ABSTRACT
Introduction: There is increasing evidence that immunohistochemical expression of p53, Ki-67, and Bcl-2 is associated with aggressive (aBCC) and less aggressive (nBCC) histological subtypes and may have a prognostic role. Aim: To investigate the clinicopathological features and immunohistochemical expressions of p53, Ki-67, and Bcl-2 in cutaneous basal cell carcinoma focusing on histological subtypes. Their roles and possible interactions in the development and progression of BCC are discussed. Material and methods: A total of 50 BCC samples from 50 patients from Western Mexico between June 2018 and June 2019 were included. Paraffin-embedded samples were immunostained with p53, Ki-67, and Bcl-2 antibodies. Semi-quantitative analysis was performed to determine the intensity and positivity of immunostained cells. Parametrical and non-parametrical tests were performed according to the sample's distribution. Results: Samples included 21 nBCC and 29 aBCC. The statistical analysis showed statistical association when grouped as non-aggressive and aggressive subtypes for p53 (p = 0.04) and Bcl-2 (p < 0.01). An inverse negative correlation was found between age and Bcl-2 expression. No statistical association was found between Ki-67 immunoreactivity and any of the other variables. Conclusions: We found that a high expression of Bcl-2 and a low expression of p53 was associated with more indolent histopathological features of BCC and therefore better outcomes. These findings suggest that examination of p53 and Bcl-2 expression in BCC patients may provide valuable prognostic information. These biomarkers may play a role in the development and progression of some cases of BCC.
ABSTRACT
Se trataron 40 pacientes con fractura diafisaria del húmero mediante osteosíntesis con placa de compresión DCP y aplicación de injerto autógeno mediante un abordaje posterior. Su edad promedio fue de 34.5 años. El 40 por ciento (16 casos) tenían lesión del nervio radial, que se reparó en el mismo tiempo operatorio. Se aplicó una férula posterior en pinza de azúcar como protección complementaria. Se obtuvo consolidación primaria en 39 de los 40 casos (97.5 por ciento) en un promedio de 12 semanas (9 a 19). Persistieron datos de lesión del nervio radial solamente en 2 de los 16 casos referidos después de un seguimiento promedio de 9 meses (6 a 18). Solamente un caso con alfojamiento del implante requirió ser reintervenido para una segunda osteosíntesis y aplicación de injerto óseo autólogo. Hubo 2 casos con necrosis superficial de la herida
Subject(s)
Humans , Male , Female , Adult , Radial Nerve/injuries , Fracture Healing , Humeral Fractures/surgery , Bone Plates , Transplantation, Autologous , Time Factors , Fractures, UnunitedABSTRACT
Se presenta la experiencia en el manejo de pacientes con acalasia primaria mediante la aplicación de estimulación eléctrica nerviosa transcutánea (TENS). Se observó una aceptable respuesta reflejada en el score de síntomas y un incremento de peso en la mayoría de los pacientes. Se considera esta modalidad terapéutica como una alternativa para el manejo de algunos pacientes con acalasia primaria
