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Thromb Haemost ; 53(1): 118-21, 1985 Feb 18.
Article in English | MEDLINE | ID: mdl-3922075

ABSTRACT

In this longitudinal study we measured beta-TG, PF4, fibrinolytic activity (extrinsic and euglobulin fraction), fibrinogen, FVIII RAg and FVIII Rcof before and after i.v. DDAVP (FPA was only measured before DDAVP) in 20 patients with diabetes mellitus. These parameters were measured on three occasions: phase I: during disregulation, phase II: after three weeks of strict control, phase III: after nine weeks of good control. Twenty-two healthy volunteers served as normal controls. No significant differences related to metabolic control were found for beta-TG, PF4, FPA and fibrinogen. There was no change after i.v. DDAVP administration. Fibrinolytic activity showed a significant increase after i.v. DDAVP. Baseline values and post-DDAVP increase were not significantly different from our normal controls. FVIII RAg and FVIII Rcof were both significantly elevated in diabetes mellitus. Both increased significantly after DDAVP. The FVIII RAg release (delta FVIII RAg) was significantly less in the diabetics. Fibrinolytic activity, FVIII RAg and FVIII Rcof are independent of the degree of metabolic control in patients with diabetes.


Subject(s)
Arginine Vasopressin/pharmacology , Deamino Arginine Vasopressin/pharmacology , Diabetes Mellitus/blood , Adult , Aged , Antigens/analysis , Blood Coagulation/drug effects , Blood Platelets/drug effects , Blood Platelets/metabolism , Diabetic Angiopathies/etiology , Factor VIII/immunology , Female , Fibrinolysis/drug effects , Humans , Male , Middle Aged
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