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1.
Planta Med ; 63(5): 479-82, 1997 Oct.
Article in English | MEDLINE | ID: mdl-9342957

ABSTRACT

Phytochemical analyses of Geigeria alata (Benth. & Hook.) and Francoeuria crispa (Forssk., Cas.) (Asteraceae) essential oils were performed. G. alata oil showed moderate in vitro cytotoxicity (IC50, micrograms/ml against tumor cells; P388: 2.0, A-549: 2.5 and HT-29: 5.0), and also showed weak anti-HIV activity. S-Carvotanacetone, the major component of F. crispa oil (93.0%), was isolated and its structure was elucidated by 2D-NMR analysis.


Subject(s)
Anti-HIV Agents/isolation & purification , Antineoplastic Agents, Phytogenic/isolation & purification , HIV/physiology , Oils, Volatile/analysis , Plants, Medicinal , Plants, Toxic , Animals , Anti-HIV Agents/chemistry , Anti-HIV Agents/pharmacology , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/toxicity , Cell Survival/drug effects , Gas Chromatography-Mass Spectrometry , HIV/drug effects , Humans , Leukemia P388 , Mice , Tumor Cells, Cultured , Virus Replication/drug effects
3.
Experientia ; 35(9): 1131-2, 1979 Sep 15.
Article in English | MEDLINE | ID: mdl-488253

ABSTRACT

Total synthesis of cannabispiran (1) was accomplished by a biomimetic-type cyclization of the bibenzyl 2, using K3Fe(CN)6 or MoCl4.


Subject(s)
Estradiol Congeners , Indans/chemical synthesis , Indenes/chemical synthesis , Spiro Compounds/chemical synthesis , Magnetic Resonance Spectroscopy , Methods , Structure-Activity Relationship
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