Four dimensional bolus tagging imaging of pulsatile flow.

Inversion bolus tagging MR methods were used to provide a graphic depiction of the axial velocity in three spatial dimensions for pulsatile flow through complex geometries. Visualization of the flow field was readily apparent, and a train of tagged boli were depicted providing an immediate overview of the displacement of flowing fluid over the entire pulsatile cycle. Tagging efficiency obtained using adiabatic inversion pulses was improved compared to that with a windowed sinc pulse. Results from phantom experiments on steady flow were correlated with computational fluid dynamic (CFD) simulations. The use of 3D methods reduced spatial partial volume effects, and the displacement of boli in a steady flow experiment correlated well with CFD simulations. The use of adiabatic inversion pulses resulted in sharp edged inversion regions with good retention of longitudinal magnetization. However in order to keep the pulse duration short, of the order of 2-5 ms, a rather large RF amplitude had to be used. The inversion bolus tagging method is useful in visualizing the flow field in multiple levels for pulsatile fluid flowing through complex geometries, and may be useful in fluid dynamic applications.

Calculation of the magnetization distribution for fluid flow in curved vessels.

The signal intensity in magnetic resonance angiography (MRA) images reflects both morphological and flow-related features of vascular anatomy. A thorough understanding of MRA, therefore, demands a careful analysis of flow-related effects. Computational fluid dynamics (CFD) methods are very powerful in determining flow patterns in 3D tortuous vessels for both steady and unsteady flow. Previous simulations of MRA images calculated the magnetization of flowing blood by tracking particles as they moved along flow streamlines that had been determined by a CFD calculation. This manuscript describes MRA simulations that use CFD calculations to determine magnetization variation at a fixed point and, therefore, do not require streamline tracking to calculate the distribution of magnetization in flowing fluids. This method inherently accounts for uniform particle density, avoids problems associated with tracking particles close to the wall, and is well-suited to modeling pulsatile flow.

Central intraluminal saturation stripe on MR angiograms of curved vessels: simulation, phantom, and clinical analysis.

PURPOSE: To investigate the appearance of reduced signal intensity in the center of blood vessels on magnetic resonance (MR) angiograms that can mimic intraluminal thrombus. MATERIALS AND METHODS: Simulations and phantom studies were performed to analyze MR angiogram appearance distal to a pronounced curve. RESULTS: Saturation effects substantially lower the signal strength in the center of the vessel relative to that at the vessel periphery. These effects appeared even though the flow was well ordered and laminar. In curved geometries, secondary flow patterns produced counter-rotating vortices, which moved the fastest-moving particles to the outside of the curve and folded the slow-moving particles to the center of the vessel. CONCLUSION: Imaging parameter choices that reduce saturation, such as acquisition of a two-dimensional section transverse to the vessel and through the questionable region, effectively eliminate the central hypointensity effect in vivo.

Cardiac-gated MR angiography of pulsatile flow: k-space strategies.

Signal strength in time-of-flight magnetic resonance (MR) angiography of pulsatile flow is modulated by the time-varying intraluminal magnetization strength. The specific appearance of MR angiographic images therefore depends on the relationship of different phase-encoding steps to the pulsatile flow waveform. Cardiac-phase gating can be applied with phase-encoding reordering to acquire different regions of k-space during the desired phases of the cardiac cycle. The authors have developed a simulation program for evaluating the merits of different encoding strategies for pulsatile flow. The model was validated with phantom studies. High signal intensity relative to that in conventional MR angiographic studies can be attained with strategies that impose relatively small penalties in total acquisition time.

MR imaging of flow through tortuous vessels: a numerical simulation.

A novel computer simulation technique is presented that allows the calculation of images from Magnetic Resonance Angiography (MRA) studies of blood flow in realistic curving and branching two-dimensional vessel geometries. Fluid dynamic calculations provide flow streamlines through curved or branching vessels. MR simulations generate images for specific MR pulse sequence parameters. Simulations of steady flow in carotid bifurcation and carotid siphon geometries as imaged by a standard, flow-compensated, spoiled gradient echo sequence illustrate the major features seen in clinical time of flight MRA studies. The simulations provide insight into a number of artifacts encountered in MRA such as displacement artifacts, signal pile-up, truncation artifacts, and intravoxel phase dispersion.

Evaluation of myocardial perfusion abnormalities with gadolinium-enhanced snapshot MR imaging in humans. Work in progress.

To determine whether myocardial perfusion abnormalities could be detected in patients with coronary artery disease by means of contrast material-enhanced magnetic resonance (MR) images, a snapshot imaging technique was used in six patients with coronary artery disease and four healthy subjects in conjunction with pharmacologic stress (dipyridamole infusion) and bolus injection of gadopentetate dimeglumine. MR images from all patients and healthy subjects were quantitatively analyzed to define spatial changes in signal intensity after administration of dipyridamole and gadopentetate dimeglumine. The resultant findings were compared with findings on thallium-201 scintigrams obtained after administration of dipyridamole and on coronary arteriograms in all patients. Nine myocardial regions supplied by stenosed arteries showed diminished levels of signal intensity after infusion of the contrast agent compared with those of normally perfused regions. These findings were in agreement with those obtained with T1-201 scintigraphy (in eight of nine regions) and arteriography. Thus, contrast-enhanced high-speed MR imaging with use of dipyridamole enabled detection of regional perfusion abnormalities in humans.

Application of a connected-voxel algorithm to MR angiographic data.

A connected-voxel algorithm (CVA) that improves the contrast and conspicuity of blood vessels in maximum-intensity-projection (MIP) magnetic resonance (MR) angiography is described. Images from a variety of anatomic regions in healthy volunteers were calculated with either an MIP procedure alone or with data that had first been processed with the CVA. A low-signal-intensity threshold is first applied to separate groups of voxels associated with different vessels from one another and to eliminate the contribution from low-intensity stationary material. The remaining voxels are grouped by a connectivity criterion into discrete "objects." Vessels are represented by extended objects, and small objects are discarded. The CVA, therefore, reduces the full three-dimensional data set into a small number of discrete objects. It is a powerful technique that can be used to remove signal from vessels overlying the vessel of interest, to separate objects representing arterial flow from those representing venous flow, to eliminate flow artifact from projection images, and to more completely retain signal within the vascular lumen. This technique has been successfully demonstrated with MR angiography in healthy volunteers.