ABSTRACT
An antigen capture ELISA was used to measure serum E. histolytica antigen and antibody levels in 23 patients with amebic liver abscess (ALA), 15 patients with intestinal amebic infections (IAI), and 20 normal controls. 16 of the 23 (70%) with ALA had antigenemia. None of those with IAI or the normal controls had E. histolytica antigen titers of greater than 1:4. All 23 of the patients with ALA had positive antibody titers. Three (20%) with IAI and none of the normal controls had E. histolytica antibody titers greater than 1:100. Antigenemia cleared in all but one of the 23 patients within two months of initiating successful chemotherapy. Antibody titers were much slower to diminish. Measuring E. histolytica antigens in the sera of patients with ALA by increasing the diagnostic specificity may have some diagnostic advantage over measuring only the antibody levels. In addition, serial measurements of antigenemia are useful in monitoring result following chemotherapy.
Subject(s)
Antibodies, Protozoan/blood , Antigens, Protozoan/blood , Entamoeba histolytica/immunology , Liver Abscess, Amebic/diagnosis , Animals , Enzyme-Linked Immunosorbent Assay , Humans , Liver Abscess, Amebic/drug therapy , Predictive Value of TestsABSTRACT
Clinical characteristics of 52 patients with amebic liver abscess are reported. Forty-two percent had an acute illness, usually with high fever, vomiting, sweating, pain in the abdominal right upper quadrant, and leukocytosis. The other 58% had a more chronic illness, usually with a dull ache in the right upper abdomen, weight loss, fatigue, moderate or low-grade pyrexia, and anemia. Hepatomegaly and hepatic tenderness were present in all patients; fever occurred in 75%. The diagnosis was strongly suggested by amebic antibodies in high titer and hepatic abscesses demonstrated by sonography. Mean abscess diameter was 9.2 cm; 37% were larger than 10 cm. Most abscesses were solitary (81%), in the right lobe (73%), rounded or oval (78%), cystic (57%), and had a well-defined wall (53%). However, 43% were initially solid or heterogeneous. The latter lesions always developed a cystic pattern when ultrasonography was repeated. The diagnosis was confirmed by a good clinical response to metronidazole in 50 patients. Complications included right-sided pleural effusions or empyema (13%), ascites (13%), and jaundice (13%). Drainage of large abscesses was performed in four patients. All 52 patients survived and were cured.
Subject(s)
Liver Abscess, Amebic/diagnosis , Ultrasonography , Adolescent , Adult , Aged , Child , Child, Preschool , Egypt , Female , Humans , Liver/pathology , Liver Abscess, Amebic/drug therapy , Male , Metronidazole/therapeutic use , Middle AgedABSTRACT
Hepatic ultrasonography not only can be used to detect amebic liver abscess, but can follow its resolution. Twenty-five patients with 32 abscesses had hepatic sonography performed repeatedly. Sonography clearly demonstrated abscesses of 1-22 cm; 19 patients (76%) had abscesses only in the right lobe of the liver, and 22 (88%) had solitary abscesses. Resolution time ranged from 2 months for the smallest abscess to 20 months for the largest. Four abscesses initially had a heterogenous partially solidified pattern. All abscesses healed completely, leaving normal hepatic sonographic patterns.
Subject(s)
Liver Abscess, Amebic/diagnosis , Ultrasonography , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Liver Abscess, Amebic/drug therapy , Liver Abscess, Amebic/physiopathology , Male , Metronidazole/therapeutic use , Middle Aged , Time FactorsSubject(s)
Liver Diseases, Parasitic , Schistosomiasis , Acute Disease , Animals , Central Nervous System/pathology , Child , Chronic Disease , Colon/pathology , Diagnosis, Differential , Hepatitis, Viral, Human/complications , Humans , Hypertension, Portal/drug therapy , Hypertension, Portal/surgery , Hypertension, Portal/therapy , Kidney/pathology , Liver/diagnostic imaging , Liver/pathology , Liver Diseases, Parasitic/complications , Liver Diseases, Parasitic/immunology , Liver Diseases, Parasitic/pathology , Liver Diseases, Parasitic/therapy , Mice , Niridazole/therapeutic use , Oxamniquine/therapeutic use , Praziquantel/therapeutic use , Radiography , Salmonella Infections/complications , Schistosomiasis/complications , Schistosomiasis/immunology , Schistosomiasis/pathology , Schistosomiasis/therapy , Schistosomicides/therapeutic use , Sclerosing Solutions/therapeutic useABSTRACT
One hundred patients with bleeding oesophageal varices were randomized into two treatment groups after resuscitation. One group was managed by tamponade only (group 1); the other group (group 2) was treated by endoscopic injection of oesophageal varices. The patients in group 2 were further subdivided into 25 patients (group 2a), who had tamponade applied immediately after sclerotherapy, and 25 patients (group 2b), who had sclerotherapy without subsequent tamponade. Injection of varices controlled the acute bleeding episode more effectively than tamponade (74 per cent in group 2 v. 42 per cent in group 1). There was no significant difference in the overall mortality rate of the two groups, but group 2 had a significantly higher proportion of Child's grade C patients (38/50 v. 29/50 = 76 v. 58 per cent). If only Child's grade C patients are considered, 16 out of 29 (55 per cent) died in group 1, whereas only 12 out of 38 (32 per cent) died in group 2 (P less than 0.05). Tamponade applied after sclerotherapy had no demonstrable effect on the outcome of sclerotherapy. The long term follow-up of patients (maximum 4 years) showed that recurrence of bleeding was less in the sclerotherapy group (8.1 per cent) than in the tamponade only group (27.6 per cent; P less than 0.05).
