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A temperature-sensitive liposomal 1H CEST and 19F contrast agent for MR image-guided drug delivery.
Langereis, Sander; Keupp, Jochen; van Velthoven, Juliën L J; de Roos, Inge H C; Burdinski, Dirk; Pikkemaat, Jeroen A; Grüll, Holger.
J Am Chem Soc ; 131(4): 1380-1, 2009 Feb 04.
Article in English | MEDLINE | ID: mdl-19173663

ABSTRACT

A novel temperature-sensitive liposomal MRI contrast agent has been developed, which allows drug carrier localization using (1)H CEST with simultaneous quantification of the drug release using (19)F MR imaging in response to a local temperature increase.


Subject(s)
Contrast Media/analysis , Contrast Media/chemistry , Fluorine/chemistry , Liposomes/chemistry , Magnetic Resonance Imaging/methods , Temperature , Drug Delivery Systems , Protons , Sensitivity and Specificity , Spectrophotometry
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