ABSTRACT
8 cases of contact dermatitis from toluenesulfonamide formaldehyde resin in a nail hardener are presented. Most patients had used nail lacquers containing this resin for many years without trouble, but became sensitized to the resin shortly after the introduction of this particular nail hardener. A hypothesis concerning the possible mechanism is given.
Subject(s)
Cosmetics/adverse effects , Dermatitis, Contact/etiology , Formaldehyde/analogs & derivatives , Formaldehyde/adverse effects , Sulfonamides , Toluene/analogs & derivatives , Tosyl Compounds/adverse effects , Adult , Aged , Female , Humans , Middle Aged , Nails/drug effects , Netherlands , Patch TestsABSTRACT
A controlled, randomized, double-blind trial was performed in 34 hospitalized patients with chronic leg ulcers: 37 ulcerous legs were treated with Elase solution or with saline (placebo) solution. Elase was statistically significantly better in effect on debridement (p less than 0.05) and on enhancing of granulation (p less than 0.05) than saline in patients with chronic venous stasis ulcers. In patients with complex ulcers no statistically significant difference between the two treatments was seen.
