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1.
J Ethnopharmacol ; 53(3): 175-8, 1996 Sep.
Article in English | MEDLINE | ID: mdl-8887026

ABSTRACT

The crude aqueous extract of the fruits of Caesalpinia ferrea Mart. (Leguminosae) has been investigated for possible anti-inflammatory and analgesic properties. The carrageenan induced rat hind paw edema was significantly inhibited (P < 0.05) by oral administration of 300 mg/kg of this extract. A centrally mediated analgesic effect was not observed, however, there was a dose dependent reduction in the number of total writhes induced by acetic acid.


Subject(s)
Analgesics/pharmacology , Edema/drug therapy , Plant Extracts/therapeutic use , Plants, Medicinal , Acetic Acid/administration & dosage , Acetic Acid/toxicity , Administration, Oral , Analgesics/administration & dosage , Analgesics/isolation & purification , Analgesics/therapeutic use , Animals , Carrageenan/administration & dosage , Carrageenan/toxicity , Disease Models, Animal , Dose-Response Relationship, Drug , Edema/chemically induced , Excipients/administration & dosage , Excipients/toxicity , Female , Injections, Intraperitoneal , Male , Mice , Pain/drug therapy , Plant Extracts/administration & dosage , Plant Extracts/isolation & purification , Plant Extracts/pharmacology , Rats , Rats, Wistar
2.
Rev Inst Med Trop Sao Paulo ; 35(2): 183-91, 1993.
Article in Portuguese | MEDLINE | ID: mdl-8284604

ABSTRACT

The chemoprophylactic action of the essential oil of the fruit of Pterodon pubescens Benth (Leguminosae), incorporated in different soap formulations, was studied in experimental schistosomiasis. The formulations were used locally on the tails of mice which were exposed to Schistosoma mansoni cercariae immediately, 24, 72 or 168 hours later by the method of tail immersion. Protection was evaluated 45 days after exposure when the mice were sacrificed and the worms collected by perfusion. The results showed levels of protection varying from 0.0 to 100% depending on the formulation used. A methodology that allowed the evaluation of soap protection of mice exposed to natural infection in snail infested streams on the outskirts of Belo Horizonte, MG, was also developed. Promising results were obtained in that protection of between 57.5 and 31.1% was observed in field trials when soap was applied to the animals 24 and 48 hours earlier. Preliminary studies evaluating irritation and toxicity were favorable and showed that this new prophylactic weapon could contribute to the control of schistosomiasis.


Subject(s)
Fabaceae/chemistry , Oils, Volatile/administration & dosage , Plants, Medicinal , Schistosomiasis mansoni/prevention & control , Soaps/administration & dosage , Animals , Rats , Time Factors
3.
An Acad Bras Cienc ; 56(3): 333-8, 1984 Sep.
Article in Portuguese | MEDLINE | ID: mdl-6548884

ABSTRACT

Data concerning the molluscicidal activity of 159 extracts from 84 Brazilian plants on Biomphalaria glabrata, the most important intermediate host of Schistosoma mansoni in Brazil, are presented. Seventy eight extracts (49,0%) showed activity against snails or eggs, but only twenty nine (18.2%) were active on both, snails and eggs. Extracts of two species (Mikania hirsutissima and Qualea multiflora) have shown to be lethals to adult snails at 10 ppm concentration.


Subject(s)
Biomphalaria/drug effects , Molluscacides/pharmacology , Plant Extracts/toxicity , Animals , Biomphalaria/physiology , Female , Humans , Oviposition , Schistosomiasis/prevention & control
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