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1.
J Pharm Biomed Anal ; 21(3): 559-67, 1999 Nov.
Article in English | MEDLINE | ID: mdl-10701422

ABSTRACT

For the use in pharmacokinetic studies, a fast and sensitive assay method was developed for the determination of remifentanil in human heparinised whole blood samples of 0.5 ml. The assay method is based on tandem mass spectrometry detection (LC-MS/MS). The limit of quantification is 0.1 ng/ml and linear up to 50 ng/ml. The precision, accuracy, recovery and applicability were found to be adequate for pharmacokinetic studies.


Subject(s)
Heparin/chemistry , Mass Spectrometry/methods , Piperidines/blood , Anesthetics, Intravenous/blood , Calibration , Humans , Remifentanil
2.
J Chromatogr B Biomed Sci Appl ; 710(1-2): 115-20, 1998 Jun 12.
Article in English | MEDLINE | ID: mdl-9686877

ABSTRACT

For use in clinical studies, a fast and sensitive assay method was developed for the determination of nifedipine in human plasma samples. The assay method is based on tandem mass spectrometry detection (HPLC-MS-MS). The effect of flow injection as well as HPLC separation on the results of the nifedipine determination were evaluated. The limit of quantification is 0.5 ng/ml and the accuracy (as determined by spiking recovery) was found to be good.


Subject(s)
Calcium Channel Blockers/blood , Chromatography, High Pressure Liquid/methods , Mass Spectrometry/methods , Nifedipine/blood , Calibration , Evaluation Studies as Topic , Humans , Reproducibility of Results
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