Heterogeneity Between States in the Health and Economic Impact of Measles Immunization in the United States.

BACKGROUND: Vaccines have been used successfully for disease elimination programs in many countries. Evidence on the impact of vaccination programs can support decision-making among medical practitioners and policy makers to improve immunization rates. We estimated the health and economic impact of measles vaccination for each of the 48 contiguous states and the District of Columbia since 1964. METHODS: For each state, we fitted multiple time-series models to prevaccination data and used the best-fitting model to predict counterfactual cases that would have occurred in the absence of vaccination. We then subtracted observed from counterfactual measles cases, deaths, and related costs to estimate the impact of vaccination. RESULTS: We estimated that 149 million children were vaccinated against measles in the United States between 1964 and 2014, at a cost of $12.2 billion, and that vaccination prevented 29.8 million cases, 32 000 deaths, and $25.8 billion in societal costs. The impact exceeded the national average in 70% of Western and Northeastern states, compared with only 24% of Southern and Midwestern states. CONCLUSIONS: The significant health and economic benefit of measles vaccination in the United States should encourage continued investments to sustain and expand vaccination programs globally.

Health impact of the 2004 Andaman Nicobar earthquake and tsunami in Indonesia.

BACKGROUND: The human impact of the tsunami that occurred on 26 December 2004 was enormous, with Indonesia bearing a huge proportion of the losses. The aftermath brought predictions of communicable disease outbreaks and widespread fear of epidemics. However, evidence from previous disasters due to natural hazards does not support all of these predictions. The objectives of this study were to: (1) describe the relative importance of infectious diseases and injuries as a consequence of a disaster due to natural hazards; and (2) identify key recommendations for the improvement of control and surveillance of these diseases during and after disasters. METHODS: A team from the Center for Research on the Epidemiology of Disasters visited Jakarta and Banda Aceh from 11-23 January 2005, and collected data from the Central and Provincial Ministries of Health (MOH), the World Health Organization (WHO), and a field hospital from the International Committee of the Red Cross in Banda Aceh. The epidemiological profiles of diseases before and after the tsunami were compared. Cholera, tetanus, wounds and wound infections, acute respiratory infections, malaria, and dengue were included in this analysis. RESULTS: Certain diseases (e.g., cholera, malaria, dengue) are not always an immediate priority post-disaster. Rates of disaster-related health conditions requiring emergency response fell by half, and became negligible around four weeks after the precipitating events. Some conditions, such as aspiration pneumonia and tetanus, which normally are rare, require special preparedness for emergency personnel. In addition, resistant and rare pathogens are associated with disasters due to natural hazards in the tropics and require specialized knowledge for the rapid and successful treatment of related infections. CONCLUSIONS: Within the first four weeks of a disaster, international humanitarian agencies in the health sector should start working with the MOH. The WHO surveillance system established immediately after the tsunami offers lessons for developing a prototype for future emergencies. Guidelines for tetanus and aspiration pneumonia should be included in disaster medicine handbooks, and humanitarian aid groups should be prepared to provide emergency obstetrics and post-natal services. Relief funding after naturally occurring disasters should consider funding sustainability. Donors should know when to stop providing emergency relief funds and transition to recovery/development strategies.

Short communication: patterns of chronic and acute diseases after natural disasters - a study from the International Committee of the Red Cross field hospital in Banda Aceh after the 2004 Indian Ocean tsunami.

OBJECTIVE: To assess the pattern of diseases in a natural disaster, which are not necessarily a direct consequence of the event but can impact on the way health assistance is to be provided. METHODS: Cross-sectional, record-based study in the International Committee of the Red Cross field hospital in Aceh, Indonesia, established immediately after the tsunami in 2004. Patients who presented to hospital from January 15 to 31, and whose diagnoses were available, were included in the study. RESULTS: One thousand one hundred and eighty-eight residents of Aceh participated. 43.5% of the diagnoses was chronic diseases. The odds of chronic vs. acute diseases increased by 16.4% per day up to January 23 [95% confidence interval (CI): 7.8-25.6%] and decreased thereafter by 13.1% (95% CI: 6.6-19.1%) per day. The odds of acute diseases were 34% lower among females than males (95% CI: 16-49%) and 4.3 times higher among children than the rest of the population (95% CI: 2.4-7.6). There were relatively few trauma cases among females and children. CONCLUSIONS: Medical teams providing relief after acute disasters should be prepared to provide healthcare for chronic diseases too. A delay in the presentation of many acute conditions has implications for long-term health consequences of disasters, such as disability.

The importance of conflict-related mortality in civilian populations.

Civil conflict affects the health of individuals in many countries, and draws a substantial amount of international humanitarian aid. The most widely used indicator of the effect of conflict is the rate of civilian death during conflict. We aimed to assess mortality estimates from conflicts in Sudan, Somalia, the Democratic Republic of Congo, and Afghanistan by calculating the relative risk of death during and after conflict compared with that in preconflict peacetime. Katale, in the Democratic Republic of Congo, had the highest relative risk of death during conflict (11.2 [9.1-13.8] and 103.3 [94.7-112.6], for children younger than 5 years and the whole population, respectively). Our results suggest that high rates of civilian mortality are determined more by the pre-existing fragility of the affected population than the intensity of the conflict. In many instances, a high rate of civilian deaths during conflict shows that international development aid before the conflict was grossly inadequate.