Application of a Diagnostic Methodology of Cardiac Systems Based on the Proportions of Entropy in Normal Patients and with Different Pathologies.

INTRODUCTION: Dynamical systems theory, probability, and entropy were the substrate for the development of the diagnostic and predictive methodology of adult heart dynamics. OBJECTIVE: To apply a previously developed methodology from dynamical systems, probability, and entropy in both normal and pathological subjects. METHODS: Electrocardiographic records were selected from 30 healthy subjects and 200 with different pathologies, with a length of least 18 h. Numerical attractors from dynamical attractors and the probability of occurrence of ordered pairs of consecutive heart rates were built. A calculation of entropy and its proportions was performed and statistical analysis was conducted. RESULTS: The normal patients' heart dynamics were evaluated according to the methodology of entropy proportions, highlighting that there are differences in normal patients with different pathologies. There was maximal level of sensitivity, specificity, and diagnostic agreement. CONCLUSION: Proportional entropy constitutes a diagnostic and predictive method of heart systems, and may be useful as a tool to objectively diagnose and perform the follow-up of normal and pathological cases.

Pseudo-obstrucción lúpica Reto diagnóstico / Lupic pseudo-obstruction A diagnostic challenge

El lupus eritematoso sistémico incluye un gran espectro de manifestaciones clínicas, entre las que se encuentran las gastrointestinales que corresponden a 20% del total y éstas por lo general son consecuencia del tratamiento. Se describe el caso de una mujer joven cuya primera manifestación de una enfermedad del colágeno fue dolor abdominal, y se evidenció un proceso pseudo-obstructivo con diagnóstico definitivo de enfermedad del tejido conectivo. (Acta Med Colomb 2012; 37: 207-210).

Systemic lupus erythematosus includes a broad spectrum of clinical manifestations, including the gastrointestinal manifestations that correspond to 20% of all and which usually result as a consequence of the treatment. We describe the case of a young woman whose first manifestation of collagen disease was abdominal pain, and showed a pseudo-obstructive process with definitive diagnosis of connective tissue disease. (Acta Med Colomb 2012; 37: 207-210).

Reacciones cutáneas severas a medicamentos Dress y sulfasalazina / Severe drug-induced skin reactions DRESS and sulfasalazine

Las reacciones cutáneas severas son una de las manifestaciones adversas de los medicamentos que llegan a poner en peligro la vida. El objetivo del presente artículo es presentar el caso de una paciente con este tipo de reacciones atendido en el Hospital Universitario de La samaritana. Se trata de una mujer con síntomas cutáneos en quien se documenta reacción severa medicamentosa por sulfasalazina asociado a compromiso hepático y gastrointestinal que responde a la terapia con esteroides y la suspensión de sulfazalazina. (Acta Med Colomb 2012; 37: 83-88).

Severe skin reactions are one of the adverse drug events that can threaten life. The aim of this paper is to present the case of a female patient seen at the Hospital Universitario La Samaritana, who had this type of reaction. This is a woman with skin symptoms in whom we documented a severe drug-induced skin reaction by sulfasalazine associated to hepatic and gastrointestinal involvement that responded to steroids and the suspension of sulfasalazine. (Acta Med Colomb 2012; 37: 83-88).