ABSTRACT
Salivary gland haemangioma is more common in the parotid than in any other salivary gland. Parotid haemangioma is considered to be the most common salivary gland tumour in infants, but is also occasionally encountered in adults. A case of cavernous haemangioma affecting the submandibular salivary gland in an adult woman is presented. The striking histological feature is the presence of numerous vascular channels assuming a periductal arrangement.
Subject(s)
Hemangioma, Cavernous/pathology , Submandibular Gland Neoplasms/pathology , Adult , Female , Hemangioma, Cavernous/complications , Humans , Neck , Submandibular Gland Neoplasms/complications , Tuberculosis, Lymph Node/complicationsABSTRACT
Fetuses of pregnant mice exposed to whole body gamma-irradiation (400 rads) on the 12th gestational day were compared with control fetuses to assess the effect of radiation on palatogenesis. Experimental and control groups were sacrificed on day 18 of gestation. The fetuses were removed via laparotomy and counted to determine the litter size. Animals were decapitated and the maximum head height, width, and circumference recorded. For light microscopic examination of palatogenesis, heads were fixed in Bouin's solution and prepared for paraffin sectioning and staining with hematoxylin and eosin. A significant reduction in litter size (p < .0025) and head measurements (p < .005) of irradiated fetuses was observed when compared to those of the control group. Histologic examination of serial coronal sections demonstrated that 100% of the experimental fetuses had palatal clefts. It was concluded that gamma-rays have adverse effects on the litter size, head measurements, and palatal closure of mouse fetuses.
Subject(s)
Abnormalities, Radiation-Induced , Cleft Palate/etiology , Gamma Rays , Palate/radiation effects , Animals , Cleft Palate/embryology , Female , Fetus/radiation effects , Gestational Age , Head/embryology , Head/radiation effects , Litter Size/radiation effects , Mice , Mice, Inbred Strains , Palate/embryology , PregnancyABSTRACT
Development of the tongue in murine fetuses, in which the dams were exposed to whole body gamma-irradiation (400 rads) on the 12th day postcoitum, was studied and compared with unirradiated controls. Experimental and control groups were killed on day 18 of gestation and the fetuses were removed via laparotomy. The fetal heads were excised, fixed in Bouin's solution, prepared for paraffin sectioning, and stained with hematoxylin and eosin for light microscopic examination. Histologic examination of serial coronal sections demonstrated that all of the experimental fetuses possessed malformed, poorly developed tongues, when compared to those of the control group. It was concluded that gamma-irradiation has an adverse effect on tongue development in mouse fetuses.
Subject(s)
Embryonic and Fetal Development/radiation effects , Gamma Rays , Prenatal Exposure Delayed Effects , Tongue/embryology , Tongue/radiation effects , Animals , Female , Male , Mice , Mice, Inbred Strains , PregnancyABSTRACT
Fetuses of pregnant albino mouse exposed to 400 rad of gamma-irradiation, on the 12th gestational day, were compared with unirradiated fetuses to asses the radiation effect on developing incisors. Pregnant animals were sacrificed on day 18 post coitum, and their fetuses were decapitated. Heads were routinely prepared, frontally sectioned, and stained with hematoxylin and eosin. Histologic examination demonstrated that the development of the maxillary and mandibular incisors was retarded in all the experimental fetuses and were in early bell stage, whereas those of the control animals were elaborated their matrices. It was concluded that gamma-irradiation interferes with cytodifferentiation of the enamel organ and dental papilla and subsequently inhibits normal odontogenesis.
