ABSTRACT
Foi avaliado o tratamento homeopático de um felino com doença renal policística, moléstia hereditária muito comum na espécie felina. Por ser progressiva, o prognóstico depende do estágio de evolução da doença renal crônica, da resposta do felino ao tratamento inicial e do desejo do tutor em dar continuidade ao tratamento. A observação teve duração de 9 (nove) meses e a avaliação dos resultados foi realizada com o emprego de exame clínico e de exames complementares como imagens ultrassonográficas e exames laboratoriais. A terapia foi composta por medicamento homeopático constitucional Phosphorus 30CH e episódico Kresolum 6CH associado à introdução de dieta renal (ração seca adjuvante). O medicamento homeopático não provocou eventos adversos no animal. Os resultados sugerem que um animal com doença policística felina pode ser tratado pela homeopatia.(AU)
The homeopathic treatment of a feline with polycystic kidney disease was evaluated, a common hereditary disease in the feline species. Because it is progressive, the prognosis depends on the stage of evolution of the chronic kidney disease, the feline response to the initial treatment and the guardian's desire to continue the treatment. The observation lasted 9 (nine) months and the evaluation of the results was performed through clinical examination and complementary tests such as ultrasound images and laboratory tests. The therapy was composed of constitutional Phosphorus 30CH and episodic Kresolum 6CH homeopathic medication associated with the introduction of diet kidney diet (adjunct dry feed). The homeopathic medicine did not cause adverse events in the animal. The results suggest that an animal with feline polycystic disease can be treated by homeopathy.(AU)
Subject(s)
Animals , Cats , Cat Diseases/diagnosis , Homeopathy/veterinary , Polycystic Kidney Diseases/veterinaryABSTRACT
Under LPS-stimulus, platelets can activate macrophagesby a cell-to-cell contact or through cytokine degranulation. Rebound effects of anti-thrombotic agents, such as prostanoids and COX inhibitors can lead to thrombosis, infarct, and stroke. Aspirin has been prescribed for decades due to its powerful antiplatelet action, but it is also related to paradoxical effects such as withdrawal syndrome peaks, resistance, and thrombogenesis. Ultra-diluted aspirin can also produce the same effect in one hour, regardless of Cox-2, by still unknown pathways. Antithrombotic effects of aspirin are also reversed by its high dilutions.Aims: This study aims to characterize the effects of aspirin 15cH on macrophages challenged with LPS, a Cox-2 activator.Methodology: RAW 264.7 macrophages were sown in 24 wells plates using R10medium, boosted with 1µg/ml LPS,and treated with aspirin 15 cH and controls. The activity was evaluated after 24 hours. Supernatants were evaluated for cytokines, nitric oxide, and dielectric oscillations, through solvatochromic dyes (Cartwright's method).Results and discussion: macrophage spreading was increased by aspirin 15 cH, anLPS-like effect. Paradoxically, a significant reduction of this effect was noted when both, LPS and aspirin 15 cH, were added. Succussed water reversed the effect of LPS, leading to TNF (p<0.05) production close to baseline levels. Also, the single treatment with succussed water inhibited IL-10 production (p<0.05), but aspirin 200 µg/mL (positive control) highly increased it (p<0.0001), showing the validity of the model. Nitric oxide production was strengthened by LPS presence (p<0.0001), as expected, but partially downregulated after treatment with aspirin 200 µg/mL, water and succussed water. A pilot study with solvatochromic dyes showed no significant difference among treatments.Conclusion: The main data suggest that aspirin 15 cH increases macrophage activity but presents a paradoxal effect when mixed with LPS. On the other hand, succussed water itself has modulatory effects on macrophages.
Subject(s)
Preparation Scales , Aspirin/therapeutic use , Macrophage ActivationABSTRACT
As doenças hepatobiliares possuem um importante papel na rotina clínica médico veterinária e sendo o fígado um órgão vital, é imprescindível que seus males sejam identificados rapidamente. Estima-se que o fígado realize em torno de 1.500 funções bioquímicas essenciais à vida. A associação ciência e psicossomática nunca esteve tão em evidência e recebe cada vez mais simpatizantes insatisfeitos com a alopatia clássica. Portanto este trabalho de monografia sugere a homeopatia como terapia das doenças hepatobiliares de cães e gatos, mencionando os medicamentos homeopáticos que podem ser utilizados para tal, evidenciando não apenas os sintomas físicos que estes abrangem, mas também os sintomas mentais. (AU)
Hepatobiliary diseases play an important role in clinical routine veterinary doctor and the liver being a vital organ, it is essential that their ailments are identified quickly. It is estimated that the liver carry around 1,500 biochemical functions essential for life. Science and psychosomatic association has never been such in evidence and receives more and more supporters dissatisfied with the classic allopath. Therefore this thesis work aims to suggest homeopathy as therapy of hepatobiliary diseases of dogs and cats, citing homeopathic medicines that can be used for this, showing not only the physical symptoms they cover, but also the mental symptoms. (AU)
