ABSTRACT
To explore the status of irrational drug use in a hospital between the pre-intervention (2018 to 2019) and post-intervention (2020 to 2021) in Beijing and evaluate the effects of relevant interventions. Prescriptions were evaluated manually with reference to the management rules of the china prescription administrative policy, standard management of hospital prescription comments, standards for prescription examination in medical institutions, regulations on pharmaceutical administration in medical institutions and the administrative measures for the clinical application of antibiotics. There were 5,584 irrational outpatient electronic prescriptions, with 1,681, 1,554, 1,234 and 1,115 made annually from 2018 to 2021, respectively. Among the all irrational prescriptions, high proportions were filled by patients aged 15 to 34 years (55.62%), female patients (50.90%), patients with complications (77.42%) or chronic diseases (65.45%). The top-three types of irrational electronic prescriptions were incomplete prescription postscript (24.05%), excessive dosage (19.75%) and inappropriate medication frequency (16.42%). Among all the physicians who prescribed, the most common was physicians aged from 25 to 30 years (45.61%) and with a junior title (64.83%). Although irrational drug use interventions could significantly improve the prescribing of irrational electronic prescriptions, the situation of irrational prescribing still exists. Related interventions should be taken in future clinical work.
Subject(s)
Drug Prescriptions , Physicians , Humans , Female , Outpatients , Hospitals , Anti-Bacterial Agents/therapeutic use , Practice Patterns, Physicians'ABSTRACT
Objective To discuss the effects of different exercise frequency and diet guidance for fat loss on obese patients, and to develop a safe and effective multidisciplinary intervention program for obese patients. Methods A total of 140 members of Ningbo Slimming Club were recruited, with the age between 18-60 years, body mass index (BMI) greater than 28 kg/m2, and they were randomly assigned to low frequency group and high frequency group. In low frequency group, the intervention was complete 100 minutes aerobic exercise and 3 times a week. In high frequency group, the intervention was complete 50 minutes of aerobic exercise and 6 times a week. Each group followed the same diet weight loss program. By comparing each index before and after the intervention, the effect of fat loss was evaluated. Results After intervention, systolic blood pressure, diastolic blood pressure, body weight, BMI, waist circumference, body fat percentage, triglyceride, low density lipoprotein and total cholesterol in two groups were decreased, and high density lipoprotein were increased (P<0.05) . Compared between the low frequency and high frequency exercise group, there were no significant difference for the systolic blood pressure, diastolic blood pressure, body weight, waist circumference, BMI, triglyceride, high density lipoprotein, low density lipoprotein and total cholesterol levels (P>0.05), but body fat percentage in low frequency exercise group decreased significantly (P< 0.05) . Conclusion Diet intervention combined with exercise has a significant effect of fat loss on obese patients. Based on the same weekly aerobic exercise time, obese patients with low frequency of exercise had better fat loss than obese patients with high frequency of exercise.
ABSTRACT
To approach the effect of CCAAT/enhancer binding proteins (C/EBPs) on un-terminal differentiation of HL-60 cells after treatment with Arsenic Trioxide ( As_2O_3) . Methods The changes of cell morphology were observed by Wright staining, the alteration in the cell proliferation was determined by WST1 experiment and the NBT reduction assay was used to detect the differentiation condition of cells, determination and analysis cell cycle. The expressions of C/EBP? and C/EBP? mRNA in HL-60 cells exposed to ATRA and As_2O_3 were assayed by semi-quantitative RT-PCR. Results It was found that ATRA could up- regulate the mRNA expression of C/EBP? obviously, but down-regulate the mRNA expression of C/EBP?. As_2O_3 could up-regulate the mRNA expression of C/EBP? lightly, down-regulate the expression of C/EBP?. Conclusion Both of ATRA and As_2O_3 can down-regulate the mRNA expression of C/EBP?,but there is no significant difference between these two groups,ATRA and As2O3 can up- regulate the mRNA expression of C/EBP?, with significant differences (P