Deep eutectic solvents for solid pesticide dosage forms.

Deep eutectic solvents aid the formulation of solid pesticide dosage forms for water-insoluble actives. This was demonstrated by encapsulating Amitraz powder in a low-melting matrix based on the eutectic mixture of urea (32 wt%) and 1,3-dimethylurea. Dissolution in water of melt-cast discs, containing 20 wt% active, led to the rapid release of Amitraz in a finely dispersed form. The order of magnitude reduction in particle size, after dissolution, is ascribed to the solubilization of Amitraz in the hot deep eutectic solvent and its subsequent precipitation as a separate phase on crystallization of the matrix.

Dextrin Nanocomposites as Matrices for Solid Dosage Forms.

Safe application of water-insoluble acaricides requires fast release from solid dosage systems into aquatic environments. Dextrin is a water-soluble form of partially hydrolyzed starch, which may be used as matrix material for these systems if retrogradation can be inhibited by the inclusion of nanofillers. Several glycerol-plasticized thermoplastic dextrin-based nanocomposites were prepared with a twin-screw extrusion-compounding process. The nanofillers included a layered double hydroxide (LDH), cellulose nanofibers (CNF), and stearic acid. The time-dependent retrogradation of the compounds was monitored by X-ray diffraction (XRD) and dynamic mechanical thermal analysis (DMA). XRD showed that composite samples that included stearic acid in the formulation led to the formation of an amylose-lipid complex and a stable crystallinity during aging. The most promising nanocomposite included both stearic acid and CNF. It was selected as the carrier material for the water-insoluble acaricide Amitraz. Fast release rates were observed for composites containing 5, 10, and 20% (w/w) of the pesticide. A significant reduction in the particle size of the released Amitraz powder was observed, which is ascribed to the high-temperature compounding procedure.

Mosquito repellent thermal stability, permeability and air volatility.

BACKGROUND: The effectiveness of mosquito repellents, whether applied topically on the skin or released from a wearable device, is determined by the evaporation rate. This is because a repellent has to be present in the form of a vapour in the vicinity of the exposed skin that needs protection. Therefore, gravimetric techniques were used to investigate the direct evaporation of selected liquid repellents, their permeation through polymer films, and their release from a microporous polyethylene matrix. RESULTS: Evaporation of a repellent into quiescent air is determined by its air permeability. This is a product of the vapour pressure and the diffusion coefficient, i.e. S A = P A sat D A . It was found that repellents could be ranked in terms of decreasing volatility as: ethyl anthranilate > citriodiol > dimethyl phthalate > N,N-diethyl-meta-toluamide (DEET) > decanoic acid > ethyl butylacetylaminopropionate > Icaridin. Experimental SA values, at 50 °C, ranged from 0.015 ± 0.008 mPa m2  s-1 for the least volatile repellent (Icaridin) to 0.838 ± 0.077 mPa m2  s-1 for the most volatile (ethyl anthranilate). The release rate from microporous polyethylene strands, produced by extrusion-compounding into ice water baths followed a similar ranking. These strands featured an integral skin-like membrane that covered the extruded strands and controlled the release of the repellent at a low effective rate. CONCLUSION: The high thermal and thermo-oxidative stability together with the low volatility of the mosquito repellents ethyl butylacetylaminopropionate and Icaridin make them attractive candidates for long-lasting wearable mosquito-repellent devices. Such anklets/bracelets may have utility for outdoor protection against infective mosquito bites in malaria-endemic regions. © 2019 Society of Chemical Industry.