Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Planta Med ; 78(14): 1601-6, 2012 Sep.
Article in English | MEDLINE | ID: mdl-22814822

ABSTRACT

Plants are promising sources of new bioactive compounds. The aim of this study was to investigate the cytotoxic potential of nine plants found in Brazil. The species studied were: Annona pickelii Diels (Annonaceae), Annona salzmannii A. DC. (Annonaceae), Guatteria blepharophylla Mart. (Annonaceae), Guatteria hispida (R. E. Fr.) Erkens & Maas (Annonaceae), Hancornia speciosa Gomes (Apocynaceae), Jatropha curcas L. (Euphorbiaceae), Kielmeyera rugosa Choisy (Clusiaceae), Lippia gracilis Schauer (Verbenaceae), and Hyptis calida Mart. Ex Benth (Lamiaceae). Different types of extractions from several parts of plants resulted in 43 extracts. Their cytotoxicity was tested against HCT-8 (colon carcinoma), MDA-MB-435 (melanoma), SF-295 (glioblastoma), and HL-60 (promielocitic leukemia) human tumor cell lines, using the thiazolyl blue test (MTT) assay. The active extracts were those obtained from G. blepharophylla, G. hispida, J. curcas, K. rugosa, and L. gracilis. In addition, seven compounds isolated from the active extracts were tested; among them, ß-pinene found in G. hispida and one coumarin isolated from K. rugora showed weak cytotoxic activity. In summary, this manuscript contributes to the understanding of the potentialities of Brazilian plants as sources of new anticancer drugs.


Subject(s)
Bridged Bicyclo Compounds/pharmacology , Coumarins/pharmacology , Magnoliopsida/chemistry , Monoterpenes/pharmacology , Oils, Volatile/pharmacology , Plant Extracts/pharmacology , Annonaceae/chemistry , Antineoplastic Agents, Phytogenic , Apocynaceae/chemistry , Bicyclic Monoterpenes , Brazil , Bridged Bicyclo Compounds/chemistry , Bridged Bicyclo Compounds/isolation & purification , Cell Line, Tumor , Cell Survival , Clusiaceae/chemistry , Coumarins/chemistry , Coumarins/isolation & purification , Humans , Hyptis/chemistry , Jatropha/chemistry , Latex/chemistry , Lippia/chemistry , Monoterpenes/chemistry , Monoterpenes/isolation & purification , Oils, Volatile/chemistry , Oils, Volatile/isolation & purification , Plant Components, Aerial/chemistry , Plant Extracts/chemistry , Plant Extracts/isolation & purification , Plants, Medicinal/chemistry
SELECTION OF CITATIONS
SEARCH DETAIL
...