ABSTRACT
OBJECTIVE: We describe the recurrence of non-viral liver disease after orthotopic liver transplantation (OLT). METHODS AND RESULTS: We studied 39 patients who received an OLT for non-viral chronic liver disease. Six (15.3%) of these patients presented disease recurrence after OLT, one following alcohol abuse, 3 presented autoimmune liver disease [2 received an OLT for primary biliary cirrhosis and recurred as autoimmune hepatitis (AIH) one patient had cryptogenic cirrhosis before OLT and recurred as AIH]. One patient showed recurrence of a non-alcoholic steatohepatitis (NASH). One patient received an OLT for cirrhosis secondary to the use of metothrexate and post OLT developed secondary biliary cirrhosis due to a choledocal stenosis in the anastomotic site. CONCLUSIONS: All patients described here displayed long term recurrence (after 11 months post OLT). The recurrence of alcoholism was 8.3% among patients transplanted for this condition. AIH was observed in 30% of cases and NASH in 20%. All three patients with autoimmune liver disease recurred with a different autoimmune disease post OLT.
Subject(s)
Liver Diseases/surgery , Liver Transplantation , Adolescent , Adult , Aged , Child , Child, Preschool , Chronic Disease , Female , Humans , Infant , Liver Diseases/diagnosis , Liver Diseases/epidemiology , Male , Middle Aged , Recurrence , Young AdultABSTRACT
Objetivo: El objetivo del presente trabajo fue analizar la frecuencia y presentación de recidiva de hepatopatías postrasplante no virales. Métodos y Resultados: Los pacientes con hepatopatías no virales que recibieron un trasplante hepático fueron 39 y de éstos, seis presentaron recidiva de la enfermedad (15.3%): uno con recaída del alcoholismo, tres con enfermedad autoinmune (dos trasplantados por cirrosis biliar primaria recurrieron con hepatitis autoinmune y uno con diagnóstico original de cirrosis hepática criptogénica presentó recurrencia de hepatitis autoinmune), uno con diagnóstico de esteatohepatitis no alcohólica tuvo recurrencia con la misma enfermedad; por último, un paciente se trasplantó por cirrosis hepática secundaria a metotrexate y postrasplante manifestó cirrosis biliar secundaria a estenosis del colédoco en el sitio de la anastomosis. Conclusiones: Todos los pacientes aquí analizados presentaron recidiva en el largo plazo (después de 11 meses postrasplante). La recidiva del alcoholismo se identificó en 8.3%, de las hepatopatías autoinmunes en 30%, y de la esteatohepatitis no alcohólica en 20% de los casos. Las tres pacientes con recidiva de hepatopatía autoinmune presentaron en el postras-plante una enfermedad diferente a la que dio origen al trasplante.
OBJECTIVE: We describe the recurrence of non-viral liver disease after orthotopic liver transplantation (OLT). METHODS AND RESULTS: We studied 39 patients who received an OLT for non-viral chronic liver disease. Six (15.3%) of these patients presented disease recurrence after OLT, one following alcohol abuse, 3 presented autoimmune liver disease [2 received an OLT for primary biliary cirrhosis and recurred as autoimmune hepatitis (AIH) one patient had cryptogenic cirrhosis before OLT and recurred as AIH]. One patient showed recurrence of a non-alcoholic steatohepatitis (NASH). One patient received an OLT for cirrhosis secondary to the use of metothrexate and post OLT developed secondary biliary cirrhosis due to a choledocal stenosis in the anastomotic site. CONCLUSIONS: All patients described here displayed long term recurrence (after 11 months post OLT). The recurrence of alcoholism was 8.3% among patients transplanted for this condition. AIH was observed in 30% of cases and NASH in 20%. All three patients with autoimmune liver disease recurred with a different autoimmune disease post OLT.
Subject(s)
Humans , Male , Female , Infant , Child, Preschool , Child , Adolescent , Young Adult , Middle Aged , Liver Diseases/surgery , Liver Transplantation , Chronic Disease , Liver Diseases/diagnosis , Liver Diseases/epidemiology , RecurrenceABSTRACT
BACKGROUND: When a child develops asthma symptoms, several changes in his/her behavior, in his/her family and in his/her social environment begin. OBJECTIVE: To identify the most frequent personality traits and psychological disturbances in asthmatic children and adolescents. MATERIAL AND METHODS: A transversal, observational and descriptive study was performed on 85 asthmatic children and adolescents ages from 5 to 18 years old that attended a questionnaire, and a graphic test on 77 of those children, which consisted on drawing two pictures. Such pictures were analyzed by a psychotherapist to determine the personality traits and the psychological disturbance present in these individuals. RESULTS: All the children answered positively at least one of the questions which detect data related to depression in the questionnaire, being the more frequent: easy anger (40%), insomnia (29%), sadness (15%), auto-aggression or suicide ideas (11%) and loss of appetite (6%). According to graphic test interpretation, 39% of children showed a depression disturbance, 29% adaptation disturbance with depression symptoms, and 12% an adaptation disturbance. In addition, we found that 2 children were victim of abuse and negligence into their families. CONCLUSION: The 100% of the evaluated asthmatic children and adolescents, showed data related to depression presence.
