Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
J Biol Chem ; 277(50): 48938-43, 2002 Dec 13.
Article in English | MEDLINE | ID: mdl-12372822

ABSTRACT

Plasma phospholipid transfer protein (PLTP) is thought to be involved in the remodeling of high density lipoproteins (HDL), which are atheroprotective. It is also involved in the metabolism of very low density lipoproteins (VLDL). Hence, PLTP is thought to be an important factor in lipoprotein metabolism and the development of atherosclerosis. We have overexpressed PLTP in mice heterozygous for the low density lipoprotein (LDL) receptor, a model for atherosclerosis. We show that increased PLTP activity results in a dose-dependent decrease in HDL, and a moderate stimulation of VLDL secretion (

Subject(s)
Arteriosclerosis/blood , Carrier Proteins/blood , Membrane Proteins/blood , Phospholipid Transfer Proteins , Animals , Cholesterol, HDL/blood , Cholesterol, VLDL/blood , Cholesterol, VLDL/metabolism , Diet , Male , Mice , Mice, Inbred C57BL , Mice, Transgenic , Risk Factors
SELECTION OF CITATIONS
SEARCH DETAIL
...