Spatial and temporal effects of interleaved masking in cochlear implants.

Modern cochlear implants utilize interleaved presentation of pulses on different electrodes to avoid physical interference among multiple current fields, yet neural interaction still exists. In the present study, masking was examined with four Nucleus24 users with the banded electrode array in an interleaved masking paradigm, where a probe stimulus was interleaved with a masker stimulus. Spatial and temporal aspects of masking were addressed by fixing the masker at the middle of the electrode array and changing the location of the probe and by testing various stimulation rates: 125, 500, 2,000, and 6,410 Hz. In addition, growth of masking (GOM) was assessed by changing the masker level in six steps. Results indicated that masking patterns were generally much wider, regardless of stimulation rate, than those in acoustic hearing. The amount of masking decreased from the peak at the rate of approximately 0.5 dB/mm even at the highest masker level. The pattern of GOM with the rates higher than 500 Hz was different from that observed in previous masking studies, characterized by markedly shallow growth at low masker levels or overall shallow growth. A facilitating effect of the masker (lowering the threshold) was suspected, except for the 125-Hz condition, due to the fibers that were subliminally excited, but not discharged, by the masker with local perturbations of membrane potentials, and were subsequently discharged easily by a lower level probe when the temporal gap between masker and probe was sufficiently short. These results suggest that both refractory characteristics of neurons and neural summation be considered in interleaved stimulation of pulses at high, but clinically relevant, stimulation rates. Overall, the present masking study might provide a basis for models in psychophysics and speech understanding in current cochlear implant systems utilizing high-rate interleaved stimulation.

Focused intracochlear electric stimulation with phased array channels.

A method is described for producing focused intracochlear electric stimulation using an array of N electrodes. For each electrode site, N weights are computed that define the ratios of positive and negative electrode currents required to produce cancellation of the voltage within scala tympani at all of the N-1 other sites. Multiple sites can be stimulated simultaneously by superposition of their respective current vectors. The method allows N independent stimulus waveforms to be delivered to each of the N electrode sites without spatial overlap. Channel interaction from current spread associated with monopolar stimulation is substantially eliminated. The method operates by inverting the spread functions of individual monopoles as measured with the other electrodes. The method was implemented and validated with data from three human subjects implanted with 22-electrode perimodiolar arrays. Results indicate that (1) focusing is realizable with realistic precision; (2) focusing comes at the cost of increased total stimulation current; (3) uncanceled voltages that arise beyond the ends of the array are weak except when stimulating the two end channels; and (4) close perimodiolar positioning of the electrodes may be important for minimizing stimulation current and sensitivity to measurement errors.

Dual-electrode pitch discrimination with sequential interleaved stimulation by cochlear implant users.

Cochlear implant users may perceive intermediate place-pitches between those elicited by the individual electrodes when two electrodes are stimulated simultaneously or sequentially. This study examined pitch discrimination between adjacent electrodes using sequential dual-electrode stimulation in terms of the sensitivity index, d', which was obtained by adding d's from intermediate dual-electrode stimuli. Loudness was balanced for each tested pair and the intensities were roved. Twelve ears with the Nucleus 24 or Freedom implants demonstrated a wide range of d', from 0.7 to 9.6. "Virtual channels" can be implemented through nonsimultaneous stimulation, with comparable pitch discrimination to that observed with simultaneous stimulation.

Effect of electrode configuration on psychophysical forward masking in cochlear implant listeners.

Bipolar stimulation has been thought to be more beneficial than monopolar stimulation for speech coding in cochlear implants, on the basis of its more restricted current flow. The present study examined whether bipolar stimulation would indeed lead to reduced channel interaction in a behavioral forward masking experiment tested in four Nucleus 24 users. The masker was fixed on one channel and three masker levels that were balanced for loudness between the configurations were chosen. As expected, masking was maximal when the masker and probe channels were spatially close and decreased as they were separated. However, overall masking patterns did not consistently demonstrate sharper tuning with bipolar stimulation than monopolar. This implies that the spatial extent of a bipolar current field is not consistently narrower than that of an equally loud monopolar stimulus; therefore, it should not be assumed that bipolar stimulation leads to reduced channel interaction. Notably, bipolar masking patterns appeared to display more variations across channels, possibly influenced more by anatomical and neural irregularities near electrode contacts than monopolar masking patterns. The present psychophysical results provide a theoretical basis regarding the widespread use (and success) of monopolar configurations by implant users.

Spiral ganglion cell site of excitation I: comparison of scala tympani and intrameatal electrode responses.

To determine the site of excitation on the spiral ganglion cell in response to electrical stimulation similar to that from a cochlear implant, single-fiber responses to electrical stimuli delivered by an electrode positioned in the scala tympani were compared to responses from stimuli delivered by an electrode placed in the internal auditory meatus. The response to intrameatal stimulation provided a control set of data with a known excitation site, the central axon of the spiral ganglion cell. For both intrameatal and scala tympani stimuli, the responses to single-pulse, summation, and refractory stimulus protocols were recorded. The data demonstrated that summation pulses, as opposed to single pulses, are likely to give the most insightful measures for determination of the site of excitation. Single-fiber summation data for both scala tympani and intrameatally stimulated fibers were analyzed with a clustering algorithm. Combining cluster analysis and additional numerical modeling data, it was hypothesized that the scala tympani responses corresponded to central excitation, peripheral excitation adjacent to the cell body, and peripheral excitation at a site distant from the cell body. Fibers stimulated by an intrameatal electrode demonstrated the greatest range of jitter measurements indicating that greater fiber independence may be achieved with intrameatal stimulation.

Genetic algorithms for adaptive psychophysical procedures: recipient-directed design of speech-processor MAPs.

OBJECTIVES: The goal of the research is to evaluate the application of genetic algorithms (GAs) in listener-directed optimization of audio-processing designs. We hypothesize that cochlear-implant recipients can use a GA-guided adaptive psychophysical search procedure to select useful designs from among a large number of speech processor MAPS. DESIGN: An adaptive psychophysical procedure was developed in which a listener's preferred four out of eight speech processor MAPs were updated according to a genetic algorithm. Experiments involving cochlear-implant recipients were conducted to characterize both the convergence behavior of the adaptive procedure as well as properties of the MAPs optimized by the recipient. RESULTS: Results from five cochlear-implant recipients indicate that the adaptive procedure converges to useful speech processor MAPs within twenty iterations. CONCLUSION: The results suggest a means whereby a potentially large number of audio-processing designs can be searched efficiently by a human listener without requiring excessive amounts of feedback or prior knowledge about the listener's preferences. In the case of cochlear-implant recipients, it may be possible to use this procedure as an aid to the clinician in the fitting of a speech processor MAP.