ABSTRACT
This study includes 62 cases of spontaneous abortions and 75 cross matched non pregnant multiparous women as controls. Micro-ELISA test was done to measure Toxoplasma IgM & IgG antibodies. Out of 62 aborting women, 26 gave positive anti-Toxoplasma IgG antibodies, more than 45 Eu/ml and 28 gave positive anti-Toxoplasma IgM antibodies, more than 40 Eu/ml without statistical significant difference. There was a significant difference between aborting women and the controls as regards IgG & IgM antibodies. IgG antibodies, showed statistical significant difference between those with no history of abortions or I-2 abortions versus those with 3 or more abortions. The infection was more among aborting women in rural than urban areas whom suffered poor hygienic measures and awareness about the mode of transmission of Toxoplasma infection. The results were discussed.
Subject(s)
Abortion, Spontaneous/immunology , Antibodies, Protozoan/blood , Immunoglobulin G/blood , Immunoglobulin M/blood , Pregnancy/immunology , Toxoplasma/immunology , Abortion, Spontaneous/blood , Animals , Case-Control Studies , Congenital Abnormalities , Enzyme-Linked Immunosorbent Assay/methods , Female , Fetal Death , Humans , Infant, Newborn , Pregnancy/blood , Reference Values , Rural Population , Socioeconomic Factors , Urban PopulationABSTRACT
Circulating S. mansoni soluble antigens (CSA) and antibodies (CAB) were investigated in sera of 32 S. mansoni-infected pregnant mothers, their 32 newborns and 26 non-pregnant infected women. CSA levels in pregnant mothers and their newborns were significantly higher than in the 3rd group. Also, a significant positive correlation was detected between the CSA levels in sera from infected mothers and the cord blood of their newborns proving the transplacental transfer of these antigens. On the other hand, CAB levels were significantly higher in the 3rd group than in the mothers and their newborns and this could be explained by the immune complexes formation. No schistosome eggs or worms were detected in placentas and the possibility of congenital schistosomiasis was eliminated.
