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Agents Actions Suppl ; 31: 123-6, 1990.
Article in English | MEDLINE | ID: mdl-1981962

ABSTRACT

The inflammatory mediators PGE2, DC-PGI2 and histamine as well as the beta-adrenergic drugs isoprenaline and salbutamol increase intracellular cyclic AMP-concentrations whereas Platelet Activating Factor does not induce any change in adenyl cyclase activity of normal human alveolar macrophages. Functional H2-histaminergic and beta 2-adrenergic receptor-subtypes are coupled to macrophage adenyl cyclase.


Subject(s)
Adenylyl Cyclases/metabolism , Macrophages/enzymology , Pulmonary Alveoli/enzymology , Adrenergic beta-Agonists/pharmacology , Adult , Cyclic AMP/metabolism , Female , Histamine/pharmacology , Humans , Male , Prostaglandins/pharmacology , Pulmonary Alveoli/cytology , Pulmonary Alveoli/metabolism
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