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Interleukin-37 Protects Stem Cell-Based Cartilage Formation in an Inflammatory Osteoarthritis-Like Microenvironment.
van Geffen, Ellen Wilhelmina; van Caam, Arjan Petrus Maria; Vitters, Elly Louise; van Beuningen, Henk Maria; van de Loo, Fons Adrianus; van Lent, Peter Leonardus Everardus Maria; Koenders, Marije Ingrid; van der Kraan, Peter Mario.
Tissue Eng Part A ; 25(15-16): 1155-1166, 2019 08.
Article in English | MEDLINE | ID: mdl-30526407

ABSTRACT

IMPACT STATEMENT: Catabolic factors present in a damaged joint inhibit chondrogenic differentiation of mesenchymal stem cells, thereby reducing the chance for successful cartilage formation. By improving stem cell-based cartilage repair with interleukin-37 (IL37), we might be able to inhibit the worsening progression of focal cartilage defects and prevent further development of joint diseases such as osteoarthritis. This will avoid chronic pain and impaired joint mobility for patients and reduce costs for society.


Subject(s)
Cellular Microenvironment , Chondrogenesis , Cytoprotection , Inflammation/pathology , Interleukin-1/metabolism , Mesenchymal Stem Cells/metabolism , Osteoarthritis/pathology , Cartilage/metabolism , Cartilage/pathology , Cellular Microenvironment/drug effects , Cellular Microenvironment/genetics , Chondrogenesis/drug effects , Chondrogenesis/genetics , Collagen/metabolism , Culture Media, Conditioned/pharmacology , Gene Expression Regulation/drug effects , Humans , Inflammation/genetics , Inflammation Mediators/metabolism , Interleukin-1beta/metabolism , Mesenchymal Stem Cells/drug effects , Osteoarthritis/genetics , Proteolysis/drug effects
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