Subject(s)
Colonic Neoplasms/diagnosis , Colonoscopy/methods , Hemangioma, Cavernous/diagnosis , Intestinal Polyps/diagnosis , Abdominal Pain/diagnosis , Abdominal Pain/etiology , Adult , Biopsy, Needle , Colonic Neoplasms/pathology , Colonic Neoplasms/surgery , Endoscopy/methods , Follow-Up Studies , Hemangioma, Cavernous/pathology , Hemangioma, Cavernous/surgery , Humans , Immunohistochemistry , Intestinal Polyps/pathology , Intestinal Polyps/surgery , Male , Rare Diseases , Risk Assessment , Treatment OutcomeSubject(s)
Capsule Endoscopy/methods , Jejunal Neoplasms/diagnosis , Lymphoma, Follicular/diagnosis , Biopsy, Needle , Catheterization/methods , Chronic Disease , Colonoscopy/methods , Diarrhea/diagnosis , Diarrhea/etiology , Duodenoscopy/methods , Endoscopy, Gastrointestinal/methods , Female , Humans , Immunohistochemistry , Intestinal Mucosa/pathology , Jejunal Neoplasms/pathology , Lymphoma, Follicular/pathology , Middle Aged , Sensitivity and SpecificityABSTRACT
BACKGROUND: The aim of our study was to investigate the prevalence of Crohn's disease (CD) and ulcerative colitis (UC) in first-degree relatives of IBD patients living in a well-defined area. METHODS: IBD patients known at the IBD Registration South Limburg as well as population controls were asked about the occurrence of IBD in their first-degree relatives. RESULTS: IBD was reported and confirmed in 16 (out of 1554) relatives by 11 (out of 245) patients. Prevalence of IBD was highest for siblings (1.5%) and children (1.3%), while only 0.2% of the parents were affected with IBD. Among relatives of the control subjects, IBD was observed in 0.8% (versus 4.5% in IBD patients), resulting in an odds ratio of 5.7 (95% CI: 2.0-16.7). CONCLUSIONS: The observed risk of IBD for first-degree relatives of IBD patients was higher than in controls. However, the risk in our population is lower than has been reported by other centres, possibly because of the population-based character of our study.
Subject(s)
Colitis, Ulcerative/genetics , Crohn Disease/genetics , Adolescent , Adult , Aged , Aged, 80 and over , Colitis, Ulcerative/epidemiology , Crohn Disease/epidemiology , Female , Humans , Male , Middle Aged , Netherlands/epidemiologyABSTRACT
Downhill oesophagus varices are rarely observed. In this report a patient is described with downhill oesophagus varices in the absence of the vena cava superior syndrome. The observation of these varices was the clue to the diagnosis of a serious disease: a malignant thymoma.
Subject(s)
Esophageal Neoplasms/diagnosis , Esophageal and Gastric Varices/diagnosis , Thymoma/diagnosis , Aged , Diagnosis, Differential , Esophageal Neoplasms/surgery , Esophageal and Gastric Varices/etiology , Humans , Male , Superior Vena Cava Syndrome , Thymoma/surgery , Tomography, X-Ray ComputedABSTRACT
We determined serum ferritin, C-reactive protein (CRP), fibrinogen, and the erythrocyte sedimentation rate (ESR) in 73 patients with anemia of chronic disease. Nomograms of CRP, ESR, or fibrinogen vs ferritin concentrations were constructed and used to estimate the iron store in bone marrow. Iron stores estimated from the nomograms were compared with the results of staining cytological bone marrow smears for iron, the reference method for evaluating iron in bone marrow. In contrast to the results of Witte et al. (Clin Chem 1985;31:1011; Am J Clin Pathol 1986;85:202-6 and 1988;90:85-7), we observed that nomograms of CRP, fibrinogen, or ESR (i.e., acute-phase reactants not influenced by changes in iron metabolism) vs ferritin are not suitable to correct for the acute-phase component of changes in ferritin concentrations. For ferritin concentrations less than 70 micrograms/L, we found that iron deficiency, as judged from bone marrow iron stain, apparently was always present.
Subject(s)
Anemia, Hypochromic/metabolism , Bone Marrow/metabolism , Ferritins/blood , Blood Sedimentation , Bone Marrow/chemistry , C-Reactive Protein/isolation & purification , C-Reactive Protein/metabolism , Female , Fibrinogen/isolation & purification , Fibrinogen/metabolism , Humans , Immunoenzyme Techniques , Male , Predictive Value of Tests , Reference ValuesSubject(s)
Hemochromatosis/diagnosis , Iron/analysis , Liver/analysis , Adult , Aged , Diagnosis, Differential , Hemochromatosis/genetics , Hemochromatosis/metabolism , Humans , Middle AgedSubject(s)
Hemochromatosis/diagnosis , Adult , Diagnosis, Differential , Female , Hemochromatosis/complications , Hemochromatosis/genetics , Humans , Iron/metabolism , Joint Diseases/diagnosis , Joint Diseases/diagnostic imaging , Joint Diseases/etiology , Liver/metabolism , Liver/pathology , Male , Middle Aged , Pedigree , RadiographySubject(s)
Colonic Diseases/diagnosis , Duodenal Diseases/diagnosis , Intestinal Fistula/diagnosis , Adenocarcinoma/complications , Aged , Colonic Diseases/etiology , Colonic Diseases/surgery , Colonic Neoplasms/complications , Duodenal Diseases/etiology , Duodenal Diseases/surgery , Female , Humans , Intestinal Fistula/etiology , Intestinal Fistula/surgeryABSTRACT
Results are presented from the determination of tissue iron and ferritin in 15 pathological livers (6 with steatosis, 8 with fibrosis/cirrhosis and 1 with haemochromatosis). The histological assessment according to the Rowe system, after Perls' staining, was compared with the measurement of the iron content in liver homogenate by flameless atomic absorption spectrophotometry. The results of the flameless atomic absorption spectrophotometry were less accurate than in normal livers, but the method can still be considered reliable with satisfactory precision. As in normal livers, the range of chemically determined values in the histological staining grades was considerable and there was quite an overlap between consecutive grades. The chemical determination of liver iron content is to be preferred. The levels of ferritin protein and ferritin iron follow the same pattern as the total iron content.
Subject(s)
Ferritins/analysis , Iron/analysis , Liver Diseases/metabolism , Humans , Spectrophotometry, AtomicABSTRACT
A 57 year old ex-miner, who had been treated for his psoriasis with methotrexate 5 mg 3 times a week, taken orally (in total +/- 12 g) developed in the spring 1985 the symptoms of an allergic pneumonia. In biopsies of lung and liver non-caseating granulomata were found, compatible with the diagnosis sarcoidosis. The question whether one clinical entity is concerned or two superponed diseases, remains unanswered.
Subject(s)
Chemical and Drug Induced Liver Injury , Granuloma/chemically induced , Lung Diseases/chemically induced , Methotrexate/adverse effects , Sarcoidosis/etiology , Blood Gas Analysis , Body Temperature , Diagnosis, Differential , Granuloma/diagnosis , Granuloma/pathology , Humans , Liver/pathology , Liver Diseases/diagnosis , Liver Diseases/pathology , Lung Diseases/diagnostic imaging , Male , Middle Aged , Radiography , Respiratory Function Tests , Sarcoidosis/diagnosis , Sarcoidosis/pathologySubject(s)
Puerperal Disorders/therapy , Uterine Diseases/therapy , Adult , Female , Humans , PregnancyABSTRACT
Uterine inversion is a rare condition that occurs in various degrees. Predisposing and etiologic factors are discussed, as are therapy and prophylaxis. These points are illustrated by 4 own cases and by 172 cases collected from literature.
