ABSTRACT
Hypertrophic burn scars pose a challenge for burn survivors and providers. In many cases, they can severely limit a burn survivor's level of function, including work and recreational activities. A widespread modality of prevention and treatment of hypertrophic scarring is the utilization of pressure garment therapy (PGT). Despite the magnitude of the problem of hypertrophic scarring and the ubiquitous use of pressure garments as therapy, strong clinical evidence of the efficacy of PGT in the literature is lacking. Some of the challenges facing measurement of efficacy of PGT on hypertrophic scarring are lack of clear definitions for degree of hypertrophic scarring, inability to quantify pressure applied to scars, patient noncompliance to strict PGT time schedules, and inability to conduct randomized controlled trials comparing PGT to no therapy for ethical reasons since PGT is considered a standard of care. In this review, we attempt to summarize and analyze evidence-based literature on PGT and its efficacy in burn hypertrophic scars published in English language in the past 15 years.
Les cicatrices de brûlures hypertrophiques représentent un défi pour les survivants de brûlures et les fournisseurs. Dans de nombreux cas, ils peuvent gravement limiter le niveau de fonction d'un survivant de brûlure, y compris au travail et pendant les loisirs. Une modalité généralisée de la prévention et le traitement des cicatrices hypertrophiques est l'utilisation de la thérapie de vêtement de compression (TVC). Malgré l'ampleur du problème des cicatrices hypertrophiques et l'utilisation omniprésente de vêtements compressifs en tant que thérapie, dans la littérature il n'y a pas de preuves cliniques solides de l'efficacité de la TVC. Quelques-uns des défis auxquels fait face la mesure de l'efficacité de ce traitement sur les cicatrices hypertrophiques sont: le manque de définitions claires pour degré de cicatrisation hypertrophique, l'incapacité de quantifier la pression appliquée sur les cicatrices, la non-conformité des patients en ce qui concerne les horaires strictes du traitement, et l'incapacité de mener des essais comparatifs randomisés comparant cette thérapie à aucun traitement pour des raisons éthiques car la TVC est considérée comme une norme de soins. Dans cette revue, nous tentons de résumer et d'analyser la littérature fondée sur des preuves de la TVC et son efficacité dans les cicatrices hypertrophiques des brûlures publiés en langue anglaise au cours des 15 dernières années.
ABSTRACT
This paper is a comprehensive review of hand burn injuries. The different classifications of thermal burns, out- and inpatient care, indications for escharotomies as well as surgical management, skin substitutes, and paediatric hand burns are thoroughly reviewed.
ABSTRACT
The concentration of 10 elements has been determined in fingernail and hair of four groups representing normal and hepatosplenic (bilharzial) subjects. Samples were collected from rural inhabitants to the east of Alexandria City and irradiated with thermal neutrons from a Triga Mark III Reactor, for 10 minutes. Measurements were made using HPGe detector, ADC and PDP 11/34. The analysis were performed using the RAYGUNprogram. The results showed an increase in the concentration of Al, Cl and I in both fingernail and hair of bilharzial patients than normal while Mg, Ca, K, Mn, Cu, and Sr decreased. Most of the elements showed a higher concentration in fingernail than in hair.
Subject(s)
Hair/chemistry , Nails/chemistry , Schistosomiasis mansoni/metabolism , Trace Elements/analysis , Adult , Egypt , Humans , Male , Neutron Activation AnalysisABSTRACT
The effect of neutron doses from a D-T compact neutron generator on the liver cells of adult male and female albino Swiss mice was investigated. Fast neutrons (14.5 MeV) were delivered to the whole body in a single dose or in two, four, six or eight equal doses separated by 3-day intervals. The lowest dose, 100 rem, was given for an exposure time of 6 hours and was then steadily raised to 912 rem for an exposure time of 48 hours. During exposure the neutron flux was controlled by the activation foil technique. Animals were killed for testing after each irradiation. Histological examination of the hepatocytes in the light microscope showed marked degenerative changes only after the longer irradiation periods (24, 36 and 48 h). Electron microscopy showed cytological (cytoplasmic and nuclear) changes in the hepatocytes after only 12 hours' irradiation. Densitometric scans of electron micrographs of control and 12 h-irradiated livers indicated that the control hepatocyte interphase nucleus contains approximately 72% heterochromatin, while the irradiated nucleus contains only 64% heterochromatin.
