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1.
Dent Traumatol ; 38(5): 356-366, 2022 Oct.
Article in English | MEDLINE | ID: mdl-35583858

ABSTRACT

BACKGROUND/AIMS: Oral and maxillofacial trauma (OMFT) is a public health problem due to its high occurrence and demand for resources for its management and the financial and social impact of OMFT victims on the health system. The aim of this study was to conduct an 8-year prospective analysis of OMFT cases from an emergency service. MATERIALS AND METHODS: A hospital-based 8-year prospective study on OMFT and associated factors was performed on data from December 2011 to December 2019. Data regarding sociodemographic (gender, age, and skin color) and socio-economic profiles (educational level, family income, and occupation), OMFT profile (etiology, OMFT type, and treatment), associated factors [alcohol consumption and personal protective equipment (PPE) use], OMFT occurrence (injury day and hour), length of hospital stay, and cost were collected. Descriptive and inferential analyses of data were performed. RESULTS: Most OMFT cases involved men with low schooling and family income, resulting from traffic accidents. OMFT severity was associated with longer hospital stay, higher hospital costs and nonuse of PPE, midface fractures (mainly orbital-zygomatic fractures), closed reduction, and open reduction/internal fixation. Traffic accidents were the main cause of longer hospital stays for victims aged 41-60 years with better socio-economic status compared with cases that had higher hospital costs. In general, higher hospital costs were associated with victims of violence under 40 years of age, with low schooling and farmers. Alcohol consumption and non-use of PPE also contributed to increasing the length of hospital stay. CONCLUSION: Oral and maxillofacial trauma severity was associated with longer hospital stay and higher hospital costs. Associated factors such as alcohol consumption and non-use of PPE contributed to increase the length of hospital stay and OMFT severity.


Subject(s)
Maxillofacial Injuries , Orbital Fractures , Accidents, Traffic , Humans , Male , Maxillofacial Injuries/etiology , Prospective Studies , Retrospective Studies , Violence
2.
J Craniofac Surg ; 33(8): 2455-2459, 2022.
Article in English | MEDLINE | ID: mdl-35119397

ABSTRACT

ABSTRACT: This systematic review was carried out to determine if maxillomandibular fixation, used in the treatment of maxillary fractures, interferes with respiratory function, and appraised studies that evaluated pulmonary function using spirometry on patients with and without maxillomandibular fixation. Searches were conducted on the following databases: Medline/Pubmed, Embase, Cochrane, Web of Science, Scopus, and Scielo, in addition to a search of the grey literature and a manual search. Five studies were included in the qualitative analysis, but it was not possible to conduct a quantitative study due to the lack of data. Forced vital capacity, forced expiratory volume in the first second, the ratio of these values, and peak expiratory flow were the parameters studied. In all the studies included in this review, it was possible to observe the lowest respiratory parameter values during maxillomandibular fixation and, after removal, normal respiratory function was restored. Accordingly, it was possible to conclude that maxillo-mandibular fixation temporarily affects respiratory function, during use, but it is restored on removal, therefore, not precluding its use on healthy patients who have good nasal breathing prior to the procedure. However, in patients suffering from some form of respiratory limitation or pulmonary disease, and also mouth breathers, maxillomandibular fixation should not be used so as to avoid more severe respiratory complications, underlining the importance of preoperative pulmonary evaluation.


Subject(s)
Jaw Fixation Techniques , Humans , Vital Capacity , Forced Expiratory Volume , Spirometry , Respiratory Function Tests/methods
3.
Ann Plast Surg ; 85(6): 645-649, 2020 12.
Article in English | MEDLINE | ID: mdl-33165116

ABSTRACT

INTRODUCTION: Peripheral nerves transmit nerve signals between periphery and the spinal cord or brain stem. Its function can be compromised by trauma to the nerve, such as those that occur in surgical procedures such as orthognathic surgery. Depending on the type of injury, treatment may be proposed, but this is still a controversial point in literature. Alternative methods that assist in the treatment of paresthesia should be studied, and in this context, selegiline hydrochloride seems to be a promising drug. AIM: Based on the above, the aim of this study was to evaluate the effectiveness of selegiline hydrochloride in the treatment of facial sensory changes resulting from nerve injuries in patients undergoing maxillary orthognathic surgery. METHODS: This was a double-blind randomized clinical trial with the voluntary participation of individuals who underwent orthognathic surgery. The facial sensitivity of these patients was evaluated by 2-point discrimination tests and directional perception in the region related to the lower alveolar nerve. Tests were comparatively applied at times T0 (before surgery), T8 (8 days after surgery), T15 (15 days after surgery), T30 (30 days after surgery), T60 (60 days after surgery), and T90 (90 days after surgery). RESULTS: The mean age of patients was 31.14 years. With the comparative analysis of the 2-point static test on the chin, difference was observed between groups at times T15 (P = 0.007), T30 (P = 0.010), and T90 (P = 0.027) in the intergroup evaluation. Regarding results of the comparative analysis of the 2-point static test on the lip, difference was observed between groups at times T30 (P = 0.023), T60 (P < 0.001), and T90 (P = 0.005) in the intergroup evaluation. In the direction test on the chin, difference was observed between groups at times T30 (P = 0.015), T60 (P = 0.001), and T90 (P < 0.001) in the intergroup evaluation. CONCLUSIONS: Selegiline hydrochloride has shown promising results in the treatment of neurosensory disorders resulting from maxillary orthognathic surgery.


Subject(s)
Orthognathic Surgical Procedures , Trigeminal Nerve Injuries , Adult , Chin , Humans , Mandible , Mandibular Nerve , Mandibular Osteotomy , Selegiline , Trigeminal Nerve Injuries/drug therapy
4.
J Contemp Dent Pract ; 21(6): 696-700, 2020 Jun 01.
Article in English | MEDLINE | ID: mdl-33025942

ABSTRACT

AIM: The aim of this study was to evaluate the available evidence to identify the influence of pterygomaxillary disjunction on the result of surgically assisted maxillary expansion. BACKGROUND: LeFort I type osteotomy with disjunction of the pterygomaxillary suture is a procedure widely used in maxillofacial surgery. However, the need for its performance during surgically assisted maxillary expansions has been discussed in literature, since serious complications can be caused during this stage. REVIEW RESULTS: Systematic review of articles was performed using three databases (PubMed, Web of Science, and Cochrane) published until May 2019. After applying the selection criteria, five articles were included in the systematic review, with a total of 141 patients. Meta-analysis showed the absence of significant difference between intervention and control groups in the preoperative period (standardized mean difference = -0.28; confidence interval, CI 95% = -0.81, 0.26; p = 0.31) and postoperative period (standardized mean difference = -0.12; 95% CI = -0.65, 0.42; p = 0.66). In general, the heterogeneity of statistical estimates was low (I2 = 0%). CONCLUSION: No statistically significant difference was observed between control group (without pterygomaxillary disjunction) and intervention group (with pterygomaxillary disjunction). CLINICAL SIGNIFICANCE: Based on the data analyzed in this systematic review, it could be concluded that pterygomaxillary disjunction is not a mandatory step to achieve satisfactory maxillary expansion. Thus, not performing pterygomaxillary disjunction can prevent complications and reduce surgical time.


Subject(s)
Maxilla , Palatal Expansion Technique , Humans , Maxilla/surgery , Osteotomy, Le Fort
5.
Rev. cuba. estomatol ; 55(4): 1-9, oct.-dic. 2018. tab
Article in English | CUMED | ID: cum-73786

ABSTRACT

Introduction: Despite the vast literature reporting the prevalence of oral and maxillofacial diseases in the last decades, few studies have focused on lesions biopsied in the pediatric population. Objective: To determine the prevalence of oral and maxillofacial lesions that were biopsied in children and adolescents aged 0-19 years. Methods: Observational and descriptive study. We carried out a retrospective review of 862 reports of pathological examinations performed in an oral pathology laboratory of the northeast of Brazil, during the period from March 2001 to December 2009. The categories were neoplasms, hyperplastic/reactionary lesions, salivary gland lesions, bone lesions, healthy tissues and teeth, oral mucosal lesions, cystic lesions, odontogenic tumors, periapical inflammation, dental alteration and conclusive diagnosis. Results: The epidemiological profile of patients was characterized by females (53.24 percent), Caucasian (45.12 percent), with a mean age of 13.06 years. Salivary gland lesions were the category with the largest number of cases (182), and mucocele was the most prevalent histopathological diagnosis (18.44 percent), with an average size of 1.97 cm. Most cases were asymptomatic (70.88 percent). Conclusions: This study showed a predominance of lesions diagnosed as benign, the most prevalent lesions were associated with the salivary gland. Females were the most affected(AU)


Introducción: A pesar de la gran cantidad de literatura que informa sobre la prevalencia de enfermedades bucales y maxilofaciales en las últimas décadas, pocos estudios se concentraron en las lesiones biopsiadas en la población pediátrica. Objetivo: Determinar la prevalencia de las lesiones bucales y maxilofaciales que fueron biopsiadas en los niños y adolescentes de 0 a 19 años. Métodos: Estudio observacional y descriptivo. Se realizó una revisión retrospectiva de 862 informes de los exámenes patológicos realizados en un laboratorio de Patología Oral del nordeste de Brasil, durante el período comprendido entre marzo de 2001 y diciembre de 2009. Las categorías fueron: neoplasias, hiperplásicas / lesiones reactivas, lesiones de las glándulas salivales, lesiones óseas, tejidos y dientes sanos, lesiones de la mucosa bucal, lesiones quísticas, tumores odontogénicos, inflamación periapical, alteración dental y diagnóstico concluyente. Resultados: El perfil epidemiológico de los pacientes se caracterizó por las mujeres (53,24 por ciento), de raza caucásica (45,12 por ciento) con una edad media de 13,06 años. Lesiones de las glándulas salivales fueron la categoría con el mayor número de casos (182), y el mucocele fue el diagnóstico histopatológico más frecuente (18,44 por ciento), con un tamaño medio de 1,97 cm. La mayoría de los casos fueron asintomáticos (70,88 por ciento). Conclusiones: Este estudio mostró un predominio de las lesiones diagnosticadas como benignas. Las lesiones más frecuentes se relacionaron con la glándula salival. Las mujeres fueron las más afectadas(AU)


Subject(s)
Humans , Female , Salivary Glands/injuries , Odontogenic Tumors , Maxillofacial Injuries/epidemiology , Mouth Diseases/epidemiology , Epidemiology, Descriptive , Retrospective Studies , Observational Study
6.
Rev. cuba. estomatol ; 55(4): 1-9, oct.-dic. 2018. tab
Article in English | LILACS | ID: biblio-991076

ABSTRACT

Introduction: Despite the vast literature reporting the prevalence of oral and maxillofacial diseases in the last decades, few studies have focused on lesions biopsied in the pediatric population. Objective: To determine the prevalence of oral and maxillofacial lesions that were biopsied in children and adolescents aged 0-19 years. Methods: Observational and descriptive study. We carried out a retrospective review of 862 reports of pathological examinations performed in an oral pathology laboratory of the northeast of Brazil, during the period from March 2001 to December 2009. The categories were neoplasms, hyperplastic/reactionary lesions, salivary gland lesions, bone lesions, healthy tissues and teeth, oral mucosal lesions, cystic lesions, odontogenic tumors, periapical inflammation, dental alteration and conclusive diagnosis. Results: The epidemiological profile of patients was characterized by females (53.24 percent), Caucasian (45.12 percent), with a mean age of 13.06 years. Salivary gland lesions were the category with the largest number of cases (182), and mucocele was the most prevalent histopathological diagnosis (18.44 percent), with an average size of 1.97 cm. Most cases were asymptomatic (70.88 percent). Conclusions: This study showed a predominance of lesions diagnosed as benign, the most prevalent lesions were associated with the salivary gland. Females were the most affected(AU)


Introducción: A pesar de la gran cantidad de literatura que informa sobre la prevalencia de enfermedades bucales y maxilofaciales en las últimas décadas, pocos estudios se concentraron en las lesiones biopsiadas en la población pediátrica. Objetivo: Determinar la prevalencia de las lesiones bucales y maxilofaciales que fueron biopsiadas en los niños y adolescentes de 0 a 19 años. Métodos: Estudio observacional y descriptivo. Se realizó una revisión retrospectiva de 862 informes de los exámenes patológicos realizados en un laboratorio de Patología Oral del nordeste de Brasil, durante el período comprendido entre marzo de 2001 y diciembre de 2009. Las categorías fueron: neoplasias, hiperplásicas / lesiones reactivas, lesiones de las glándulas salivales, lesiones óseas, tejidos y dientes sanos, lesiones de la mucosa bucal, lesiones quísticas, tumores odontogénicos, inflamación periapical, alteración dental y diagnóstico concluyente. Resultados: El perfil epidemiológico de los pacientes se caracterizó por las mujeres (53,24 por ciento), de raza caucásica (45,12 por ciento) con una edad media de 13,06 años. Lesiones de las glándulas salivales fueron la categoría con el mayor número de casos (182), y el mucocele fue el diagnóstico histopatológico más frecuente (18,44 por ciento), con un tamaño medio de 1,97 cm. La mayoría de los casos fueron asintomáticos (70,88 por ciento). Conclusiones: Este estudio mostró un predominio de las lesiones diagnosticadas como benignas. Las lesiones más frecuentes se relacionaron con la glándula salival. Las mujeres fueron las más afectadas(AU)


Subject(s)
Humans , Female , Salivary Glands/injuries , Odontogenic Tumors/diagnostic imaging , Maxillofacial Injuries/epidemiology , Mouth Diseases/epidemiology , Epidemiology, Descriptive , Retrospective Studies , Observational Study
7.
Eur Arch Otorhinolaryngol ; 274(2): 1089-1095, 2017 Feb.
Article in English | MEDLINE | ID: mdl-27747382

ABSTRACT

Odontogenic tumors (OTs) are important lesions of the gnathic bones due to their clinicopathological heterogeneity and variable biological behavior; therefore, epidemiological studies are needed to outline the incidence and behavior of these tumors. To evaluate the incidence and epidemiological profile of ameloblastoma (AMB) and keratocystic odontogenic tumor (KCOT) from an oral pathology service, and correlate morphological findings of these tumors with the immunoexpression of a cellular proliferation marker (Ki-67), a retrospective study (2002-2012) was conducted to characterize demographic, clinical, radiological, and morphological data of AMBs and KCOTs. Then, a representative sample composed of 49 cases of each tumor was selected to perform immunohistochemical (IHC) analysis of Ki-67 through the streptavidin biotin peroxidase technique. For statistical analysis, we used Fisher's exact test (p < 0.05). A total of 279 OTs were found in the service, in which 91 (32.6%) were AMB and 98 (35 %) were KCOT. Most cases occurred in white women, and the average age of patients with AMB and KCOT was 32 and 33 years, respectively. The maxilla-mandible ratio was 1:6 and 1:3.6 for AMB and KCOT, respectively. Regarding IHC analysis, AMB and KCOT had similar levels of cellular proliferation. However, KCOTs with intense inflammation showed higher Ki-67 expression (p < 0.001). Recurrent cases had similar Ki-67 immunoexpression. The demographic profile of the studied tumors corroborates with data reported in the literature, and the levels of cellular proliferation were similar in both tumors, although the inflammation seems to induce a differential proliferative behavior in KCOT.


Subject(s)
Mandibular Neoplasms/pathology , Maxillary Neoplasms/pathology , Odontogenic Tumors/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Ameloblastoma/epidemiology , Ameloblastoma/metabolism , Ameloblastoma/pathology , Brazil/epidemiology , Cell Proliferation , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Immunohistochemistry , Incidence , Ki-67 Antigen/metabolism , Male , Mandibular Neoplasms/epidemiology , Mandibular Neoplasms/metabolism , Maxillary Neoplasms/epidemiology , Maxillary Neoplasms/metabolism , Middle Aged , Odontogenic Tumors/epidemiology , Odontogenic Tumors/metabolism , Retrospective Studies , Young Adult
9.
J Dent Child (Chic) ; 82(2): 84-90, 2015.
Article in English | MEDLINE | ID: mdl-26349795

ABSTRACT

PURPOSE: The purpose of this study was to evaluate the profile of pediatric oral lesions in northeastern Brazil. METHODS: Biopsy records of oral lesions were retrieved from patients aged zero to 18 years who were treated over 18 years in two university hospitals in northeastern Brazil. Routine pathological sections were re-examined and classified into six groups: (1) odontogenic and nonodontogenic cysts; (2) odontogenic tumors; (3) salivary gland pathology; (4) nonodontogenic tumors and tumor-like lesions; (5) bone pathology; and (6) miscellaneous. RESULTS: From a total of 4,690 oral biopsies, 564 (12 percent) were from children and adolescents. The largest number of cases was salivary gland pathology, followed by nonodontogenic tumors and tumor-like lesions. The most common oral biopsies were mucocele, pericoronal dental follicle, pyogenic granuloma, dentigerous cyst, and odontoma. Only three cases of malignant tumors were observed. Our results were similar to most studies. CONCLUSIONS: Although malignant tumors comprised a small portion of the pediatric oral biopsies, the possibility of their occurrence in children and adolescents should not be overlooked.


Subject(s)
Stomatognathic Diseases/epidemiology , Adolescent , Biopsy , Brazil/epidemiology , Child , Child, Preschool , Female , Hospitals, University , Humans , Infant , Infant, Newborn , Male , Retrospective Studies , Stomatognathic Diseases/pathology
10.
J Oral Maxillofac Pathol ; 18(Suppl 1): S86-9, 2014 Sep.
Article in English | MEDLINE | ID: mdl-25364187

ABSTRACT

CONTEXT: Focal fibrous hyperplasia, also known as irritation or traumatic fibroma, is a reactive, inflammatory hyperplastic lesion of the connective tissue. AIM: The aim of this study is to perform a retrospective study of a focal fibrous hyperplasia of 18 years. MATERIALS AND METHODS: We retrospectively reviewed 193 cases of focal fibrous hyperplasia of the oral cavity from the medical and histological reports of the Department of Oral Pathology, Pernambuco University, Brazil, during the period between January 1992 and December 2009. SETTINGS AND DESIGN: Data with regard to age, gender, location, size of the lesion (equal to or less than 1 cm, between 1 and 2 cm and greater than 2 cm), pain, history of trauma, treatment, length of follow-up (from diagnosis to release or last review) and recurrence, were collected. RESULTS: The most commonly affected site was the buccal mucosa (n = 119, 61.7%). Almost two-thirds of the cases were concentrated from the second to the fifth decade of life. Females were more affected than men and a history of trauma was related by 90.7% of the patients. Two recurrences were notified (1.0%). CONCLUSION: Further studies are needed on the distribution of the lesion in different ethnic and geographical populations. The influence of sex hormones on the development of focal fibrous hyperplasia must be clarified.

11.
Oncol Lett ; 5(6): 1909-1914, 2013 Jun.
Article in English | MEDLINE | ID: mdl-23833665

ABSTRACT

Due to the frequent presence of inflammation in cases of carcinoma and its use as a parameter for the assessment of tumor aggressiveness, the role of inflammation in oral carcinogenesis was investigated. This was performed by evaluating the expression of cellular markers, cytokines and nuclear transcription factors that identify the cells that participate in the antitumor defense in cases of oral epithelial dysplasia (OED) and oral squamous cell carcinoma (OSCC). A semi-quantitative immunohistochemical analysis was performed for the transcription factors cluster of differentiation 8 (CD8), forkhead box P3 (FOXP3), transforming growth factor (TGF)-ß, tumor necrosis factor (TNF)-α and nuclear factor κ-light chain enhancer of activated B-cells (NF-κB), in cases of OED and OSCC. CD8, TGF-ß, TNF-α and NF-κB participated in the processes of tumor transformation and progression. The presence of inflammatory infiltrate in cases of OED favors the transformation and invasion process when stromal TNF-α and NF-kB are overexpressed, as NF-kB activated by TNF-α during inflammation predisposes the lesion to transformation, functioning as a link between inflammation and cancer. The control of these inflammatory mediators may prevent malignant transformation in the oral cavity.

12.
J Dent Child (Chic) ; 80(1): 41-6, 2013.
Article in English | MEDLINE | ID: mdl-23595244

ABSTRACT

PURPOSE: The purpose of this study was to determine the prevalence and predicitve factors of dental anxiety among Brazilian adolescents. METHODS: This was a cross-sectional study of a random sample of 340 Brazilian adolescents, done between 2005 and 2010. Corah's Dental Anxiety Scale and an objective questionnaire were used to determine the degree of dental anxiety. RESULTS: The prevalence of moderate to severe dental anxiety was approximately 18%. Dental anxiety was correlated with the following factors: gender (P<.05), age group (P<.001), degree of schooling (P<.001), access to newspapers and/or the Internet (P<02), oral hygiene frequency (P=.005), visits to the dentist (P<.02), reason for last visit to the dentist (P<.001), and experience with dental pain (P=.002). CONCLUSIONS: Dental fear and anxiety in Brazilian adolescents are associated with lack of economic resources, negligence of oral health, low educational level, female gender, and younger age.


Subject(s)
Dental Anxiety/epidemiology , Dental Anxiety/etiology , Adolescent , Adolescent Behavior , Age Factors , Analysis of Variance , Brazil , Child , Cross-Sectional Studies , Dental Care/adverse effects , Educational Status , Female , Humans , Logistic Models , Male , Prevalence , Sex Factors , Surveys and Questionnaires
13.
J Craniofac Surg ; 24(2): e134-6, 2013 Mar.
Article in English | MEDLINE | ID: mdl-23524811

ABSTRACT

The calcifying cystic odontogenic tumor or Gorlin cyst is an uncommon lesion with a variable clinical behavior and considerable histopathologic diversity. The authors report a case of calcifying cystic odontogenic tumor that was being treated as a maxillary sinus mucocele. The possibility of mimicking numerous odontogenic and nonodontogenic lesions makes the calcifying cystic odontogenic tumor difficult for a clinical diagnosis. The present case demonstrates that a specific knowledge in oral pathology is required to differentiate odontogenic lesions.


Subject(s)
Maxillary Neoplasms/diagnosis , Maxillary Neoplasms/surgery , Odontogenic Cyst, Calcifying/diagnosis , Odontogenic Cyst, Calcifying/surgery , Aged , Diagnosis, Differential , Female , Humans , Maxillary Neoplasms/pathology , Mucocele/diagnosis , Odontogenic Cyst, Calcifying/pathology , Radiography, Panoramic , Tomography, X-Ray Computed
14.
Int J Med Sci ; 8(8): 659-66, 2011.
Article in English | MEDLINE | ID: mdl-22135612

ABSTRACT

The aim of the present study was to assess the clinical and radiographic repercussions of surgically assisted maxillary expansion on the septum, nasal cavity and nasal conchae. The sample was made up of 15 patients with skeletal maturity (9 females and 6 males between 16 and 45 years of age) and maxillary transverse deficiency. Assessments were performed through anterior rhinoscopy and frontal cephalometric radiographs on three occasions: (T0) preoperative period, (T1) locking of the expander and (T2) six months following the locking procedure. An increase was observed in the basal portion of the pyriform aperture and distances between the lateral wall of the basal portion of the pyriform aperture and the septum. The radiographic exam revealed that the nasal septum did not undergo any statistically significant change in its position. Moreover, no significant changes in the position of the nasal septum or nasal conchae were detected throughout the three evaluation times. The results suggest that surgically assisted maxillary expansion is capable of widening the basal portion of the pyriform aperture, with little repercussion on the anterior position of the nasal septum and inferior nasal conchae.


Subject(s)
Maxillary Sinus/surgery , Nose/anatomy & histology , Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult
15.
Braz J Otorhinolaryngol ; 77(4): 447-454, 2011.
Article in English, Portuguese | MEDLINE | ID: mdl-21860970

ABSTRACT

UNLABELLED: Because of its biocompatibility and osteoconductive properties, calcium-phosphate cement has been used as bone surrogate. OBJECTIVE: The purpose of this study was to do a histomorphometric comparison of bone regeneration using hydroxyapatite biphasic ceramic, calcium-phosphate cement and autogenous bone graft. STUDY DESIGN: Prospective and laboratorial experiment. MATERIALS AND METHODS: Two 5mm in diameter cavities (left and right--test and control) were made in the parietal bone of 72 rats. The GI, GII, GIII and GIV test cavities were filled with calcium-phosphate cement, biphasic ceramic hydroxyapatite, autogenous bone graft and blood. The animals were killed at 30, 60 and 90 days and the specimens underwent histomorphometric analysis. RESULTS: The results showed that autogenous bone graft treated defects had significantly more new bone at 30 days compared to other test groups. Within 60 and 90 days, bone formation was more significant in the test groups GI, GII and GIII; GI and GII encompassed larger areas. Throughout the evaluation periods, GII tests showed more bone formation when compared to GI. CONCLUSIONS: Biomaterials depicted a significantly increase in bone content, when compared to autogenous bone graft, concerning bone regeneration.


Subject(s)
Biocompatible Materials/therapeutic use , Bone Cements/therapeutic use , Bone Regeneration , Bone Substitutes/therapeutic use , Calcium Phosphates/therapeutic use , Durapatite/therapeutic use , Animals , Bone Transplantation , Ceramics/therapeutic use , Male , Parietal Bone/surgery , Prospective Studies , Rats , Rats, Wistar , Time Factors
16.
J Craniofac Surg ; 22(2): 589-91, 2011 Mar.
Article in English | MEDLINE | ID: mdl-21403540

ABSTRACT

Osteoma is an osteoblastic benign tumor characterized by the proliferation of either compact or cancellous bone. In the jaws, the most of cases reported in the literature presented as peripheral solitary lesions, involving preferably the posterior region of the mandible. However, central osteomas are quite rare, especially in the maxillary bone. The purpose of this article was to present the clinical, radiographic, surgical, and histologic features of a solitary central osteoma of the maxilla with involvement of the paranasal sinus and to review the literature for central osteomas located in the jaws. Our clinical report participates to literature as the 12th case of central osteoma in the jaws and the fourth case in the maxillary bone.


Subject(s)
Maxillary Neoplasms/diagnostic imaging , Maxillary Neoplasms/surgery , Osteoma/diagnostic imaging , Osteoma/surgery , Paranasal Sinus Neoplasms/diagnostic imaging , Paranasal Sinus Neoplasms/surgery , Adult , Biopsy , Diagnosis, Differential , Humans , Male , Maxillary Neoplasms/pathology , Osteoma/pathology , Paranasal Sinus Neoplasms/pathology , Radiography, Panoramic
17.
Oncol Lett ; 2(6): 1225-1231, 2011 Nov.
Article in English | MEDLINE | ID: mdl-22848292

ABSTRACT

The aim of the present study was to assess the suppressant role of the inflammatory infiltrate in oral carcinogenesis through the immunohistochemical expression of CD8 and FOXP3 and to discuss how representative this expression proved, as well as other parameters considered to be of prognostic value. A total of 20 cases of oral epithelial dysplasia and 40 cases of oral squamous cell carcinoma were selected. The criteria suggested by the World Health Organization were used for the histological grading of dysplasia. For carcinoma, a binary method was developed for the present study using parameters such as type of invasion, maturity, presence of epithelial masses and dysmorphism of the masses. Immunohistochemical analysis was performed for assessment of the expression of anti-CD8 and anti-FOXP3 in cases of dysplasia and carcinoma. Although the inflammatory infiltrate was more intense in the majority of carcinomas, it exercised a protective role in the dysplasia cases, as CD8 expression was significantly greater. Although a correlation was found between CD8 and the intensity of the inflammatory infiltrate in the carcinoma cases, CD8 demonstrated >5% expression in only 32.5% of the cases, compared to 80% of the dysplasia cases. Thus, we suggest that the inflammatory infiltrate should not be used as a parameter in routine examinations, as it plays different roles in the various stages of carcinogenesis. The histological grading system for malignancy employed in the present study is indicated for the assessment of oral squamous cell carcinoma.

18.
Quintessence Int ; 41(2): 99-102, 2010 Feb.
Article in English | MEDLINE | ID: mdl-20165741

ABSTRACT

Hereditary gingival fibromatosis is characterized by a slow, progressive increase in the gingival tissue that develops as either an isolated disorder or as part of the clinical characteristics of diverse syndromes. The present case report describes a Brazilian family with individuals from three generations affected. The proposed treatment was maxillary and mandibular gingivectomy with 12 months of monitoring.


Subject(s)
Fibromatosis, Gingival/genetics , Child , Chromosomes, Human, Pair 2 , Chromosomes, Human, Pair 5 , Female , Fibromatosis, Gingival/surgery , Gingivectomy , Humans , Male , Middle Aged , Pedigree
19.
Acta odontol. venez ; 48(4)2010. tab, graf
Article in Spanish | LILACS | ID: lil-682933

ABSTRACT

Los odontomas son considerados el tipo más común de tumores odontogénicos, generalmente observados en exámenes radiográficos, siendo esa, la base de diagnóstico de muchos estudios. El objetivo del presente tarbajo fue la realización de un análisis retrospectivo descriptivo en el periodo comprendido entre enero de 1992 a enero de 2007 a partir de estudios anatómico-patológicos. Fueron evaluados 238 casos de tumores odontogénicos, de los cuales 44% eran odontomas. Los resultados demostraron que 68,52% de los casos ocurrieron en el género femenino, siendo la 1ª y 2ª décadas de vida las más prevalentes (46,3%). La mayoría de los casos (81,48%) se mostró asintomático, con una discreta predilección por el maxilar (57,41%). El tipo compuesto fue más frecuente que el complejo, con 53,7% y 46,3% de los casos, respectivamente. El presente estudio fue basado en diagnóstico anatomo-patológico, diferenciándose así de estudios ya publicados, que se basan en análisis radiográficos. A pesar de las diferencias entre los estudios sobre género, edad, extensión, localización y síntomas, varias similitudes fueron observadas. Nuevos estudios retrospectivos en diferentes poblaciones son necesarios para promover una mejor comprensión de los odontomas


Odontomas are considered the most common type of odontogenic tumors, usually observed in radiographic examination, which is the basis of diagnosis in many studies. The authors performed a descriptive retrospective analysis in the period from January 1992 to January 2007 from the Pernambuco University Oral Pathology Laboratory's records. Two hundred and thirty eight cases of odontogenic tumors were registered, in which 44% were odontomas. Results showed that 68.52% of the cases were female, with 1st and 2nd decades of life being most prevalent (46.3%). The majority of the cases (81.48%) were asymptomatic, with a discreet predilection to the maxilla (57.41%). The compound type was more frequent than the complex, with 53.7% and 46.3% of the cases, respectively. The present study was based in histological diagnosis, differently from other already published studies, which were based in radiographic analysis. In spite of the differences between the studies in gender, age, extension, location and symptoms, several similarities were observed. New retrospective studies in different populations are necessary in order to provide a better understanding of odontomas


Subject(s)
Humans , Female , Maxillary Neoplasms/diagnosis , Odontoma/diagnosis , Odontoma/pathology , Radiography, Dental/methods , Odontogenic Tumors/diagnosis , Odontogenic Tumors/pathology , Dentistry , Surgery, Oral
20.
Acta odontol. venez ; 47(4): 256-264, dic. 2009. ilus
Article in Spanish | LILACS | ID: lil-630233

ABSTRACT

Los tumores odontogénicos comprenden un grupo complejo de lesiones de comportamiento clínico y tipos histológicos diversos. Algunas de estas lesiones son neoplasias verdaderas y raramente pueden presentar un comportamiento maligno. Otras pueden representar malformaciones semejantes a tumores (hamartomas). El fibroma ameloblástico es considerado un verdadero tumor mixto, en el cual los tejidos epitelial y mesenquimal son neoplásicos. El presente trabajo tiene por objetivo describir el caso de una paciente perteneciente a la segunda década de vida, asintomática donde fue diagnosticado un fibroma ameloblástico siendo realizado tratamiento quirúrgico para remoción de la lesión; así como realizar diversas consideraciones con respecto a las principales características clínicas de esta neoplasia, haciendo referencias al diagnóstico y su tratamiento clínico.


Os tumores odontogênicos compreendem um grupo complexo de lesões de comportamento clínicos e tipos histológicos diversos. Algumas destas lesões são verdadeiras neoplasias e raramente podem apresentar um comportamento maligno. Outras podem representar malformações semelhantes a tumores (hamartomas). O fibroma ameloblástico é considerado um verdadeiro tumor misto, no qual os tecidos epitelial e mesenquimal são neoplásicos. O presente trabalho têm por objetivo descrever o caso de uma paciente pertencente a segunda década de vida, assintomática onde foi diagnósticada a lesão acima citada, sendo posteriormente realizado tratamento cirúrgico para remoçao da lesão; e fazer diversas considerações a respeito das principais características clínicas desta neoplasia, fazendo referências ao diagnóstico e seu tratamento clínico.


Odontogenic tumors are a complex group of injuries that presents several types of clinical behaviors and histological types. Some of these tumors are true neoplasms and rarely present in malignant forms. Others can present tumors-like malformations (hamartomas). The ameloblastic fibroma is considered a true mixed odontogenic tumor, in which epithelial and mesenchymal Tissues are neoplasics. The aim of this study was to describe a case of a second -decade of life patient, asymptomatic, that was diagnosed the lesion above cited, being latter carried surgical treatment for tumor removal. It was also done considerations regarding the main clinical characteristics of this neoplasm, and made references to the diagnosis and its clinical treatment.

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