ABSTRACT
This study evaluates the effect of DDB on normal and chemically-injured liver. When given to normal rats DDB had no significant effect on liver enzymes, but in chemically-injured rats there was a significant decrease in the elevated levels of liver enzymes. DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically-injured liver. The histopathology examinations showed a slight improvement with DDB administration. DDB has a beneficial effect on liver enzymes and possesses significant antioxidant properties in normal and chemically-injured liver, and may therefore be clinically useful in treating chronic viral hepatitis B in humans.
Subject(s)
Adjuvants, Immunologic/therapeutic use , Cytochrome P-450 Enzyme Inhibitors , Dioxoles/therapeutic use , Disease Models, Animal , Liver Diseases/drug therapy , Liver/drug effects , Adjuvants, Immunologic/pharmacology , Administration, Oral , Animals , Antioxidants/pharmacology , Antioxidants/therapeutic use , Carbon Tetrachloride , Chemical and Drug Induced Liver Injury , Dioxoles/pharmacology , Drug Evaluation, Preclinical , Drugs, Chinese Herbal/pharmacology , Drugs, Chinese Herbal/therapeutic use , Glucosephosphate Dehydrogenase/drug effects , Glucosephosphate Dehydrogenase/metabolism , Glutathione/drug effects , Glutathione/metabolism , Glutathione Peroxidase/drug effects , Glutathione Peroxidase/metabolism , Glutathione Reductase/drug effects , Glutathione Reductase/metabolism , Liver/metabolism , Liver/ultrastructure , Liver Diseases/metabolism , Liver Diseases/pathology , Liver Function Tests , Male , Malondialdehyde/metabolism , Rats , Time FactorsABSTRACT
This study evaluates the effect of DDB on normal and chemically-injured liver. When given to normal rats DDB had no significant effect on liver enzymes, but in chemically-injured rats there was a significant decrease in the elevated levels of liver enzymes. DDB produced a significant increase in reduced glutathione, glutathione peroxidase and glutathione reductase, and a significant decrease in malondialdehyde and glucose-6-phosphate dehydrogenase in both normal and chemically-injured liver. The histopathology examinations showed a slight improvement with DDB administration. DDB has a beneficial effect on liver enzymes and possesses significant antioxidant properties in normal and chemically-injured liver, and may therefore be clinically useful in treating chronic viral hepatitis B in humans