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Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.

van der Linden, J W M; Arendrup, M C; Warris, A; Lagrou, K; Pelloux, H; Hauser, P M; Chryssanthou, E; Mellado, E; Kidd, S E; Tortorano, A M; Dannaoui, E; Gaustad, P; Baddley, J W; Uekötter, A; Lass-Flörl, C; Klimko, N; Moore, C B; Denning, D W; Pasqualotto, A C; Kibbler, C; Arikan-Akdagli, S; Andes, D; Meletiadis, J; Naumiuk, L; Nucci, M; Melchers, W J G; Verweij, P E.

Emerg Infect Dis ; 21(6): 1041-4, 2015 Jun.

Article in English | MEDLINE | ID: mdl-25988348

ABSTRACT

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

Subject(s)

Antifungal Agents/pharmacology , Aspergillosis/epidemiology , Aspergillosis/microbiology , Aspergillus fumigatus/drug effects , Azoles/pharmacology , Drug Resistance, Fungal , Population Surveillance , Aspergillus fumigatus/genetics , Humans , Microbial Sensitivity Tests , Mutation , Prevalence , Prospective Studies

ABSTRACT

Subject(s)

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