Tamara Dembo's European years: working with Lewin and Buytendijk.

In this paper early work of the American rehabilitation psychologist Tamara Dembo (1902-1993) is brought to light. She was highly influenced by the concepts of Kurt Lewin's topological psychology, and she used the framework of topological psychology to analyze her investigations on animal behavior carried out with the Dutch zoopsychologist Frederik J. J. Buytendijk. These investigations have so far been ignored and are being described for the first time making use of archival materials.

Bowlby before Bowlby: the sources of an intellectual departure in psychoanalysis and psychology.

John Bowlby's first scientific papers express a viewpoint of the etiology of childhood disorders that gradually developed during his university years and the first years of his professional life. As becomes clear from, among other things, Bowlby's private correspondence, it was the period spent as a student at Cambridge, his work as a teacher at two progressive schools, and his work at a child guidance clinic that allowed him to articulate a view on childhood deviancy that was at variance with the Kleinian variant of psychoanalysis. Bowlby's position as an 'independent' thinker in the British Psycho-Analytical Society can be understood against the background of these intellectual influences.

Antitumoral effects of R 75251 on the growth of transplantable R3327 prostatic adenocarcinoma in rats.

The antitumoral activity of a novel imidazole derivative, R 75,251, has been studied in the androgen-dependent R3327G Dunning prostate adenocarcinoma grafted subcutaneously in syngeneic rats. Dietary application resulting approximately in dose levels of 80, 120, and 160 mg/kg reduced tumor weight by 66, 81, and 79%, respectively. This effect was not significantly different from that measured after castration (-82%). In intact animals, however, serum testosterone levels were almost not affected by R 75,251 treatment while LH levels rose two- to threefold. In castrated rats a tenfold increase in LH was observed. Moreover, prostate and seminal vesicles weights decreased much less after R 75,251 treatment than after castration. In castrated animals, treatment with R 75,251 induced a slight, non-significant reduction in tumor weight (-36%) compared with castration alone. In castrated animals, tumor growth was restored by exogenous administration of testosterone. In such animals R 75,251 also significantly reduced tumor weight by 57%. Similar results were obtained with Dunning R3327G prostate adenocarcinoma grafted beneath the renal capsule in male syngeneic rats receiving twice daily orally by gavage a dose of 80 mg/kg of R 75,251. These data suggest that R 75,251 exerts an antitumoral effect independent of its inhibition of androgen biosynthesis.