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Acta Trop ; 157: 42-53, 2016 May.
Article in English | MEDLINE | ID: mdl-26827742

ABSTRACT

Trypanosoma cruzi has high biological and biochemical diversity and variable tissue tropism. Here we aimed to verify the kinetics of cytokine and chemokine in situ secretion in animals infected with two distinct T. cruzi strains after oral inoculation. Also, we investigated parasite migration, residence and pathological damage in stomach, heart and spleen. Our results showed that host immune response against T. cruzi infection is an intricate phenomenon that depends on the parasite strain, on the infected organ and on the time point of the infection. We believe that a wide comprehension of host immune response will potentially provide basis for the development of immunotherapeutic strategies in order to clear parasitism and minimize tissue injury. In this context, we find that KC poses as a possible tool to be used.


Subject(s)
Chagas Disease/immunology , Chagas Disease/parasitology , Chemokines/metabolism , Cytokines/metabolism , Histocompatibility Antigens Class II/metabolism , Trypanosoma cruzi/immunology , Animals , Chagas Disease/veterinary , Female , Heart/parasitology , Mice , RNA, Messenger/metabolism , Spleen/parasitology , Stomach/parasitology
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