Subject(s)
Neoplasms/pathology , Neovascularization, Pathologic , Humans , Neoplasms/therapy , Terminology as TopicABSTRACT
This paper describes an unusual malignant mixed tumor of the bronchus arising in a 71-yr-old male and provides evidence of an epithelial-myoepithelial origin based on the findings on light microscopy and immunohistochemistry. The neoplasm contained elements of recognizable benign tumor resembling salivary gland-type pleomorphic adenoma, adenosquamous carcinoma, and a spindle-cell sarcomatous component. Immunohistochemical stains showed the characteristic relationship between epithelial and myoepithelial cells in the benign component of the neoplasm. In addition, the spindle cells stained for myoepithelial markers (S-100 protein and actin) but were also positive for keratin (AE1/AE3). The relationship of this neoplasm to classical carcinosarcoma and the recently described adenosquamous carcinoma with amyloid-like stroma is discussed.
Subject(s)
Adenoma/pathology , Lung Neoplasms/pathology , Adenocarcinoma/pathology , Adenoma, Pleomorphic/pathology , Aged , Carcinoma, Squamous Cell/pathology , Epithelial Cells , Humans , Male , Myoepithelioma/pathology , Sarcoma/pathologyABSTRACT
The authors report their experience with 17 cases of cystic hygroma diagnosed in utero over a period of 6 years and followed to early infancy. Attempts were made to determine which ultrasonographic features were significant in predicting the outcome of this condition. The intrauterine course of the 6 fetuses with a normal karyotype and the 11 fetuses with Turner's syndrome or another form of aneuploidy was analysed to determine whether the size of the hygroma or the presence of septation or nonimmune hydrops could be used to predict the eventual outcome of the pregnancy. An association between the presence of septation and outcome was not demonstrated, but there was a strong association between septation and aneuploidy. Septate lesions were present in 6 of the 10 fetuses with Turner's syndrome and only 2 of the 6 fetuses with a normal karyotype. In this series the most significant features indicating a favourable outcome were the size of the hygroma (no fetus in which the hygroma had a diameter greater than 6 cm survived) and the change in size from the time of diagnosis until 24 weeks' gestation. Of the three fetuses in which the hygroma did not regress by 24 weeks, two died in utero.
Subject(s)
Fetal Diseases/diagnostic imaging , Lymphangioma/diagnostic imaging , Fetal Diseases/genetics , Fetal Diseases/mortality , Gestational Age , Humans , Karyotyping , Lymphangioma/genetics , Lymphangioma/mortality , Maternal Age , Ploidies , Prognosis , Retrospective Studies , Survival Rate , Turner Syndrome/genetics , UltrasonographyABSTRACT
A case of pneumonia and acute tubular necrosis was caused by an initially unknown species of Legionella. The organism was later identified as Legionella maceachernii by a combination of cultural, biochemical, and serological methods along with a gas-liquid chromatographic profile.
Subject(s)
Legionella/isolation & purification , Legionellosis/microbiology , Pneumonia/microbiology , Canada , Humans , Immunocompromised Host , Legionella/classification , Legionellosis/immunology , Male , Middle AgedABSTRACT
In a clinicopathological study of 70 Brenner tumours in 61 patients seen at Groote Schuur Hospital during the 30-year period 1956-1985, 68 were benign, 1 malignant and 1 proliferating. Fifty-seven were pure tumours and the remainder were mixed with other ovarian neoplasms. The age range of patients was 26-71 years (median 49 years). Most of the Brenner tumours were incidental findings and probably not responsible for the symptoms or signs, which were most commonly a pelvic mass (28 patients) and abnormal vaginal bleeding (15).
Subject(s)
Brenner Tumor/pathology , Ovarian Neoplasms/pathology , Adult , Aged , Female , Humans , Middle AgedABSTRACT
Out of 29 patients with right-sided infective endocarditis 13 had associated congenital heart disease and none was a drug addict. Staphylococcus aureus was the commonest organism isolated. The tricuspid valve was infected twice as commonly as the pulmonary valve. Only 11 out of the 29 patients had valvular infection potentially amenable to surgical therapy at the time of death. Ring abscesses were present in 10 patients.
Subject(s)
Endocarditis, Bacterial/pathology , Adolescent , Adult , Aged , Child , Child, Preschool , Endocarditis, Bacterial/microbiology , Female , Humans , Infant , Male , Middle Aged , Pulmonary Valve/pathologyABSTRACT
A series of 105 patients with organophosphate poisoning admitted to Harari Hospital during the past 4 years is described. Poisoning with organophosphate compounds is being seen more frequently in hospital practice in Rhodesia. Many of the cases are attempted suicides, but frequently there is no positive history of contact with the poison. The majority of patients exhibit the classic clinical features of parasympathetic overactivity, but diagnosis may be obscured by atypical presentation. Rapid diagnosis and utilization of the treatment regimen outlined in this article should reduce the mortality to less than 15%.
