Subject(s)
Ionophores/pharmacology , Animals , Anti-Bacterial Agents/pharmacology , Calcimycin/pharmacology , Carboxylic Acids/pharmacology , Chemical Phenomena , Chemistry , Coronary Circulation/drug effects , Dogs , Guinea Pigs , In Vitro Techniques , Lasalocid/pharmacology , Molecular Conformation , Monensin/pharmacology , Myocardial Contraction/drug effects , Nigericin/pharmacology , Structure-Activity RelationshipSubject(s)
Ionophores , Myocardial Contraction/drug effects , Amines/metabolism , Animals , Binding Sites , Cardiac Output/drug effects , Catecholamines/metabolism , Cations, Divalent , Coronary Circulation/drug effects , Dogs , Heart Rate/drug effects , Ionophores/metabolism , Lasalocid/metabolism , Lasalocid/pharmacology , Molecular Conformation , Solutions , Structure-Activity RelationshipABSTRACT
The effects of potassium canrenoate on arrhythmias induced by long-term progressive digoxin toxicity were studied in eight conscious beagle dogs. Sinus bradycardia and sinoatrial block, as well as atrioventricular (A-V) conduction disturbances, were consistently alleviated by administration of potassium canrenoate. Premature supraventricular (including junctional) and ventricular depolarizations as well as ventricular tachycardias were also suppressed. Although potassium canrenoate always terminated the digitalis-induced arrhythmias, it usually converted the rhythm to sinus arrhythmia rather than to normal sinus rhythm. Equimolar sodium canrenoate, but not potassium chloride, had similar reversal effects on arrhythmias induced by long-term digoxin intoxication. These data indicate that canrenoate, a diuretic agent with reported positive inotropic effects, may be useful in the treatment of digitalis-induced arrhythmias in man.
