ABSTRACT
The aim of this study was to evaluate the possible association between polymorphisms in the catechol-O-methyltransferase (COMT) and ß2-adrenergic receptor (ADRB2) genes and muscular temporomandibular disorders (TMD). This was a case-control study. Individuals were evaluated using the Research Diagnostic Criteria for Temporomandibular Disorders and were divided into three groups: unaffected (no TMD) (n=154); exclusively muscular TMD (n=49); exclusively articular TMD (n=49). Genomic DNA was obtained from saliva samples, and single nucleotide polymorphisms in the COMT (rs165774, rs6269, rs9332377) and ADRB2 (rs2053044, rs1042713, rs1042714) genes were investigated. The TT genotype for the COMT rs9332377 gene was highly associated with the presence of muscular TMD (P= 0.03). With respect to the ADRB2 gene, the non-polymorphic AA genotype in the rs1042713 region was more prevalent in the articular TMD group than in the muscular TMD group (P= 0.05). This study supports the hypothesis that alterations in the COMT and ADRB2 genes influence the muscular pathophysiology.
Subject(s)
Catechol O-Methyltransferase , Temporomandibular Joint Disorders , Brazil , Case-Control Studies , Genotype , Humans , Polymorphism, Single Nucleotide , Receptors, Adrenergic, beta-2ABSTRACT
Los trastornos temporomandibulares (TTM) se pueden definir como un conjunto de condiciones dolorosas y/o disfuncionales en los músculos masticatorios y/o en la articulación temporomandibular (ATM). Comúnmente afectan a las mujeres durante los años reproductivos y su prevalencia disminuye bruscamente con la edad. Debido a la compleja naturaleza multifactorial de los TTM, es fundamental la investigación interdisciplinar amplia, básica y clínica que permita el desarrollo de estrategias basadas en evidencias capaces de prevenir, diagnosticar y tratar estos trastornos crónicos de manera más eficaz y segura (AU)
Temporomandibular disorders (TMD) can be defined as a set of painful and/or dysfunctional conditions, involving the masticatory muscles and/or the temporomandibular joint (TMJ). hey commonly affect women during the reproductive years and its prevalence drastically decreases as result from ageing. Due to the complex multifactorial nature of TMD, it is essential the broad interdisciplinary research, basic and clinical, that supports developing evidence-based strategies being able to prevent, diagnose and manage these chronic conditions in a more effective and safe way (AU)
