ABSTRACT
With the help of tests on 10 big biological objects (sheep) was studied a modern model of severe lateral damage (6 mm diameter) of femoral artery. Within 45 seconds blood loss was 432.5 +/- 258.2 ml. The usage of domestic local hemostatic agent--"Gemostop" based on zeolite and "Gemofleks" based on chitosan. The total three-hour mortality was 50%. Primary hemostasis was recorded only in 20% of biological objects, the final hemostasis in 60%. Thus, the model of standard 6-mm lateral damage of femoral artery with a free primary hemmorage during 45 seconds should be considered as. optimal for evaluating the effectiveness of modern hemostatic agents.
Subject(s)
Femoral Artery/injuries , Hemorrhage/prevention & control , Hemostatic Techniques , Hemostatics/therapeutic use , Sheep , Wounds, Penetrating/complications , Administration, Topical , Animals , Disease Models, Animal , Female , Hemostatics/administration & dosage , Treatment OutcomeABSTRACT
Today self-expanding polymers are considered as the most promising as means for intracavitary hemostasis in case of continuing bleeding after trauma. Testing of domestic open-cell polyurethane foam composition "Locus" was carried out on the developed experimental model simulating liver trauma of V degree. After damaging 6 experimental rabbits were injected intraperitoneally with 80 ml of the composition. 5 experimental rabbits were included into to control group (haemostatic agent was not given). Estimated blood loss was 111-124 ml. The two-hour survival rate didn't differ significantly: 3 animals survived in the experimental group; 2 animal survived in the control. Despite the 3-4-fold widening of the foam, due to open cells it absorbed 72.6 +/- 8.3 g of blood. Thus, open-cell polyurethane foam intraperitoneal administration of the composition didn't provide a temporary intra-abdominal hemostasis in liver. In order to enhance the hemostatic effect it requires changing the formulation of the polyurethane composition. For a more accurate assessment of the results it is neccessary to perform additional researches on larger animals.
Subject(s)
Abdominal Injuries/therapy , Hemorrhage/therapy , Hemostatic Techniques , Liver/injuries , Polyurethanes/pharmacology , Animals , Disease Models, Animal , Female , Hemorrhage/etiology , Male , Rabbits , Trauma Severity Indices , Treatment OutcomeABSTRACT
Authors came to conclusion that the constant monitoring of servicemen's health status allows the commanding officer to receive detailed information about combat effectiveness. In case of battle injury or trauma the information used by the medical service will be the base for early health care delivery and organization of evacuation. The information about health status of injured may be used as a base for diagnosis at all stages of evacuation. Authors came to conclusion that individual monitoring of health status will help to further health care delivery system and first stages of medical evacuation.
Subject(s)
Delivery of Health Care , Military Medicine , Military Personnel , Monitoring, Physiologic , Warfare , Delivery of Health Care/methods , Delivery of Health Care/organization & administration , Delivery of Health Care/standards , Delivery of Health Care/trends , Humans , Military Medicine/methods , Military Medicine/organization & administration , Military Medicine/standards , Military Medicine/trends , Monitoring, Physiologic/methods , Monitoring, Physiologic/standards , Monitoring, Physiologic/trendsABSTRACT
Ongoing intra-abdominal bleeding is the main life-threatening sequence of blunt abdominal trauma. The use of local hemostatic agents allows achieving fast and reliable hemorrhage control in case of parenchymatous organs injury. We investigated the efficacy of a dressing "Celox Gauze" in an experimental model of grade IV liver injury in large animals in the setting of coagulopathy. We used the following experimental model: 30-35% of blood volume was withdrawn followed by severe liver injury and hemostatic agent application. Laboratory tests were controlled in three endpoints. Hemostasis was evaluated in 2 days. "Celox Gauze" was effective for hemorrhage control in 100% of cases. All animals survived until the end of the experiment. Perihepatic packing with "Celox Gauze" applied is more effective to control hemorrhage than packing only. It has been noted lower volume of blood loss, lower decrease of red blood cells in animals of "Celox Gauze" group. We noted no adverse effects. Histological analysis showed the absence of any significant local hepatic damage. In whole the local hemostatic agent "Celox Gauze" has been shown highly effective in the model of parenchymatous bleeding. Additional studies with more number of animals are warranted to confirm our results.
