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1.
J Appl Oral Sci ; 17(3): 248-53, 2009.
Article in English | MEDLINE | ID: mdl-19466261

ABSTRACT

OBJECTIVE: Follicular dendritic cells (FDCs) and interdigitating dendritic cells (IDCs) are dendritic cells found in lymphoid follicles, reactive follicles and in lymphomas. The goal of this study was to evaluate the presence and distribution of FDCs and IDCs in oral lymphomas. MATERIAL AND METHODS: Immunohistochemistry reactions were applied to 50 oral lymphomas using the antibodies anti-CD21, anti-CD35 and anti-caldesmon to FDCs, and anti-S100 protein to IDCs. Caldesmon+/FDCs and S100+/IDCs were quantified in Imagelab software. RESULTS: FDCs revealed by CD21 and CD35 were positively stained in two cases of diffuse large B-cell lymphoma, one MALT lymphoma, and in one case of mantle cell lymphoma. FDCs were immunopositive to caldesmon in all cases, as well as IDCs to S100 protein. Burkitt lymphoma presented a lower amount of caldesmon+/FDCs and S100+/IDCs than diffuse large B-cell lymphoma and plasmablastic lymphoma of the oral mucosa type. CONCLUSIONS: The microenvironment determined by neoplastic lymphoid cells in oral lymphomas is responsible by the development and expression of dendritic cells types.


Subject(s)
Dendritic Cells, Follicular/chemistry , Dendritic Cells/chemistry , Lymphoma, Non-Hodgkin/chemistry , Mouth Neoplasms/chemistry , Calmodulin-Binding Proteins/analysis , Humans , Immunohistochemistry , Lymphoma, B-Cell, Marginal Zone/chemistry , Lymphoma, B-Cell, Marginal Zone/pathology , Lymphoma, Large B-Cell, Diffuse/chemistry , Lymphoma, Large B-Cell, Diffuse/pathology , Lymphoma, Mantle-Cell/chemistry , Lymphoma, Mantle-Cell/pathology , Lymphoma, Non-Hodgkin/pathology , Mouth Neoplasms/pathology , Receptors, Complement 3b/analysis , Receptors, Complement 3d/analysis , S100 Proteins/analysis
2.
Head Neck Pathol ; 1(2): 178-80, 2007 Dec.
Article in English | MEDLINE | ID: mdl-20614272

ABSTRACT

Neoplasms of salivary glands represent a small group among the diseases involving the head and neck complex. In this group, the pleomorphic adenoma is the most frequent neoplasm, yet involves the submandibular gland in only 12.3% of cases. A patient presenting a swelling in the region of the submandibular gland was submitted to an incisional biopsy, where a fragment of the gland and one juxtaposed node were removed. Histologically they were defined as pleomorphic adenoma. Later, the patient was submitted to submandibulectomy and two other nodes were found close to the gland and removed. All specimens were histologically defined as pleomorphic adenoma. This multicentric finding is of great interest, perhaps explaining the recurrence rate of this neoplasm. The patient is in continuous follow-up and has not presented signs of recurrence.


Subject(s)
Adenoma, Pleomorphic/pathology , Submandibular Gland Neoplasms/pathology , Submandibular Gland/pathology , Adenoma, Pleomorphic/surgery , Adult , Female , Humans , Neoplasms, Multiple Primary , Submandibular Gland/surgery , Submandibular Gland Neoplasms/surgery , Treatment Outcome
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