Subject(s)
Bariatric Surgery , Cholelithiasis , Cholecystectomy , Cholelithiasis/complications , Cholelithiasis/surgery , HumansABSTRACT
No disponible
Subject(s)
Humans , Male , Adult , Meningeal Carcinomatosis/complications , Meningeal Carcinomatosis/drug therapy , Adenocarcinoma/complications , Adenocarcinoma/drug therapy , Meningeal Carcinomatosis/pathology , Meningeal Carcinomatosis/surgery , Prognosis , Rectal Neoplasms/complications , Rectal Neoplasms/pathologyABSTRACT
We present the case report of a twenty-five-year-old Moroccan male patient who suffered from leptomeningeal carcinomatosis related to a signet-ring cell carcinoma of the rectum. He presented to the emergency department with abdominal pain, constipation, weight loss and rectal bleeding. The rectal examination showed a rectal tumor and a CT scan revealed a large bowel obstruction due to rectal diffuse thickening. An emergency transverse colostomy was performed, with a rectal biopsy and a cytological sample collection. The pathology analysis showed a signet-ring cell carcinoma from the rectum. The staging evaluation was completed and neoadjuvant chemotherapy and radiotherapy were offered to the patient. Two months later, he developed neurological signs of leptomeningeal involvement which was confirmed by a lumbar puncture. Then, the patient received systemic and intrathecal chemotherapy but later died. This case shows the tendency of colorectal signet-ring cell carcinomas to cause leptomeningeal metastasis, even in young patients.
Subject(s)
Carcinoma, Signet Ring Cell/secondary , Chemotherapy, Adjuvant/methods , Colorectal Neoplasms/pathology , Meningeal Carcinomatosis/secondary , Adult , Carcinoma, Signet Ring Cell/diagnostic imaging , Carcinoma, Signet Ring Cell/drug therapy , Colorectal Neoplasms/diagnostic imaging , Colorectal Neoplasms/drug therapy , Fatal Outcome , Humans , Intestinal Obstruction , Magnetic Resonance Imaging , Male , Meningeal Carcinomatosis/diagnostic imaging , Meningeal Carcinomatosis/drug therapy , UltrasonographyABSTRACT
We present three young patients diagnosed with signet ring cell carcinoma of the stomach. All had in common the smoking rather than the injecting route of administration of drugs, such as heroin. In the smoking route, pieces of nickel scourer are mixed with the drug. This heavy metal has known carcinogenic effects. Chronic exposure of the gastric mucosa to nickel, from oropharynx, could be a risk factor for the development of gastric adenocarcinoma in heroin smoking addicts.
Subject(s)
Carcinoma, Signet Ring Cell/etiology , Carcinoma, Signet Ring Cell/pathology , Stomach Neoplasms/etiology , Stomach Neoplasms/pathology , Substance-Related Disorders/complications , Adult , Alcoholism/complications , Carcinoma, Signet Ring Cell/surgery , Cocaine-Related Disorders/complications , Humans , Male , Middle Aged , Smoking/adverse effects , Stomach Neoplasms/surgerySubject(s)
Antibodies, Monoclonal, Humanized/adverse effects , Antineoplastic Agents/adverse effects , Cardiac Output, Low/chemically induced , Esophageal Neoplasms/surgery , Esophagectomy/methods , Laparoscopy , Aged, 80 and over , Chemotherapy, Adjuvant , Humans , Male , Neoadjuvant Therapy , TrastuzumabABSTRACT
El manejo de los pólipos digestivos extracolónicos resulta controvertido en los pacientes con poliposis adenomatosa familiar (PAF). El tratamiento de los pólipos adenomatosos con displasia severa en el estómago mediante resecciones gástricas amplias puede dificultar el seguimiento posterior de la aparición de nuevos pólipos en el área duodenoyeyunal. Presentamos el caso excepcional de un varón de 45 años con PAF que desarrolló 2 pólipos adenomatosos sincrónicos, con displasia severa, uno en el antro gástrico y el otro en el yeyuno proximal. Se realizó una gastrectomía subtotal en «Y» de Roux y una resección del segmento yeyunal proximal, ante el diagnóstico preoperatorio de neoplasia gástrica con invasión de la pared (T2N0) (AU)
The management of extracolonic gastrointestinal polyps is controversial in patients with familial adenomatous polyposis (FAP). The treatment of adenomatous polyps with severe dysplasia in the stomach through wide gastric resections can hamper subsequent surveillance of the development of new polyps in the duodenal-jejunal area. We report the exceptional case of a 45-year-old man with FAP who developed two synchronic adenomatous polyps, with severe dysplasia. The first was located in the gastric antrum and the second in the proximal jejunum. Given the preoperative diagnosis of gastric neoplasm with invasion of the gastric wall (T2N0), subtotal Roux-en-Y gastrectomy and resection of the proximal jejunal segment were performed (AU)
Subject(s)
Humans , Male , Middle Aged , Intestinal Polyps/surgery , Adenomatous Polyposis Coli/complications , Choristoma/surgery , Neoplasms, Multiple Primary/surgeryABSTRACT
The management of extracolonic gastrointestinal polyps is controversial in patients with familial adenomatous polyposis (FAP). The treatment of adenomatous polyps with severe dysplasia in the stomach through wide gastric resections can hamper subsequent surveillance of the development of new polyps in the duodenal-jejunal area. We report the exceptional case of a 45-year-old man with FAP who developed two synchronic adenomatous polyps, with severe dysplasia. The first was located in the gastric antrum and the second in the proximal jejunum. Given the preoperative diagnosis of gastric neoplasm with invasion of the gastric wall (T(2)N(0)), subtotal Roux-en-Y gastrectomy and resection of the proximal jejunal segment were performed.
