ABSTRACT
In this article, a retrospective study was performed to describe the impact of merging two pediatric intensive care units on the overall and neurocognitive outcomes of children who required extracorporeal cardiopulmonary resuscitation (ECPR). Results from three cohorts were compared: 2008 to 2014: premerge, 2014 to 2017: initial time period postmerge, and 2018 to 2019: established merge. Survival to hospital discharge (and with good neurological outcome) was of 68% (61%), 46% (36%), and 79% (71%), respectively, for the three time periods. Merging two hospitals resulted in a nonsignificant trend toward temporary worse outcomes in pediatric patients requiring ECPR.
ABSTRACT
To evaluate the intrafamilial oropharyngeal transmission of Kingella kingae, we conducted a prospective study among pairs of siblings. We found that 55% of children who suffered from osteoarticular infections due to K. kingae, and 40% of asymptomatic carriers of K. kingae had siblings with positive oropharyngeal carriage.
Subject(s)
Kingella kingae/isolation & purification , Mouth Diseases/microbiology , Neisseriaceae Infections/microbiology , Neisseriaceae Infections/transmission , Oropharynx/microbiology , Pharyngeal Diseases/microbiology , Carrier State/epidemiology , Carrier State/microbiology , Child, Preschool , Disease Outbreaks/statistics & numerical data , Female , Humans , Infant , Kingella kingae/classification , Kingella kingae/genetics , Male , Mouth Diseases/epidemiology , Neisseriaceae Infections/epidemiology , Pharyngeal Diseases/epidemiology , Polymerase Chain Reaction , Prospective Studies , Siblings , Switzerland/epidemiologyABSTRACT
INTRODUCTION: Strains of Panton-Valentine leukocidin-producing Staphylococcus aureus producing a new pattern of disease have emerged worldwide. Infection with these bacteria typically presents as a life-threatening infection of soft tissues and bones, and may cause potentially devastating consequences. CASE PRESENTATION: We report a case of osteoarticular infection caused by Panton-Valentine leukocidin-producing Staphylococcus aureus. A 12-year-old Caucasian girl presented with acute osteomyelitis of the tibia associated with toxic shock syndrome, which was complicated by an unexpected spontaneous ankle arthrodesis. CONCLUSIONS: Osteoarticular infections due to Panton-Valentine leukocidin-producing Staphylococcus aureus appear to be severe, and are characterized by their tendency to evolve towards serious complications. This case highlights the need for early and aggressive surgical procedures in conjunction with appropriate antimicrobial therapy and regular long-term follow-up.
