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1.
Am J Hosp Palliat Care ; : 10499091241247169, 2024 Apr 25.
Article in English | MEDLINE | ID: mdl-38659417

ABSTRACT

INTRODUCTION: The Spanish National Health System has defined complexity as a set of factors of increased difficulty that require the intervention of a palliative care team. Palliative care aims to improve the quality of life of patients with chronic terminal illnesses. This study aims to describe the degree of complexity of cancer patients in palliative care, to determine which elements of complexity are most prevalent and to determine which other hospital clinical factors are associated with the level of complexity. METHODS: This study is a descriptive, observational, and cross-sectional analysis that included patients diagnosed with advanced oncological pathology undergoing palliative treatment who were admitted to the Medical Oncology ward of the Miguel Servet University Hospital between March and April 2023. RESULT: A total of 100 patients were selected for the study. According to the IDC-Pal, 68% of patients were classified as highly complex, 26% of patients were complex and only 6% of patients were classified as non-complex. The presence of pain (P < .001), nausea and vomiting (P = .027), depression (P = .033) and functional status (P = .011) were statistically independent predictors of high complexity. DISCUSSION: This study has shown that a high proportion of hospitalized palliative care cancer patients have high complexity, suggesting a good matching of healthcare resources to patient complexity. Four factors related to complexity have been identified, namely pain, nausea and vomiting, depression and a bedridden functional state. The presence of any of the 4 factors could help healthcare professionals to identify patients for early specialized palliative care.

3.
Reg Anesth Pain Med ; 2019 05 22.
Article in English | MEDLINE | ID: mdl-31118278

ABSTRACT

BACKGROUND: This double-blind, randomized trial compared dural puncture epidural analgesia (DPEA) for labor using 25-gauge and 27-gauge pencil point spinal needles. We hypothesized that both needle sizes would result in similar onset time (equivalence margin=2.5 min) and therefore designed the study as an equivalence trial. METHODS: One hundred and forty patients undergoing labor were randomized to DPEA with 25-gauge (n=70) or 27-gauge (n=70) pencil point spinal needles. After the placement of the epidural catheter, a bolus of 20 mL of bupivacaine 0.125% and fentanyl 2 µg/mL was administered to all subjects. Thereafter, patients received boluses of 12 mL of bupivacaine 0.125% every 2 hours as needed.A blinded investigator recorded the onset time (defined as the temporal interval required to achieve a pain score ≤1 on a 0-10 scale), S2 block, sensory block height (30 min after the initial bolus of local anesthetic), presence of motor block (30 min after the initial bolus of local anesthetic), number of top-up doses required during labor and incidence of postural headache. RESULTS: Out of the 140 recruited patients, 135 were retained for analysis. Compared with their 27-gauge counterparts, 25-gauge pencil point spinal needles provided a 1.6 min shorter DPEA onset (95% CI of the difference of the means: -3.2 to -0.1 min). However, there were no intergroup differences in terms of S2 block, sensory block height, motor block, number of top-up doses and incidence of postural headache. CONCLUSION: Dural puncture epidural analgesia with 25-gauge pencil point spinal needles provides a 1.6 min shorter onset time than DPEA with 27-gauge spinal needles. Although statistically significant, such a difference may not be clinically relevant. Further investigation is required to compare 25-gauge and 27-gauge spinal needles for DPEA in the setting of different local anesthetic infusion strategies. TRIAL REGISTRATION NUMBER: NCT03389945.

5.
Nefrologia ; 37 Suppl 1: 1-191, 2017 Nov.
Article in English, Spanish | MEDLINE | ID: mdl-29248052

ABSTRACT

Vascular access for haemodialysis is key in renal patients both due to its associated morbidity and mortality and due to its impact on quality of life. The process, from the creation and maintenance of vascular access to the treatment of its complications, represents a challenge when it comes to decision-making, due to the complexity of the existing disease and the diversity of the specialities involved. With a view to finding a common approach, the Spanish Multidisciplinary Group on Vascular Access (GEMAV), which includes experts from the five scientific societies involved (nephrology [S.E.N.], vascular surgery [SEACV], vascular and interventional radiology [SERAM-SERVEI], infectious diseases [SEIMC] and nephrology nursing [SEDEN]), along with the methodological support of the Cochrane Center, has updated the Guidelines on Vascular Access for Haemodialysis, published in 2005. These guidelines maintain a similar structure, in that they review the evidence without compromising the educational aspects. However, on one hand, they provide an update to methodology development following the guidelines of the GRADE system in order to translate this systematic review of evidence into recommendations that facilitate decision-making in routine clinical practice, and, on the other hand, the guidelines establish quality indicators which make it possible to monitor the quality of healthcare.


Subject(s)
Arteriovenous Shunt, Surgical/standards , Renal Dialysis/methods , Vascular Access Devices/standards , Aneurysm/etiology , Aneurysm/surgery , Angioplasty/methods , Antibiotic Prophylaxis/standards , Arteriovenous Shunt, Surgical/adverse effects , Arteriovenous Shunt, Surgical/instrumentation , Catheterization, Peripheral/adverse effects , Catheterization, Peripheral/methods , Catheterization, Peripheral/standards , Clinical Decision-Making , Constriction, Pathologic , Equipment Failure , Evidence-Based Medicine , Humans , Infection Control , Needles , Physical Examination , Rheology , Spain , Thrombosis/etiology , Thrombosis/prevention & control , Thrombosis/therapy , Vascular Access Devices/adverse effects
6.
Rev. chil. cir ; 68(4): 328-338, jul. 2016. ilus, tab
Article in Spanish | LILACS | ID: lil-788903

ABSTRACT

Los centros de cirugía ambulatoria han contribuido al progreso de esta cirugía y se caracterizan por ser eficientes, productivos, rentables y generar alta satisfacción. Construir un centro de cirugía ambulatoria requiere constituir un equipo multidisciplinario encargado de desarrollar un proyecto que evalúe la viabilidad económica, seleccione el tipo de centro a construir, determine el tamaño y el diseño del centro y defina la dotación de personal; con esta información se realiza la evaluación económica final que decide la factibilidad de construir el centro. Organizar el inicio de actividades y el funcionamiento de este servicio requiere determinar horarios, modalidad de trabajo, flujos de circulación y funciones del personal, a través de protocolos que definan, describan y coordinen todos los procesos clínicos y administrativos involucrados desde la indicación de la cirugía hasta el alta del paciente. La eficiencia del pabellón quirúrgico es determinante en el funcionamiento de un centro de cirugía ambulatoria. Varios factores contribuyen a la eficiencia de pabellón, y el más crítico de estos es el tiempo entre cirugías o tiempo de recambio de pacientes, el cual es factible de optimizar. La cirugía ambulatoria es una modalidad de trabajo quirúrgico que requiere un servicio clínico propio, adecuadamente planificado, diseñado y organizado para lograr sus objetivos y ventajas.


Ambulatory surgery centers have contributed to the progress of ambulatory surgery and they are characterized by its efficiency, productivity and to produce high satisfaction. To build an outpatient surgery center a multidisciplinary team should be responsible to develop a project that to assess the economic viability, to select the type of center, to determine the size and the design of center and to set de staffing; with this information the final economic evaluation that decide the feasibility to build the center must be performed. To organize the launch activities and the operation of this service requires determining schedules, working mode, traffic flows and staff functions through protocols that to define, to describe and to coordinate all clinic and administrative process involved from the surgery indication to the patient discharge. The operating room efficiency is determining factor in the ambulatory surgery center functioning. Several factors contribute to the operating room efficiency, the most critical of which is the time between surgical procedures o turnover time and this time is feasible to optimize. Ambulatory surgery is a mode of surgical work requiring its own clinical service properly planned, designed and organized to achieve its objectives and advantages.


Subject(s)
Operating Rooms/organization & administration , Surgicenters/organization & administration , Efficiency, Organizational , Ambulatory Surgical Procedures
7.
Ann Surg Innov Res ; 10: 2, 2016.
Article in English | MEDLINE | ID: mdl-26877764

ABSTRACT

BACKGROUND: Central venous catheterization (CVC) is a basic requirement for many medical specialties. Simulated training in CVC may allow the acquisition of this competency but few reports have established a valid methodology for learning and acquiring procedural skills for CVC. This study aims to validate the use of a tracking motion device, the imperial college surgical assessment device (ICSAD), by comparing it with validated global rating scales (GRS) to measure CVC performance in a simulated torso. METHODS: Senior year medical students, first and last year residents (PGY1, LYR), and expert anesthesiologists performed a jugular CVC assessment in a simulated model (Laerdal IV Torso). A validated GRS for objective assessment of technical skills and motion analysis by ICSAD was used. Statistical analysis was performed through Mann-Whitney and Kruskal-Wallis tests for construct validity and Spearman correlation coefficients between the ICSAD and GRS scores for concurrent validity between both. RESULTS: 32 subjects were recruited (10 medical students, 8 PGY1, 8 LYR and 8 experts). Total path length measured with ICSAD and GRS scores were significantly different between all groups, except for LYR compared to experts (p = 0.664 for GRS and p = 0.72 for ICSAD). Regarding jugular CVC procedural time, LYR and experts were faster than PGY1 and MS (p < 0.05). Spearman correlation coefficient was -0.684 (p < 0.001) between ICSAD and GRS scores. CONCLUSIONS: ICSAD is a valid tool for assessment of jugular CVC since it differentiates between expert and novice subjects, and correlates with a validated GRS for jugular CVC in a simulated torso.

8.
Eur J Clin Pharmacol ; 71(12): 1501-8, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26407689

ABSTRACT

PURPOSE: This study aims to characterize the influence of body weight and composition on the pharmacokinetics of dexmedetomidine. METHODS: Twenty obese patients and 20 non-obese patients scheduled for elective laparoscopic surgery were given dexmedetomidine infusion schemes. Venous blood samples were taken during and after dexmedetomidine administration. Population pharmacokinetic modeling was undertaken to investigate fat free mass (FFM) and normal fat mass (NFM) as size descriptors of volumes and clearances using non-linear mixed effects modeling. NFM partitions total body weight into FFM and fat mass calculated from total body weight (TBW) minus FFM. The relative influence of fat mass compared to FFM is described by the fraction of fat mass that makes fat equivalent to FFM (Ffat). RESULTS: Theory-based allometric scaling using FFM best described weight and body composition differences in clearances and volumes A negative effect of fat mass of with an exponential parameter of -0.00541/kg (95 % CI -0.0118 to -0.00246) was estimated for clearance which indicates increased fat mass is associated with impairment of clearance. CONCLUSIONS: The use of theory-based allometry with predictions of fat free mass has been able to separate the influences of weight and body composition and indicates that size-normalized clearance of dexmedetomidine is impaired in patients who are obese.


Subject(s)
Dexmedetomidine/pharmacokinetics , Hypnotics and Sedatives/pharmacokinetics , Models, Biological , Obesity/metabolism , Adolescent , Adult , Body Composition , Body Weight , Dexmedetomidine/administration & dosage , Female , Humans , Hypnotics and Sedatives/administration & dosage , Laparoscopy/methods , Male , Middle Aged , Young Adult
9.
J Clin Anesth ; 27(3): 226-32, 2015 May.
Article in English | MEDLINE | ID: mdl-25542291

ABSTRACT

STUDY OBJECTIVE: The study objective was to establish the impact of acute hypertension on morphine's requirements after laparoscopic cholecystectomy. DESIGN: The design was a randomized, simple blinded study. SETTING: The settings were operating room, postoperative recovery area, and first postoperative day. PATIENTS: There were 50 patients, American Society of Anesthesiologists I-II, aged 18-50 years, undergoing elective laparoscopic cholecystectomy with general anesthesia. INTERVENTIONS: Anesthetic management was standardized using propofol for induction, isoflurane for bispectral index (BIS) ranging between 40 and 60, and remifentanil maintained at a constant rate of 0.4 µg kg per minute throughout surgery in all patients. Once intubated, patients were randomly allocated to 1 of 2 groups: hypertensive group: systolic arterial blood pressure was maintained with phenylephrine infusion 20%-30% over baseline; control group: systolic arterial blood pressure was maintained 20%-30% below baseline. All surgical incisions were infiltrated with bupivacaine 0.5%, and every patient received ketorolac 60 mg intravenous. Patient-controlled analgesia with morphine intravenous was used for postoperative analgesia. MEASUREMENTS: Pain visual analogue scale scores, arterial blood pressure, and hyperalgesia were assessed at recovery room every 15 minutes during the first 2 postoperative hours and then at 6, 12, and 24 postoperative hours. Cumulative morphine consumption was registered at 2 and 24 postoperative hours. MAIN RESULTS: The cumulative morphine consumption in the control group was around 18 mg compared with 6 mg in the hypertensive group (P = .019). During the first 75 minutes after surgery, the control group had higher visual analogue scale score pain compared with hypertensive group (P = .005). CONCLUSIONS: The intraoperative acute generation of mild hypertension with phenylephrine reduced postoperative morphine consumption and pain scores after laparoscopic cholecystectomy.


Subject(s)
Analgesics, Opioid/administration & dosage , Hypertension/physiopathology , Morphine/administration & dosage , Pain, Postoperative/drug therapy , Adult , Female , Humans , Male , Middle Aged , Visual Analog Scale
10.
Anesth Analg ; 119(2): 302-310, 2014 Aug.
Article in English | MEDLINE | ID: mdl-24977639

ABSTRACT

BACKGROUND: Obesity is associated with important physiologic changes that can potentially affect the pharmacokinetic (PK) and pharmacodynamic (PD) profile of anesthetic drugs. We designed this study to assess the predictive performance of 5 currently available propofol PK models in morbidly obese patients and to characterize the Bispectral Index (BIS) response in this population. METHODS: Twenty obese patients (body mass index >35 kg/m), aged 20 to 60 years, scheduled for laparoscopic bariatric surgery, were studied. Anesthesia was administered using propofol by target-controlled infusion and remifentanil by manually controlled infusion. BIS data and propofol infusion schemes were recorded. Arterial blood samples to measure propofol were collected during induction, maintenance, and the first 2 postoperative hours. Median performance errors (MDPEs) and median absolute performance errors (MDAPEs) were calculated to measure model performance. A PKPD model was developed using NONMEM to characterize the propofol concentration-BIS dynamic relationship in the presence of remifentanil. RESULTS: We studied 20 obese adults (mean weight: 106 kg, range: 85-141 kg; mean age: 33.7 years, range: 21-53 years; mean body mass index: 41.4 kg/m, range: 35-52 kg/m). We obtained 294 arterial samples and analyzed 1431 measured BIS values. When total body weight (TBW) was used as input of patient weight, the Eleveld allometric model showed the best (P < 0.0001) performance with MDPE = 18.2% and MDAPE = 27.5%. The 5 tested PK models, however, showed a tendency to underestimate propofol concentrations. The use of an adjusted body weight with the Schnider and Marsh models improved the performance of both models achieving the lowest predictive errors (MDPE = <10% and MDAPE = <25%; all P < 0.0001). A 3-compartment PK model linked to a sigmoidal inhibitory Emax PD model by a first-order rate constant (ke0) adequately described the propofol concentration-BIS data. A lag time parameter of 0.44 minutes (SE = 0.04 minutes) to account for the delay in BIS response improved the fit. A simulated effect-site target of 3.2 µg/mL (SE = 0.17 µg/mL) was estimated to obtain BIS of 50, in the presence of remifentanil, for a typical patient in our study. CONCLUSIONS: The Eleveld allometric PK model proved to be superior to all other tested models using TBW. All models, however, showed a trend to underestimate propofol concentrations. The use of adjusted body weight instead of TBW with the traditional Schnider and Marsh models markedly improved their performance achieving the lowest predictive errors of all tested models. Our results suggest no relevant effect of obesity on both the time profile of BIS response and the propofol concentration-BIS relationship.


Subject(s)
Anesthetics, Intravenous/administration & dosage , Anesthetics, Intravenous/pharmacokinetics , Consciousness/drug effects , Obesity, Morbid/metabolism , Propofol/administration & dosage , Propofol/pharmacokinetics , Adult , Anesthetics, Intravenous/blood , Bariatric Surgery/methods , Body Mass Index , Body Weight , Consciousness Monitors , Drug Dosage Calculations , Drug Monitoring , Electroencephalography/instrumentation , Female , Humans , Infusions, Intravenous , Laparoscopy , Male , Middle Aged , Models, Biological , Monitoring, Intraoperative/instrumentation , Monitoring, Intraoperative/methods , Narcotic Antagonists/administration & dosage , Obesity, Morbid/blood , Obesity, Morbid/diagnosis , Obesity, Morbid/physiopathology , Obesity, Morbid/surgery , Piperidines/administration & dosage , Predictive Value of Tests , Propofol/blood , Remifentanil , Reproducibility of Results , Young Adult
11.
Ann Vasc Surg ; 27(8): 1068-73, 2013 Nov.
Article in English | MEDLINE | ID: mdl-24011812

ABSTRACT

BACKGROUND: Ultrasound screening of abdominal aortic aneurysm (AAA) has proved to reduce mortality from AAA rupture and has been implemented in several countries. Recent reports show a decreasing prevalence of AAA in Western countries. We report the results from a screening program among 65-year-old men in a defined area in the North of Spain. METHODS: We invited the 1,413 men born in 1943 and registered in the health area under our care to participate in the study. We registered their medical history and cardiovascular risk factors and we performed an abdominal ultrasound scan. We diagnosed an AAA when the infrarenal aortic diameter was ≥3 cm. We performed univariate and multivariate analysis to assess independent factors associated with the development of an AAA, using logistic regression. RESULTS: The participation rate was 70.8%. The prevalence of active smoking, hypertension, diabetes, and hypercholesterolemia was 19.6%, 52.1%, 25.7%, and 76.9%, respectively. Including 3 previously known and repaired AAAs, the total prevalence of AAA was 4.7% (n=37). The mean diameter of the AAA was 35.7±7.9 mm (range, 30-62 mm). Multivariate analysis confirmed the independent impact of active smoking (Exp[B], 3.47 [95% confidence interval {CI}: 1.67-7.22]), hypertension (Exp[B], 2.43 [95% CI: 1.08-5.45]), and peripheral arterial disease (Exp[B], 3.00 [95% CI: 1.16-7.80]) on the incidence of AAA. CONCLUSIONS: The prevalence of AAA remains high in the studied area in the North of Spain. The potential benefit of lowering smoking rates has not been observed yet. The current international recommendations of screening for 65-year-old men are still applicable in our population.


Subject(s)
Aortic Aneurysm, Abdominal/epidemiology , Aged , Aortic Aneurysm, Abdominal/diagnostic imaging , Chi-Square Distribution , Humans , Hypertension/epidemiology , Incidence , Logistic Models , Male , Mass Screening/methods , Multivariate Analysis , Odds Ratio , Patient Selection , Peripheral Arterial Disease/epidemiology , Predictive Value of Tests , Prevalence , Risk Factors , Smoking/adverse effects , Smoking/epidemiology , Spain/epidemiology , Ultrasonography
14.
Reg Anesth Pain Med ; 37(6): 633-7, 2012.
Article in English | MEDLINE | ID: mdl-23038415

ABSTRACT

BACKGROUND AND OBJECTIVES: The pharmacokinetics for levobupivacaine in transversus abdominis plane (TAP) blocks has not been previously reported. We aimed to determine the extent of the block and the effect on plasma concentrations of levobupivacaine with the addition of epinephrine. METHODS: We enrolled 11 healthy volunteers in this double-blind, 2-intervention, 2-period crossover study. The intervention periods were defined as a unilateral left TAP block with 20 mL of 0.25% levobupivacaine with (E) or without (no E) 5 µg/mL epinephrine. Subjects were randomized to E, followed by no E or no E followed by E, with 2-week washout period. Sensory dermatomal anesthesia was recorded. Blood samples were obtained for the measurement of plasma levobupivacaine levels. RESULTS: The median cranial-to-caudal spread of sensory blockade for sharp touch was T9 (interquartile range [IQR], T7-T10) to L1 (IQR, T12-L1) with epinephrine and T9 (IQR, T8-T10) to T12 (IQR, T11-L1) without epinephrine (P > 0.05). The mean maximum arterial levobupivacaine concentrations with epinephrine were 0.36 (95% bootstrap confidence interval [95% CI], 0.30-0.42) µg/mL and 0.63 (95% CI, 0.49-0.85) µg/mL without epinephrine (P = 0.014, difference in means of 0.27 [95% CI, 0.12-0.46]). The mean maximal venous levobupivacaine concentration was 0.32 (95% CI, 0.28-0.39) µg/mL and 0.49 (95% CI, 0.37-0.68) µg/mL, with and without epinephrine, respectively (P = 0.006, difference in means of 0.17 [95% CI, 0.08-0.33]). The mean duration of the blockade was 10.2 hours (95% CI, 8.5-12.5 hours) with epinephrine and 10.3 hours (95% CI, 8.7-12.4 hours) without epinephrine (P = 1.000). CONCLUSIONS: Adding epinephrine to levobupivacaine reduces its peak plasma concentration after unilateral TAP blocks, with no remarkable effects on block characteristics or duration.


Subject(s)
Anesthetics, Local/blood , Epinephrine/administration & dosage , Nerve Block/methods , Vasoconstrictor Agents/administration & dosage , Adult , Anesthetics, Local/administration & dosage , Anesthetics, Local/pharmacokinetics , Bupivacaine/administration & dosage , Bupivacaine/analogs & derivatives , Bupivacaine/blood , Bupivacaine/pharmacokinetics , Cold Temperature , Cross-Over Studies , Double-Blind Method , Drug Combinations , Humans , Levobupivacaine , Male , Prospective Studies , Touch , Ultrasonography, Interventional
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