1.
J Pept Sci
; 15(10): 629-33, 2009 Oct.
Article
in English
| MEDLINE
| ID: mdl-19634177
ABSTRACT
This manuscript shows that ACN can be an excellent choice for the coupling of hindered amino acids as illustrated by the coupling of Fmoc-amino acids on free amino acids anchored on a BAL synthesis. Furthermore, ACN can be a good alternative for solid-phase peptide synthesis in the absence of DMF (washings, removal of Fmoc, and coupling).
Subject(s)
Acetonitriles/chemistry , Peptides/chemical synthesis , Polyethylene Glycols/chemistry , Polystyrenes/chemistry , Amino Acids/chemistry , Fluorenes/chemistry , Solvents
2.
Bioorg Med Chem Lett
; 15(6): 1659-64, 2005 Mar 15.
Article
in English
| MEDLINE
| ID: mdl-15745817
ABSTRACT
The synthesis and evaluation as tryptase inhibitors of a library of 2,5-diketopiperazine derivatives containing guanidine or amidine functional groups is reported. Among the compounds evaluated, derivatives 6{CG4-CG8} and 6{CG4-CG9} are the most active compounds and have marked selectivity towards tryptase in front of trypsin.