ABSTRACT
The risk of second primary tumors of the respiratory and upper digestive tract developing in patients treated for head and neck cancer is well known. In these cases, the entire mucous membrane surface of the tract is affected and predisposed to metachronous or synchronous neoplasms. The mucosa of these patients is extremely susceptible to external carcinogenic stimuli. We report the results obtained in 83 patients with cancer of the oral cavity, pharynx, or larynx who experienced at least one second primary tumor. The most common site of the second primary was the lung (43.2%). We reviewed tobacco and alcohol use, treatments, and survival.
Subject(s)
Carcinoma, Squamous Cell/mortality , Esophageal Neoplasms/mortality , Laryngeal Neoplasms/mortality , Neoplasms, Second Primary/mortality , Pharyngeal Neoplasms/mortality , Adult , Aged , Aged, 80 and over , Humans , Male , Middle Aged , Neoplasms, Second Primary/diagnosis , Pharyngeal Neoplasms/diagnosis , Retrospective Studies , Survival RateABSTRACT
The evaluation and management of thyroid nodules is a common problem in medicine. In a review of 250 cases of thyroid disease seen at the 12 de Octubre Hospital (Madrid, Spain), 191 cases of solitary nodules and multinodular goiter were analyzed. The clinical findings, complementary studies, and postoperative histology were analyzed to determine the parameters most closely related to malignant thyroid processes. The overall rate of malignancy was 22.5%. Major clinical factors associated with malignancy were fixation to deep structures, cervical lymph node enlargement, and paralysis of the vocal cords. None of the complementary tests was absolutely reliable in excluding malignancy, but fine needle aspiration biopsy, in spite of its limitations, was the best diagnostic tool. Surgery is indicated if the benignity of a nodule cannot be confirmed.
Subject(s)
Thyroid Neoplasms/diagnosis , Female , Humans , Male , Middle Aged , Thyroid Neoplasms/pathology , Thyroid Neoplasms/surgeryABSTRACT
A giant juvenile nasopharyngeal fibroma in a 29-year-old male was removed by hinge maxillotomy. The diagnosis and treatment of these tumors is discussed.
Subject(s)
Fibroma/pathology , Fibroma/surgery , Maxilla/surgery , Nasopharyngeal Neoplasms/pathology , Nasopharyngeal Neoplasms/surgery , Nasopharynx/pathology , Nasopharynx/surgery , Adult , Humans , MaleABSTRACT
Amyloidosis of the upper airways is rare. The larynx is the most common site of involvement. Primary amyloidosis may be localized or generalized. We report a case of laryngeal amyloidosis in which amyloid deposits were confined to the larynx (right false vocal cord and subglottis) and successfully treated with CO2 laser.
