1.
Mech Dev
; 95(1-2): 313-6, 2000 Jul.
Article
in English
| MEDLINE
| ID: mdl-10906485
ABSTRACT
The gene KIR4.2 (K(+) inwardly rectifying channel 4.2) has been recently identified in the Down syndrome Chromosome Region 1. We have cloned the mouse ortholog of KIR4.2 and characterized its expression pattern. In situ hybridization showed a restricted and developmentally regulated pattern of expression. The expression is starting at E12.5 and expands at E14.5 in different tissues and organs, which may be affected in Down syndrome: heart, thymus, thyroid gland, and perichondrium. At E17.5, additional epithelia (kidney, bladder, stomach, lung) expressed also strongly the gene.
Subject(s)
Embryonic and Fetal Development/genetics , Gene Expression Regulation, Developmental , Potassium Channels/genetics , Animals , Mice
2.
Transplant Proc
; 26(3): 1424-5, 1994 Jun.
Article
in English
| MEDLINE
| ID: mdl-8029967