[Cerebrovascular and renal effects of cerebrolysin and dependence on salt intake]. / Tserebrovaskuliarnye i renal'nye éffekty tserebrolizina v zavisimosti ot solevogo rezhima.

Experiments on rats with occluded common carotid arteries showed that an excess sodium chloride consumption increased the loss of test animals as a result of the maximum decrease in the local cerebral blood flow and sharply pronounced brain swelling. The sodium chloride substitute hyposol (giposol) reduced the extent of cerebral ischemia and brain swelling effect and increased the renal perfusion and diuresis levels. In the test animals receiving a high-Na diet, the efficacy of cerebrolysine was less pronounced. In contrast, hyposol increased the antiischemic, saluretic and antiswelling effects of cerebrolysine under the carotid artery occlusion.

[The mineral dietary composition affects glucose metabolism and modulates insulin effect in intact rats]. / Vliianie mineral'nogo sostava ratsiona na obmen gliukozy i moduliatsiia deistviia insulina u intaktnykh krys.

The experiments on intact rats showed that an excess sodium chloride consumption and the use of giposol (NaCl substitute) produce a hypoglycemic effect. Giposol increases, whereas NaCl decreases, the glucose tolerance. Giposol activates hexokinase and glucose-6-phosphate dehydrogenase (the key enzymes of the glucose metabolism in tissues) and reduces the effect of insulin. Both giposol and NaCl increase the level of glucose absorption in small intestine. The gastric motility is activated by NaCl and not affected by giposol.

[The efficacy of different salt diets and the modulation of the protective action of cerebrolysin in an experimental disturbance of the cerebral circulation]. / Effektivnost' razlichnykh solevykh diet i moduliatsiia zashchitnogo deistviia tserebrolizina pri éksperimental'nom narushenii mozgovogo krovoobrashcheniia.

Experiments on rats showed that long-term excess sodium chloride feeding increased the loss of animals as a result of the common carotid artery ligation. The effect is related to maximum decrease in the local cerebral blood flow and sharply pronounced brain swelling. The sodium chloride substitute giposol reduced the extent of cerebral ischemia and produced antiswelling effect. On the background of the hyper-sodium-chloride diet, the protective action of cerebrolysine was less pronounced as manifested by decreasing survival of the test animals. In contrast, the administration of giposol increased the efficacy of cerebrolysine with respect to the carotid artery occlusion.