1.
Br J Cancer
; 124(8): 1341-1343, 2021 04.
Article
in English
| MEDLINE
| ID: mdl-33623077
ABSTRACT
Cannabis and its derivatives are being used increasingly by patients with cancer, including patients with glioblastoma multiforme (GBM), the most common and aggressive primary brain malignancy. Despite promising preclinical data suggesting potential anti-cancer effects for cannabinoids in GBM, clinical and safety data are lacking. This editorial will discuss a recent Phase 1b trial of nabiximols oromucosal spray in combination with dose-intense temozolomide in patients with recurrent GBM in the context of other relevant findings in this field.
Subject(s)
Brain Neoplasms/drug therapy , Cannabidiol/administration & dosage , Dronabinol/administration & dosage , Glioblastoma/drug therapy , Temozolomide/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/pharmacology , Cannabidiol/pharmacology , Cell Proliferation/drug effects , Cell Survival/drug effects , Clinical Trials, Phase I as Topic , Dronabinol/pharmacology , Drug Combinations , Humans , Oral Sprays , Temozolomide/pharmacology , Treatment Outcome
2.
JCO Precis Oncol
; 5: 1579-1583, 2021 11.
Article
in English
| MEDLINE
| ID: mdl-34994644
Subject(s)
Carcinoma, Adenoid Cystic/drug therapy , Gamma Secretase Inhibitors and Modulators/therapeutic use , Tetrahydronaphthalenes/therapeutic use , Tracheal Neoplasms/drug therapy , Valine/analogs & derivatives , Carcinoma, Adenoid Cystic/genetics , Humans , Male , Middle Aged , Receptor, Notch1/genetics , Tracheal Neoplasms/genetics , Treatment Outcome , Valine/therapeutic use
3.
Lancet Oncol
; 21(5): 624-627, 2020 05.
Article
in English
| MEDLINE
| ID: mdl-32277907
4.
Nat Cancer
; 1(6): 568-572, 2020 06.
Article
in English
| MEDLINE
| ID: mdl-35121973