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1.
J Pediatr ; 132(4): 693-8, 1998 Apr.
Article in English | MEDLINE | ID: mdl-9580772

ABSTRACT

OBJECTIVE: The objective of this study was to determine the predictors of future ambulatory blood pressure in normotensive youths with family histories of essential hypertension. STUDY DESIGN: Eighty-eight healthy youths (mean age 10.9 +/- 2.5 years; 52 blacks, 36 whites; 45 boys) were studied. During an initial visit anthropometric variables and hemodynamics were measured at rest and before, during, and after three laboratory stressors: postural change, forehead cold, and video game challenge. The subjects' ambulatory blood pressure was monitored for 24 hours as part of a follow-up evaluation an average of 2.5 years later. RESULTS: Anthropometric and demographic variables and measures of reactivity to laboratory stressors were related to future daytime and nighttime ambulatory blood pressure. CONCLUSION: These findings provide important information on the predictors of ambulatory blood pressure and underscore the importance of resting blood pressure and adiposity. These results support the guidelines of the Second Task Force, which recommend the measurement of blood pressure and adiposity in the context of ongoing health care.


Subject(s)
Blood Pressure , Hypertension/epidemiology , Blood Pressure Determination , Blood Pressure Monitoring, Ambulatory , Body Constitution , Child , Female , Humans , Longitudinal Studies , Male , Predictive Value of Tests , Prospective Studies , Risk Factors , Time Factors
2.
Bioorg Med Chem ; 5(1): 125-33, 1997 Jan.
Article in English | MEDLINE | ID: mdl-9043664

ABSTRACT

The nucleotide exchange process is one of the key activation steps regulating the ras protein. This report describes the development of potent, non-nucleotide, small organic inhibitors of the ras nucleotide exchange process. These inhibitors bind to the ras protein in a previously unidentified binding pocket, without displacing bound nucleotide. This report also describes the development and use of mass spectrometry, NMR spectroscopy and molecular modeling techniques to elucidate the structure of a drug-protein complex, and aid in designing new ras inhibitor targets.


Subject(s)
Proto-Oncogene Proteins p21(ras)/antagonists & inhibitors , Crystallography, X-Ray , Drug Design , Magnetic Resonance Spectroscopy , Proto-Oncogene Proteins p21(ras)/chemistry , Spectrometry, Mass, Fast Atom Bombardment
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