ABSTRACT
A sarcoidose é uma doença granulomatosa sistêmica, de etiologia ainda desconhecida. Essa doença pode acometer qualquer órgão, mas afeta principalmente pulmão e gânglios linfáticos intratorácicos. Em apenas 10% dos casos existe envolvimento extra torácico. O envolvimento articular é raro e pode-se dividir em agudo e crônico. As articulações mais afetadas na sarcoidose são as dos joelhos, punho, cotovelo e articulações das mãos e pés. Neste estudo iremos descrever um caso de um paciente com sarcoidose envolvendo a articulação sacriilíaca. O acometimento dessa região é bem raro e existem poucos casos relatados na literatura
Sarcoidosis is a systemic granulomatous disease of unknown etiology. This disease can affect any organ, but prefers lung and intra thoracic lymph nodes. In just 10% of cases there is extra thoracic involvement. Joint involvement is rare and can be divided into acute and chronic involvment. The most affected joints are the knees, wrist, elbow, and joints of the hands and feet. Herein we describe a case of a patient with sarcoidosis involving the sacriiliac joint. The involvement of this region is very rare and there are few cases reported in the literature
ABSTRACT
A sarcoidose é uma doença granulomatosa sistêmica, de etiologia ainda desconhecida. Essa doença pode acometer qualquer órgão, mas afeta principalmente pulmão e gânglios linfáticos intratorácicos. Em apenas 10% dos casos existe envolvimento extra torácico. O envolvimento articular é raro e pode-se dividir em agudo e crônico. As articulações mais afetadas na sarcoidose são as dos joelhos, punho, cotovelo e articulações das mãos e pés. Neste estudo iremos descrever um caso de um paciente com sarcoidose envolvendo a articulação sacriilíaca. O acometimento dessa região é bem raro e existem poucos casos relatados na literatura
Sarcoidosis is a systemic granulomatous disease of unknown etiology. This disease can affect any organ, but prefers lung and intra thoracic lymph nodes. In just 10% of cases there is extra thoracic involvement. Joint involvement is rare and can be divided into acute and chronic involvment. The most affected joints are the knees, wrist, elbow, and joints of the hands and feet. Herein we describe a case of a patient with sarcoidosis involving the sacriiliac joint. The involvement of this region is very rare and there are few cases reported in the literature
ABSTRACT
The objective of the study is to study the positivity of Coombs test or direct antiglobulin test (DAT) in systemic lupus erythematosus (SLE) patients and its relationship with disease's clinical and serological profile. Retrospective study of 373 SLE patients seen at single Rheumatology Unit. Epidemiological data (age, gender, age at disease onset, auto declared ethnic background and tobacco use), clinical (malar rash, photosensitivity, oral ulcers, discoid lesions, serositis, glomerulonephritis, convulsions, psychosis, hemolytic anemia, leukopenia, lymphocytopenia and arthritis), and serological profile (anti ds DNA, anti Ro/SS-A; anti La/SS-B, Anti RNP, Anti Sm, aCl (anticardiolipin) IgG, aCl Ig M, LA or lupus anticoagulant, rheumatoid factor and direct Coombs) were collected. Patients with a positive DAT were compared with the negatives. DAT was positive in 12.8% of patients and 54.3% of them had hemolytic anemia. In univariate analysis, a positive DAT was associated with hemolytic anemia (p < 0.0001), secondary antiphospholipid antibody syndrome (p = 0.02), anticardiolipin IgG (p < 0.0001), lupus anticoagulant (p = 0.05), positive VDRL (p = 0.004), anti-RNP (p < 0.0001), anti-Sm (p = 0.002), and anti-La (p = 0.02). Logistic regression revealed that hemolytic anemia, anti-RNP and anti-LA were independently associated with positive DAT. DAT was positive in 12.8% of SLE studied sample and 54.3% of them had hemolytic anemia. This test was independently associated with hemolytic anemia, anti-RNP and anti-La antibodies.
