , Male , Mouth Mucosa/pathology , Nail Diseases/diagnosis , Nail Diseases/pathology , Remission, Spontaneous , Stomatitis/diagnosis , Stomatitis/pathologySubject(s)
Fingers , Hand Dermatoses/pathology , Adult , Female , Humans , Keratosis/pathology , Skin/pathologySubject(s)
Onychomycosis/epidemiology , Adolescent , Adult , Aged , Female , Humans , Italy , Male , Middle Aged , Onychomycosis/microbiologyABSTRACT
A patient with lichen planopilaris with peculiar leukonychia is described. The histologic findings from examination of the nail biopsy specimen are discussed.
Subject(s)
Lichen Planus/complications , Nail Diseases/complications , Humans , Lichen Planus/pathology , Male , Middle Aged , Nail Diseases/pathologySubject(s)
Alopecia Areata/complications , Thyroiditis, Autoimmune/complications , Adolescent , Adult , Age Factors , Alopecia/complications , Child , Child, Preschool , Female , Humans , Male , Middle Aged , Sex FactorsABSTRACT
An unusual case of nail involvement in dermatomyositis in which complete loss of several toenails was the only cutaneous sign of the disease is reported for its clinical interest.
Subject(s)
Dermatomyositis/complications , Nail Diseases/etiology , Dermatomyositis/pathology , Female , Humans , Middle Aged , Nail Diseases/pathology , ToesSubject(s)
Basal Cell Nevus Syndrome/genetics , Carcinoma, Basal Cell/genetics , Skin Neoplasms/genetics , Adult , Female , Humans , Male , Middle AgedSubject(s)
Lichen Planus/pathology , Nail Diseases/pathology , Nails/pathology , Biopsy , Female , Humans , Middle AgedSubject(s)
Ichthyosis/pathology , Adolescent , Biopsy , Cromolyn Sodium/therapeutic use , Female , Humans , Ichthyosis/drug therapy , Skin/pathologySubject(s)
Drug Eruptions/etiology , Phenyl Ethers/adverse effects , Triclosan/adverse effects , Adolescent , Adult , Female , Humans , Male , Patch Tests , Triclosan/therapeutic useABSTRACT
We report the results of a controlled trial on 119 patients affected by patchy alopecia areata involving less than 40% of the scalp. The statistical analysis showed no differences between the results obtained using squaric acid dibutylester, diphencyprone, minoxidil, and placebo in the treatment of this form of alopecia.
Subject(s)
Alopecia Areata/drug therapy , Adolescent , Adult , Age Factors , Aged , Child , Child, Preschool , Clinical Trials as Topic , Cyclobutanes/therapeutic use , Cyclopropanes/therapeutic use , Female , Humans , Male , Middle Aged , Minoxidil/therapeutic use , PlacebosABSTRACT
Electroretinography (ERG) and electro-oculography (EOG) were performed in 98 patients affected by alopecia areata (AA) free from ophthalmologic disorders, and in 40 healthy subjects, in order to evaluate whether or not the retinal pigment epithelium of AA patients shows bioelectrical changes. ERG was normal. EOG, on the contrary, showed a significantly depressed mean value in the AA patient group. Furthermore, depressed EOG occurred more frequently in patients affected by alopecia totalis or universalis as compared with multiple patchy alopecia. These findings prompt the authors to believe that the melanocytes may play a prominent part in the pathogenesis of AA.
