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Bioorg Med Chem Lett
; 12(11): 1533-5, 2002 Jun 03.
Article
in English
| MEDLINE
| ID: mdl-12031336
ABSTRACT
A series of phthalimide acid derivatives was synthesized and evaluated as leukotriene D(4) receptor antagonists. The tetrazolephthalimide LASSBio 552 (7) was shown to be able to inhibit the contractile activity induced by 100 nM of LTD(4) in guinea-pig tracheal strips with an IC(50) = 31.2 microM. In addition, LASSBio 552 (7) has been showed to present a better efficacy than zafirlukast (1) used as standard.
