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Food Funct ; 10(1): 33-37, 2019 Jan 22.
Article in English | MEDLINE | ID: mdl-30632580

ABSTRACT

Lactulose, a non-digestible oligosaccharide and functional food, promotes Bifidobacteria growth. Here we show that lactulose, beyond its prebiotic action, may have direct immunomodulatory effects as well. In synergy with CpG-ODN, a bacterial DNA mimetic, lactulose enhances basolateral concentrations of IFN-γ, IL-10, and galectin-9 in the co-culture model of epithelial and immune cells.


Subject(s)
Cell Communication/drug effects , Epithelial Cells/drug effects , Lactulose/pharmacology , Leukocytes, Mononuclear/drug effects , Oligodeoxyribonucleotides/pharmacology , Drug Synergism , Epithelial Cells/cytology , Epithelial Cells/immunology , HT29 Cells , Humans , Interferon-gamma/genetics , Interferon-gamma/immunology , Interleukin-10/genetics , Interleukin-10/immunology , Lactulose/chemistry , Leukocytes, Mononuclear/cytology , Leukocytes, Mononuclear/immunology , Oligodeoxyribonucleotides/chemistry
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