Impact of Acoustic Noise Reduction on Patient Experience in Routine Clinical Magnetic Resonance Imaging.

OBJECTIVES: Acoustic noise emission from MRI scanners is considered a major factor of patient discomfort during routine MRI examinations. We prospectively evaluated the impact of acoustic noise reduction using software implementations in routine clinical MRI on subjective patient experience and image quality. METHODS: Two-hundred consecutive patients undergoing one of four MRI examinations (brain, lumbar spine, shoulder, and knee) at a single center were prospectively randomized into two groups at a 1 to 1 ratio: standard MRI examination and MRI examination with acoustic noise reduction. After the examination, patients were asked to complete a questionnaire aimed at defining their subjective experience (primary endpoint). Two readers assessed subjective image quality of all patient studies in consensus (secondary endpoint). Nonparametric tests and logistic regression models were used for statistical analysis. RESULTS: Hundred-seventy-four patients were included in the final study. Patients in the intervention group felt less discomforted by the acoustic noise (p = 0.01) and reported increased audibility of music through the headphones (p = 0.03). No significant difference in subjective image quality was found. CONCLUSION: Our study indicates that the effects of acoustic noise reduction in routine clinical MRI can be translated into reduced patient discomfort from acoustic noise and improved audibility of music. Acoustic noise reduction thus significantly contributes to increased patient comfort during MRI examinations.

Spiral gradient echo versus cartesian turbo spin echo imaging for sagittal contrast-enhanced fat-suppressed T1 weighted spine MRI: an inter-individual comparison study.

OBJECTIVES: To compare a novel 3D spiral gradient echo (GRE) sequence with a conventional 2D cartesian turbo spin echo (TSE) sequence for sagittal contrast-enhanced (CE) fat-suppressed (FS) T1 weighted (T1W) spine MRI. METHODS: In this inter-individual comparison study, 128 patients prospectively underwent sagittal CE FS T1W spine MRI with either a 2D cartesian TSE ("TSE", 285 s, 64 patients) or a 3D spiral GRE sequence ("Spiral", 93 s, 64 patients). Between both groups, patients were matched in terms of anatomical region (cervical/thoracic/lumbar spine and sacrum). Three readers used 4-point Likert scales to assess images qualitatively in terms of overall image quality, presence of artifacts, spinal cord visualization, lesion conspicuity and quality of fat suppression. RESULTS: Spiral achieved a 67.4% scan time reduction compared to TSE. Interreader agreement was high (alpha=0.868-1). Overall image quality (4;[3,4] vs 3;[3,4], p<0.001 - p=0.002 for all readers), presence of artifacts (4;[3,4] vs 3;[3,4] p=0.027 - p=0.046 for all readers), spinal cord visualization (4;[4,4] vs 4;[3,4], p<0.001 for all readers), lesion conspicuity (4;[4,4] vs 4;[4,4], p=0.016 for all readers) and quality of fat suppression (4;[4,4] vs 4;[4,4], p=0.027 - p=0.033 for all readers), were all deemed significantly improved by all three readers on Spiral images as compared to TSE images. CONCLUSION: We demonstrate the feasibility of a novel 3D spiral GRE sequence for improved and rapid sagittal CE FS T1W spine MRI. ADVANCES IN KNOWLEDGE: A 3D spiral GRE sequence allows for improved sagittal CE FS T1W spine MRI at very short scan times.

Contrast-Enhanced T1-Weighted Head and Neck MRI: Prospective Intraindividual Image Quality Comparison of Spiral GRE, Cartesian GRE, and Cartesian TSE Sequences.

BACKGROUND. Sequences with noncartesian k-space sampling may improve image quality of head and neck MRI. OBJECTIVE. The purpose of this study was to compare intraindividually the image quality of a spiral gradient-recalled echo (GRE) sequence and conventional cartesian GRE and cartesian turbo spin-echo (TSE) sequences for contrast-enhanced T1-weighted head and neck MRI. METHODS. This prospective study included patients referred for contrast-enhanced head and neck MRI from August 2020 to May 2021. Patients underwent 1.5-T MRI including contrast-enhanced spiral GRE (2 minutes 28 seconds), cartesian GRE (4 minutes 27 seconds), and cartesian TSE (3 minutes 41 seconds) sequences, acquired in rotating order across patients. Three radiologists independently assessed image quality measures, including conspicuity of prespecified lesions, using 5-point Likert scales. One reader measured maximal extent of dental material artifact and contrast-to-noise ratio (CNR). RESULTS. Thirty-one patients (13 men, 18 women; mean age, 63.8 years) were enrolled. Nineteen patients had a focal lesion; 22 had dental material. Interreader agreement for image quality measures was substantial to excellent (Krippendorff alpha, 0.681-1.000). Scores for overall image quality (whole head and neck, neck only, and head only), pulsation artifact, muscular contour delineation, vessel contour delineation, motion artifact, and differentiation between mucosa and pharyngeal muscles were significantly better for spiral GRE than for cartesian GRE and cartesian TSE for all readers (p < .05). Scores for lesion conspicuity (whole head and neck, neck only, and head only), quality of fat suppression, flow artifact, and foldover artifact were not significantly different between spiral GRE and the cartesian sequences for any reader (p > .05). Dental material artifact scores were significantly worse for spiral GRE than the other sequences for all readers (p < .05). The mean maximum extent of dental material artifact was 39.6 ± 25.5 (SD) mm for spiral GRE, 35.6 ± 24.3 mm for cartesian GRE, and 29.6 ± 21.4 mm for cartesian TSE; the mean CNR was 221.1 ± 94.5 for spiral GRE, 151.8 ± 85.7 for cartesian GRE, and 153.0 ± 63.2 for cartesian TSE (p < .001 between spiral GRE and other sequences for both measures). CONCLUSION. Three-dimensional spiral GRE improves subjective image quality and CNR of head and neck MRI with shorter scan time versus cartesian sequences, though it exhibits larger dental material artifact. CLINICAL IMPACT. A spiral sequence may help overcome certain challenges of conventional cartesian sequences for head and neck MRI.

Spiral 3D time-of-flight MR angiography for rapid non-contrast carotid artery imaging: Clinical feasibility and protocol optimization.

PURPOSE: To assess the clinical feasibility of spiral 3D Time-Of-Flight (TOF) MR Angiography (MRA) sequence variants for rapid non-contrast carotid artery imaging. METHODS: Nine different 3D TOF MRA sequences were acquired in nine healthy volunteers on a standard clinical 1.5 T scanner. Three cartesian sequences (fully sampled (10:15 min), accelerated with SENSE (05:08 min), accelerated with Compressed SENSE (03:32 min)) and six different spiral sequences were acquired (spiral acquisition windows ranging from 10 to 5 ms (01:32 min-03:05 min)). Three readers graded the images qualitatively in terms of overall image quality, vessel sharpness, inhomogeneous intraluminal signal, background noise, visualization of large and small vessels and overall impression of the number of visible vessels. Cross-sectional areas of the vessel lumen were measured and vessel sharpness was quantified. RESULTS: The SENSE and Compressed SENSE accelerated cartesian sequences and the Spiral 6 ms and 5 ms sequences were deemed comparable to the fully sampled cartesian sequence in most qualitative categories (p > 0.05) based on exact binomial tests. The Spiral 6 ms and 5 ms sequences achieved a scan time reduction of 75.3% and 69.9% respectively compared to the fully sampled cartesian sequence. The spiral sequences (generally) exhibited improved subjective vessel sharpness (p < 0.01-p = 0.13) but increased background noise (p = 0.03-p = 0.25). Cross-sectional area measurements were similar between all sequences (Krippendorff's alpha: 0.955-0.982). Quantitative vessel sharpness was increased for all spiral sequences compared to all cartesian sequences (p = 0.004). CONCLUSIONS: Spiral 3D TOF MRA sequences with a spiral acquisition window of 5 ms or 6 ms may be used for accurate, rapid, clinical non-contrast carotid artery imaging.

Single shot zonal oblique multislice SE-EPI diffusion-weighted imaging with low to ultra-high b-values for the differentiation of benign and malignant vertebral spinal fractures.

PURPOSE: To investigate the diagnostic yield of low to ultra-high b-values for the differentiation of benign from malignant vertebral fractures using a state-of-the-art single-shot zonal-oblique-multislice spin-echo echo-planar diffusion-weighted imaging sequence (SShot ZOOM SE-EPI DWI). MATERIALS AND METHODS: 66 patients (34 malignant, 32 benign) were examined on 1.5 T MR scanners. ADC maps were generated from b-values of 0,400; 0,1000 and 0,2000s/mm2. ROIs were placed into the fracture of interest on ADC maps and trace images and into adjacent normal vertebral bodies on trace images. The ADC of fractures and the Signal-Intensity-Ratio (SIR) of fractures relative to normal vertebral bodies on trace images were considered quantitative metrics. The appearance of the fracture of interest was graded qualitatively as iso-, hypo-, or hyperintense relative to normal vertebrae. RESULTS: ADC achieved an area under the curve (AUC) of 0.785/0.698/0.592 for b = 0,400/0,1000/0,2000s/mm2 ADC maps respectively. SIR achieved an AUC of 0.841/0.919/0.917 for b = 400/1000/2000s/mm2 trace images respectively. In qualitative analyses, only b = 2000s/mm2 trace images were diagnostically valuable (sensitivity:1, specificity:0.794). Machine learning models incorporating all qualitative and quantitative metrics achieved an AUC of 0.95/0.98/0.98 for b-values of 400/1000/2000s/mm2 respectively. The model incorporating only qualitative metrics from b = 2000s/mm2 achieved an AUC of 0.97. CONCLUSION: By using quantitative and qualitative metrics from SShot ZOOM SE-EPI DWI, benign and malignant vertebral fractures can be differentiated with high diagnostic accuracy. Importantly qualitative analysis of ultra-high b-value images may suffice for differentiation as well.

Amide proton transfer weighted (APTw) imaging based radiomics allows for the differentiation of gliomas from metastases.

We sought to evaluate the utility of radiomics for Amide Proton Transfer weighted (APTw) imaging by assessing its value in differentiating brain metastases from high- and low grade glial brain tumors. We retrospectively identified 48 treatment-naïve patients (10 WHO grade 2, 1 WHO grade 3, 10 WHO grade 4 primary glial brain tumors and 27 metastases) with either primary glial brain tumors or metastases who had undergone APTw MR imaging. After image analysis with radiomics feature extraction and post-processing, machine learning algorithms (multilayer perceptron machine learning algorithm; random forest classifier) with stratified tenfold cross validation were trained on features and were used to differentiate the brain neoplasms. The multilayer perceptron achieved an AUC of 0.836 (receiver operating characteristic curve) in differentiating primary glial brain tumors from metastases. The random forest classifier achieved an AUC of 0.868 in differentiating WHO grade 4 from WHO grade 2/3 primary glial brain tumors. For the differentiation of WHO grade 4 tumors from grade 2/3 tumors and metastases an average AUC of 0.797 was achieved. Our results indicate that the use of radiomics for APTw imaging is feasible and the differentiation of primary glial brain tumors from metastases is achievable with a high degree of accuracy.

Qualitative and Quantitative Analysis of a Spiral Gradient Echo Sequence for Contrast-Enhanced Fat-Suppressed T1-Weighted Spine Magnetic Resonance Imaging.

OBJECTIVES: Pulse sequences with non-Cartesian k-space sampling enable improved imaging in anatomical areas with high degrees of motion artifacts. We analyzed a novel spiral 3-dimensional (3D) gradient echo (GRE) magnetic resonance imaging (MRI) sequence ("spiral," 114.7 ± 11 seconds) and compared it with a radial 3D GRE ("vane," 216.7 ± 2 seconds) and a conventional Cartesian 2D turbo spin echo (TSE) sequence ("TSE," 266.7 ± 82 seconds) for contrast-enhanced fat-suppressed T1-weighted spine imaging. MATERIALS AND METHODS: Forty consecutive patients referred for contrast-enhanced MRI were prospectively scanned with all 3 sequences. A qualitative analysis was performed by 3 readers using 4- or 5-point Likert scales to independently grade images in terms of overall image quality, occurrence of artifacts, lesion conspicuity, and conspicuity of nerve roots. The numbers of visible nerve roots per sequence and patient were counted in consensus. Coefficient of variation measurements were performed for the paravertebral musculature (CVPM) and the spinal cord (CVSC). RESULTS: Spiral (median [interquartile range], 5 [4-5]) exhibited improved overall image quality in comparison to TSE (3 [3-4]) and vane (4 [4-5]; both P < 0.001). Vane surpassed TSE in terms of overall image quality (P < 0.001). Spiral (4 [3.75-4]) and vane (3.5 [3-4]) presented with less artifacts than TSE (3 [2.75-3.25]; both P < 0.001). Spiral (4 [4-5]) outperformed vane (4 [3-5]; P = 0.01) and TSE (4 [3-4]; P = 0.04) in terms of lesion conspicuity. Conspicuity of nerve roots was superior on spiral (3 [3-4]) and vane (4 [3-4]) when compared with TSE (1.5 [1-2]; both P < 0.001). Readers discerned significantly more nerve roots on spiral (4 [2.75-8]) and vane (4 [3.75-7.25]) images when compared with TSE (2 [0-4]; both P < 0.001). Interreader agreement ranged from moderate (α = 0.639) to almost perfect (α = 0.967). CVPM and CVSC were significantly lower on spiral as compared with vane and TSE (P < 0.001, P = 0.04). Vane exhibited lower CVPM and CVSC than TSE (P < 0.001, P = 0.01). CONCLUSIONS: A novel spiral 3D GRE sequence improves contrast-enhanced fat-suppressed T1-weighted spinal imaging qualitatively and quantitatively in comparison with a conventional Cartesian 2D TSE sequence and to a lesser extent with a radial 3D GRE sequence at shorter scan times.

Diffusion-weighted MRI of ischemic stroke at 3T: Value of synthetic b-values.

OBJECTIVES: Diffusion-weighted imaging (DWI) plays a crucial role in the diagnosis of ischemic stroke. We assessed the value of computed and acquired high b-value DWI in comparison with conventional b = 1000 s mm-2 DWI for ischemic stroke at 3T. METHODS: We included 36 patients with acute ischemic stroke who presented with diffusion abnormalities on DWI performed within 24 h of symptom onset. B-values of 0, 500, 1000 and 2000 s mm-2 were acquired. Synthetic images with b-values of 1000, 1500, 2000 and 2500 s mm-2 were computed. Two readers compared synthetic (syn) and acquired (acq) b = 2000 s mm-2 images with acquired b = 1000 s mm-2 images in terms of lesion detection rate, image quality, presence of uncertain hyperintensities and lesion conspicuity. Readers also selected their preferred b-value. Contrast ratio (CR) measurements were performed. Non-parametrical statistical tests and weighted Cohens' κ tests were computed. RESULTS: Syn1000 and syn1500 matched acq1000 images in terms of lesion detection rate, image quality and presence of uncertain hyperintensities but presented with significantly improved lesion conspicuity (p < 0.01) and were frequently selected as preferred b-values. Acq2000 images exhibited a similar lesion detection rate and improved lesion conspicuity (p < 0.01) but worse image quality (p < 0.01) than acq1000 images. Syn2000 and syn2500 images performed significantly worse (p < 0.01) than acq1000 images in most or all categories. CR significantly increased with increasing b-values. CONCLUSION: Synthetic images at b = 1000 and 1500 s mm-2 and acquired DWI images at b = 2000 s mm-2 may be of clinical value due to improved lesion conspicuity. ADVANCES IN KNOWLEDGE: Synthetic b-values enable improved lesion conspicuity for DWI of ischemic stroke.

Spiral 3-Dimensional T1-Weighted Turbo Field Echo: Increased Speed for Magnetization-Prepared Gradient Echo Brain Magnetic Resonance Imaging.

OBJECTIVES: Spiral magnetic resonance imaging acquisition may enable improved image quality and higher scan speeds than Cartesian trajectories. We tested the performance of four 3D T1-weighted (T1w) TFE sequences (magnetization-prepared gradient echo magnetic resonance sequence) with isotropic spatial resolution for brain imaging at 1.5 T in a clinical patient cohort based on qualitative and quantitative image quality metrics. Two prototypical spiral TFE sequences (spiral 1.0 and spiral 0.85) and a Cartesian compressed sensing technology accelerated TFE sequence (CS 2.5; acceleration factor of 2.5) were compared with a conventional (reference standard) Cartesian parallel imaging accelerated TFE sequence (SENSE; acceleration factor of 1.8). MATERIALS AND METHODS: The SENSE (5:52 minutes), CS 2.5 (3:17 minutes), and spiral 1.0 (2:16 minutes) sequences all had identical spatial resolutions (1.0 mm). The spiral 0.85 (3:47 minutes) had a higher spatial resolution (0.85 mm). The 4 TFE sequences were acquired in 41 patients (20 with and 21 without contrast media). Three readers rated qualitative image quality (12 categories) and selected their preferred sequence for each patient. Two readers performed quantitative analysis whereby 6 metrics were derived: contrast-to-noise ratio for white and gray matter (CNRWM/GM), contrast ratio for gray matter-CSF (CRGM/CSF), and white matter-CSF (CRWM/CSF); and coefficient of variations for gray matter (CVGM), white matter (CVWM), and CSF (CVCSF). Friedman tests with post hoc Nemenyi tests, exact binomial tests, analysis of variance with post hoc Dunnett tests, and Krippendorff alphas were computed. RESULTS: Concerning qualitative analysis, the CS 2.5 sequence significantly outperformed the SENSE in 4/1 (with/without contrast) categories, whereas the spiral 1.0 and spiral 0.85 showed significantly improved scores in 10/9and 7/7 categories, respectively (P's < 0.001-0.039). The spiral 1.0 was most frequently selected as the preferred sequence (reader 1, 10/15 times; reader 2, 9/12 times; reader 3, 11/13times [with/without contrast]). Interreader agreement ranged from substantial to almost perfect (alpha = 0.615-0.997). Concerning quantitative analysis, compared with the SENSE, the CS 2.5 had significantly better scores in 2 categories (CVWM, CVCSF) and worse scores in 2 categories (CRGM/CSF, CRWM/CSF), the spiral 1.0 had significantly improved scores in 4 categories (CNRWM/GM, CRGM/CSF, CRWM/CSF, CVWM), and the spiral 0.85 had significantly better scores in 2 categories (CRGM/CSF, CRWM/CSF). CONCLUSIONS: Spiral T1w TFE sequences may deliver high-quality clinical brain imaging, thus matching the performance of conventional parallel imaging accelerated T1w TFEs. Imaging can be performed at scan times as short as 2:16 minutes per sequence (61.4% scan time reduction compared with SENSE). Optionally, spiral imaging enables increased spatial resolution while maintaining the scan time of a Cartesian-based acquisition schema.

Clinical feasibility of ultrafast intracranial vessel imaging with non-Cartesian spiral 3D time-of-flight MR angiography at 1.5T: An intra-individual comparison study.

OBJECTIVES: Non-Cartesian Spiral readout can be implemented in 3D Time-of-flight (TOF) MR angiography (MRA) with short acquisition times. In this intra-individual comparison study we evaluated the clinical feasibility of Spiral TOF MRA in comparison with compressed sensing accelerated TOF MRA at 1.5T for intracranial vessel imaging as it has yet to be determined. MATERIALS AND METHODS: Forty-four consecutive patients with suspected intracranial vascular disease were imaged with two Spiral 3D TOFs (Spiral, 0.82x0.82x1.2 mm3, 01:32 min; Spiral 0.8, 0.8x0.8x0.8 mm3, 02:12 min) and a Compressed SENSE accelerated 3D TOF (CS 3.5, 0.82x0.82x1.2 mm3, 03:06 min) at 1.5T. Two neuroradiologists assessed qualitative (visualization of central and peripheral vessels) and quantitative image quality (Contrast Ratio, CR) and performed lesion and variation assessment for all three TOFs in each patient. After the rating process, the readers were questioned and representative cases were reinspected in a non-blinded fashion. For statistical analysis, the Friedman and Nemenyi post-hoc test, Kendall W tests, repeated measure ANOVA and weighted Cohen's Kappa tests were used. RESULTS: The Spiral and Spiral 0.8 outperformed the CS 3.5 in terms of peripheral image quality (p<0.001) and performed equally well in terms of central image quality (p>0.05). The readers noted slight differences in the appearance of maximum intensity projection images. A good to high degree of interstudy agreement between the three TOFs was observed for lesion and variation assessment (W = 0.638, p<0.001 -W = 1, p<0.001). CR values did not differ significantly between the three TOFs (p = 0.534). Interreader agreement ranged from good (K = 0.638) to excellent (K = 1). CONCLUSIONS: Compared to the CS 3.5, both the Spiral and Spiral 0.8 exhibited comparable or better image quality and comparable diagnostic performance at much shorter acquisition times.

Ultrafast Intracranial Vessel Imaging With Non-Cartesian Spiral 3-Dimensional Time-of-Flight Magnetic Resonance Angiography at 1.5 T: An In Vitro and Clinical Study in Healthy Volunteers.

OBJECTIVES: Non-Cartesian spiral magnetic resonance (MR) acquisition may enable higher scan speeds, as the spiral traverses the k-space more efficiently per given time than in Cartesian trajectories. Spiral MR imaging can be implemented in time-of-flight (TOF) MR angiography (MRA) sequences. In this study, we tested the performance of five 3-dimensional TOF MRA sequences for intracranial vessel imaging at 1.5 T with qualitative and quantitative image quality metrics based on in vitro and in vivo measurements. Specifically, 3 novel spiral TOF MRA sequences (spiral-TOFs) and a compressed sensing (CS) technology-accelerated TOF MRA sequence (CS 3.5) were compared with a conventional (criterion standard) parallel imaging-accelerated TOF MRA sequence (SENSE). MATERIALS AND METHODS: The SENSE sequence (5:08 minutes) was compared with the CS 3.5 sequence (3:06 minutes) and a spiral-TOF (spiral, 1:32 minutes), all with identical resolutions. In addition, 2 further isotropic spiral-TOFs (spiral 0.8, 2:12 minutes; spiral 0.6, 5:22 minutes) with higher resolution were compared with the SENSE. First, vessel tracking experiments were performed in vitro with a dedicated vascular phantom to determine possible differences in the depiction of cross-sectional areas of vessel segments. For the in vitro tests, an additional 3-dimensional proton density-weighted sequence was added for comparison reasons. Second, 3 readers blinded to sequence details assessed qualitative (16 features) and 2 readers assessed quantitative (contrast-to-noise ratio [CNR], contrast ratio [CR], vessel sharpness, and full width at half maximum edge criterion measurements) image quality based on images acquired from scanning 10 healthy volunteers with all 5 TOF sequences. Scores from quantitative image quality analysis were compared with Kruskal-Wallis, analysis of variance, or Welch's analysis of variance, followed by Dunnett's or Dunnett's T3 post hoc tests. Scores from qualitative image quality analysis were compared with exact binomial tests, and the level of interreader agreement was determined with Krippendorff's alpha. RESULTS: Concerning the in vitro tests, there were no significant differences between the 5 TOFs and the proton density-weighted sequence in measuring cross-sectional areas of vessel segments (P = 0.904). As for the in vivo tests, the CS 3.5 exhibited equal qualitative image quality as the SENSE, whereas the 3 spiral-TOFs outperformed the SENSE in several categories (P values from 0.002 to 0.031). Specifically, the spiral 0.8 and 0.6 sequences achieved significantly higher scores in 12 categories. Interreader agreement ranged from poor (alpha = -0.013, visualization of internal carotid artery segment C7) to substantial (alpha = 0.737, number of vessels visible, sagittal). As for the quantitative metrics, the CS 3.5 and all 3 spiral-TOFs presented with significantly worse CNR than the SENSE ([mean ± SD] SENSE 37.48 ± 7.13 vs CS 3.5 31.14 ± 5.97 vs spiral 19.77 ± 1.65 vs spiral 0.8 16.18 ± 2.14 vs spiral 0.6 10.37 ± 1.05). The CR values did not differ significantly between the SENSE and the other TOFs except for the spiral sequence that showed significantly improved CR (SENSE 0.53 ± 0.03 vs spiral 0.56 ± 0.03). As for vessel sharpness, the SENSE was outperformed by all spiral-TOFs (SENSE 0.37 ± 0.03 vs spiral 0.52 ± 0.07 vs spiral 0.8 0.53 ± 0.08 vs spiral 0.6 0.73 ± 0.09), whereas the CS 3.5 performed equally well (SENSE 0.37 ± 0.03 vs CS 3.5 0.37 ± 0.03). Full width at half maximum values did not differ significantly between any TOF. CONCLUSIONS: Spiral-TOFs may deliver high-quality intracranial vessel imaging thus matching the performance of conventional parallel imaging-accelerated TOFs (such as the SENSE). Specifically, imaging can be performed at unprecedented scan times as short as 1:32 minutes per sequence (70.12% scan time reduction compared with SENSE). Optionally, spiral imaging may also be used to increase spatial resolution while maintaining the scan time of a Cartesian-based acquisition schema. The CNR was decreased in spiral-TOF images.

Compressed SENSE accelerated 3D T1w black blood turbo spin echo versus 2D T1w turbo spin echo sequence in pituitary magnetic resonance imaging.

PURPOSE: To compare image quality between a 2D T1w turbo spin echo (TSE) sequence and a Compressed SENSE accelerated 3D T1w black blood TSE sequence (equipped with a black blood prepulse for blood signal suppression) in pre- and postcontrast imaging of the pituitary and to assess scan time reductions. METHODS AND MATERIALS: For this retrospective study, 56 patients underwent pituitary MR imaging at 3T. 28 patients were scanned with the 2D- and 28 patients with the accelerated 3D sequence. Two board certified neuroradiologists independently evaluated 13 qualitative image features (12 features on postcontrast- and 1 feature on precontrast images).SNR and CNR measurements were obtained. Interreader agreement was assessed with the intraclass correlation coefficient while differences in scores were assessed with exact Wilcoxon rank sum tests. RESULTS: The interreader agreement ranged from fair (visibility of the ophthalmic nerve, ICC = 0.57) to excellent (presence and severity of pulsation artefacts, ICC = 0.97). The Compressed SENSE accelerated 3D sequence outperformed the 2D sequence in terms of "overall image quality" (median: 4 versus 3, p = 0.04) and "presence and severity of pulsation artefacts" (median: 0 versus 1, p < 0.001). There were no significant differences in any other qualitative and quantitative (SNR, CNR) image quality features. Scan time was reduced by 03:53 min (33.1%) by replacing the 2D with the 3D sequence. CONCLUSION: The Compressed SENSE accelerated 3D T1w black blood TSE sequence is a reliable alternative for the standard 2D sequence in pituitary imaging. The black blood prepulse may aid in suppression of pulsation artefacts.

Reduction of procedure times in routine clinical practice with Compressed SENSE magnetic resonance imaging technique.

OBJECTIVES: Acceleration of MR sequences beyond current parallel imaging techniques is possible with the Compressed SENSE technique that has recently become available for 1.5 and 3 Tesla scanners, for nearly all image contrasts and for 2D and 3D sequences. The impact of this technique on examination timing parameters and MR protocols in a clinical setting was investigated in this retrospective study. MATERIAL AND METHODS: A numerical analysis of the examination timing parameters (scan time, exam time, procedure time, interscan delay time, changeover time, nonscan time) based on the MR protocols of 6 different body regions (brain, knee, lumbar spine, breast, shoulder) using MR log files was performed and the total number of examinations acquired from January to April both in 2017 and 2018 on a 1.5 T MR scanner was registered. Percentages, box plots and unpaired two-sided t tests were obtained for statistical evaluation. RESULTS: All examination timing parameters of the six anatomical regions analysed were significantly shortened after implementation of Compressed SENSE. On average, scan times were accelerated by 20.2% (p<0.0001) while procedure times were shortened by 16% (p<0.0001). Considering all anatomical regions and all MR protocols, 27% more examinations were performed over the same 4 month period in 2018 compared to 2017. CONCLUSION: Compressed SENSE allows for a significant acceleration of MR examinations and a considerable increase in the total number of MR examinations is possible.

Amide Proton Transfer Weighted Imaging Shows Differences in Multiple Sclerosis Lesions and White Matter Hyperintensities of Presumed Vascular Origin.

Objectives: To assess the ability of 3D amide proton transfer weighted (APTw) imaging based on magnetization transfer analysis to discriminate between multiple sclerosis lesions (MSL) and white matter hyperintensities of presumed vascular origin (WMH) and to compare APTw signal intensity of healthy white matter (healthy WM) with APTw signal intensity of MSL and WHM. Materials and Methods: A total of 27 patients (16 female, 11 males, mean age 39.6 years) with multiple sclerosis, 35 patients (17 females, 18 males, mean age 66.6 years) with small vessel disease (SVD) and 20 healthy young volunteers (9 females, 11 males, mean age 29 years) were included in the MSL, the WMH, and the healthy WM group. MSL and WMH were segmented on fluid attenuated inversion recovery (FLAIR) images underlaid onto APTw images. Histogram parameters (mean, median, 10th, 25th, 75th, 90th percentile) were calculated. Mean APTw signal intensity values in healthy WM were defined by "Region of interest" (ROI) measurements. Wilcoxon rank sum tests and receiver operating characteristics (ROC) curve analyses of clustered data were applied. Results: All histogram parameters except the 75 and 90th percentile were significantly different between MSL and WMH (p = 0.018-p = 0.034). MSL presented with higher median values in all parameters. The histogram parameters offered only low diagnostic performance in discriminating between MSL and WMH. The 10th percentile yielded the highest diagnostic performance with an AUC of 0.6245 (95% CI: [0.532, 0.717]). Mean APTw signal intensity values of MSL were significantly higher than mean values of healthy WM (p = 0.005). The mean values of WMH did not differ significantly from the values of healthy WM (p = 0.345). Conclusions: We found significant differences in APTw signal intensity, based on straightforward magnetization transfer analysis, between MSL and WMH and between MSL and healthy WM. Low AUC values from ROC analyses, however, suggest that it may be challenging to determine type of lesion with APTw imaging. More advanced analysis of the APT CEST signal may be helpful for further differentiation of MSL and WMH.