ABSTRACT
AIM: To investigate the immunoexpression and diagnostic applicability of human erythrocyte-type glucose transporter protein (GLUT-1) in oral peripheral nerve sheath tumors. MATERIAL AND METHODS: Specimens diagnosed as oral peripheral nerve sheath tumors archived in the Oral Pathology Service of Universidade Federal de Minas Gerais from 1966 to 2006 were evaluated. Thirty-four lesions were included: 15 traumatic neuromas, 11 neurofibromas, four neurilemmomas, and four malignant peripheral nerve sheath tumors (MPNST). One case of neurofibroma was associated with neurofibromatosis type I. Immunohistochemistry for S-100 and GLUT-1 was performed. S-100 was immunopositive in all lesions. RESULTS: Benign lesions were immunopositive for GLUT-1 except in two (18.2%) cases of neurofibromas. In the traumatic neuroma, the perineuriums were immunopositive for GLUT-1. In the neurofibroma, the immunoreactivity was heterogeneous. Immunopositivity was observed at levels of 54.5% in the periphery of the lesion, 9.1% in the center, and 18.2% in both. The neurilemmoma demonstrated immunopositivity in the capsule. One case (25%) of MPNST presented GLUT-1 positive stain in occasional cells distributed homogeneously in all the tumor area. CONCLUSION: GLUT-1 is a useful marker for perineurial cells and should be included in the oral peripheral nerve sheath tumors immunophenotyping thus aiding in the correct diagnosis of these lesions.
Subject(s)
Glucose Transporter Type 1/analysis , Mouth Neoplasms/pathology , Nerve Sheath Neoplasms/pathology , Biomarkers, Tumor/analysis , Cell Nucleus/pathology , Connective Tissue/pathology , Diagnosis, Differential , Humans , Immunohistochemistry , Immunophenotyping , Nerve Fibers/pathology , Neurilemmoma/pathology , Neurofibroma/pathology , Neurofibromatosis 1/pathology , Neuroma/pathology , S100 Proteins/analysisABSTRACT
The Brazilian commercial ethanol propolis extract, also formulated to ensure physical and chemical stability, was found to inhibit oral candidiasis in 12 denture-bearing patients with prosthesis stomatitis candidiasis association.
Subject(s)
Antifungal Agents/pharmacology , Candida albicans/drug effects , Candidiasis, Oral/prevention & control , Phytotherapy , Propolis/pharmacology , Adult , Aged , Animals , Antifungal Agents/administration & dosage , Antifungal Agents/therapeutic use , Bees , Brazil , Dentures , Female , Humans , Male , Microbial Sensitivity Tests , Middle Aged , Propolis/administration & dosage , Propolis/therapeutic use , Stomatitis/microbiologyABSTRACT
BACKGROUND: As the exact prevalence of oral alterations in children is still not known and the findings are controversial, other studies about this subject are necessary. METHODS: A cross-sectional survey was carried out on 1211 Brazilian children divided in two age groups: 0-4 and 5-12 years. The patients were economically classified and data of medical history were obtained from medical records. RESULTS: The frequency of children presenting alterations was 27.0%, and it was higher in older children. The most common lesions were geographic tongue, cheek biting, and melanotic macule. Candidiasis was associated with antibiotic therapy and use of pacifiers. Fissured tongue was associated with congenital anomalies, allergy; age from 5 to 12 years. There was a lack of association of patient's economic status and prevalence of oral mucosal alterations. CONCLUSIONS: The frequency of mucosal alterations in children is high and increases with age, and some of them are associated with habits and medical history of the patients.
